Gastric bypass–induced weight loss alters obesity-associated patterns of plasma pentraxin-3 and systemic inflammatory markers

Barazzoni, Rocco; Palmisano, Silvia; Cappellari, Gianluca Gortan; Giuricin, Michela; Moretti, Elisa; Vinci, Pierandrea; Semolic, A.; Guarnieri, Gianfranco; Zanetti, Michela; Manzini, Nicoló de

doi:10.1016/j.soard.2015.04.013

Cited by 19 publications

(16 citation statements)

References 36 publications

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“…Furthermore, patients presented with a decreased proinflammatory status as suggested by the dramatic drop in hs-CRP and a similar increase in the anti-inflammatory cytokine IL-10. The results obtained in our cohort are in line with previous experiences in RYGB surgery patients [35].…”

Section: Discussionsupporting

confidence: 92%

Roux-en-Y-Bariatric Surgery Reduces Markers of Metabolic Syndrome in Morbidly Obese Patients

et al. 2019

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Background Obesity is closely linked to increased markers of metabolic syndrome and development of diabetes. Roux-en-Y bariatric surgery reduces hyperinsulinemia and improves insulin sensitivity and hence benefits morbidly obese patients. Aim To determine changes in markers of metabolic syndrome, pancreatic function, and hepatic insulin sensitivity in patients before and 1 year after undergoing Roux-en-Y gastric bypass surgery. Methods We enrolled 43 consecutive patients in a single center. Markers for metabolic syndrome included proinsulin, insulin, Cpeptide, liver enzymes, and serum levels of selected microRNAs hsa-miR-122, hsa-miR-130, hsa-miR-132, and hsa-miR-375. Results After surgery, all patients showed a significant 37% drop of body mass index (p < 0.001). Furthermore, proinsulin (59% reduction, p < 0.001), insulin (76% reduction, p < 0.001), and C-peptide (56% reduction, p < 0.001) were all reduced 1 year after surgery. Using the hepatic insulin clearance score, we determined a significant increase in hepatic insulin clearance after surgery (76% increase, p < 0.001). Especially diabetic patients showed a marked 2.1-fold increase after surgery. Hepatic enzymes ALT (35% reduction, p = 0.002) and γGT (48% reduction, p < 0.001) were significantly reduced in all patients with similar improvement in diabetic and non-diabetic patients. miRNAs hsa-miR-122, hsa-miR-130, and hsa-miR-132 were all significantly reduced whereas hsa-miR-375 was increased after gastric bypass surgery (p < 0.001 for all miRNAs). Conclusion Both liver and pancreatic stress parameters were reduced significantly 1 year after Roux-en-Y gastric bypass surgery suggesting an overall amelioration of the metabolic syndrome in all patients regardless of previous health status.

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Section: Discussionsupporting

confidence: 92%

Roux-en-Y-Bariatric Surgery Reduces Markers of Metabolic Syndrome in Morbidly Obese Patients

et al. 2019

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“…Although pentraxin-3 has been reported to have both pro- and anti-inflammatory effects [33], our finding suggests that it had beneficial effects on insulin action in our subjects. Cross-sectional studies have reported low pentraxin-3 concentrations with increasing adiposity [12,34,35] and insulin resistance [35] and in agreement with our findings, other studies showed that weight loss increases pentraxin-3 concentrations [12,36]. However, to our knowledge, ours is the only study to evaluate the association between pentraxin-3 and insulin sensitivity in response to weight loss.…”

Section: Discussionsupporting

confidence: 92%

Circulating cytokines as determinants of weight loss-induced improvements in insulin sensitivity

et al. 2016

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Purpose Dietary calorie restriction (CR) and exercise (EX) promote weight loss and may have additive effects for improving insulin sensitivity, independent of weight loss. It is not known if these effects are attributable to changes in circulating cytokines. We evaluated the hypothesis that modest, matched weight loss induced by CR and EX have additive effects on circulating cytokines and these changes correlate with improvements in insulin sensitivity. Methods Overweight and sedentary women and men (n=52, 45–65y) were randomized to undergo 7% weight loss by using 3–6 months of CR, EX, or a combination of both (CREX). Concentrations of cytokines and hormones were measured in fasting and oral glucose tolerance test (OGTT) blood samples. Insulin sensitivity was estimated based on OGTT glucose and insulin. Results With all groups combined fasting leptin (p<0.0001) and HMW adiponectin (p=0.04) decreased and pentraxin-3 increased (p<0.0001), in a manner that correlated with improvements in insulin sensitivity (all p≤0.0002). These changes, combined with decreases in glucose-dependent insulinotropic polypeptide from the OGTT, explained 63% of the variance (p<0.0001) in insulin sensitivity improvements. EX and CR had additive effects on leptin, with a similar trend for HMW adiponectin. MCP-1 and CRP concentrations did not change. CR and EX had opposite effects on soluble TNF receptor-1. Conclusions Modest weight loss in overweight adults decreases serum leptin and HMW adiponectin, and increases pentraxin-3 concentrations in a manner that correlates with increased insulin sensitivity. Exercise has additive effects to those induced by CR for reductions in leptin and possibly adiponectin. These changes may contribute to the additive effects of CR and exercise for improving insulin sensitivity.

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“…The current study revealed a higher serum PTX3 level in obese cases than controls, which is supported by a recent study by Barazzoni et al [48]. The PTX3 level was even higher in cases with fatty liver proven by ultrasound, especially those with elevated liver enzyme levels.…”

Section: Discussionsupporting

confidence: 91%

Serum Pentraxin 3 Fragment as a Noninvasive Marker of Nonalcoholic Fatty Liver Disease in Obese Children and Adolescents

2016

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Background/Aims: It was suggested that serum pentraxin 3 (PTX3) levels could differentiate obese children with nonalcoholic steatohepatitis (NASH) from those with simple steatosis. Thus, we aimed to evaluate the clinical utility of serum PTX3 fragment levels in the diagnosis of NASH and the assessment of its severity in obese children with suspected nonalcoholic fatty liver disease (NAFLD). Methods: Fifty obese children were compared to 25 matched controls. All were subjected to history taking, anthropometric measurements, and abdominal ultrasonography, as well as laboratory assessments of liver functions, fasting lipid profile, fasting blood glucose, fasting insulin, homeostasis model assessment (HOMA) index, fasting glucose/insulin ratio, and serum PTX3. Results: PTX3 was higher in obese cases than controls (p = 0.0001). Eighty percent of the cases had NAFLD with progressive increases in PTX3 levels as the severity of fatty liver increased (p = 0.0001). Moreover, PTX3 was higher in cases with elevated liver enzymes (3.205 ± 0.77 U/l) than those with normal liver enzymes (2.77 + 0.69 U/l, p < 0.0001). A cutoff value of 3.03 U/l differentiated fatty liver from NASH with a sensitivity of 89% and a specificity of 86%. Conclusion: Noninvasive monitoring of serum PTX3 fragment levels in obese patients with suspected NAFLD may be used as a reliable tool for differentiating NASH from simple fatty liver.

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Gastric bypass–induced weight loss alters obesity-associated patterns of plasma pentraxin-3 and systemic inflammatory markers

Cited by 19 publications

References 36 publications

Roux-en-Y-Bariatric Surgery Reduces Markers of Metabolic Syndrome in Morbidly Obese Patients

Roux-en-Y-Bariatric Surgery Reduces Markers of Metabolic Syndrome in Morbidly Obese Patients

Circulating cytokines as determinants of weight loss-induced improvements in insulin sensitivity

Serum Pentraxin 3 Fragment as a Noninvasive Marker of Nonalcoholic Fatty Liver Disease in Obese Children and Adolescents

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