Gastric calcifying fibrous tumor: A case of suspected immunoglobulin G4-related gastric disease

Zhang, Hejun; Jin, Zhu; Ding, Shigang

doi:10.4103/1319-3767.170950

Cited by 30 publications

(15 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Kuo et al described splenic angiomatoid nodular transformation associated with disseminated abdominal, gastric, and small intestinal calcifying fibrous tumors, which all demonstrated IgG4-positive plasma cells [14]. Subsequently reported gastric calcifying fibrous pseudotumors have been reported to harbor IgG4-positive plasma cells in some but not all cases [10,15]. Our IHC studies did not demonstrate substantial IgG4+ cell infiltration.…”

Section: Discussionmentioning

confidence: 40%

Calcifying Fibrous Pseudotumor of the Pancreas in a Patient With Metastatic Mammary Lobular Carcinoma and Gastric Gastrointestinal Stromal Tumor: A Previously Undescribed Benign Mimic of Metastatic Disease

Jabbour¹,

Panarelli²,

Muscarella³

et al. 2020

Cureus

View full text Add to dashboard Cite

Calcifying fibrous pseudotumor, a benign spindle cell tumor, has not been reported previously in the pancreas. Herein, we report a case of pancreatic calcifying fibrous pseudotumor in a 74year-old female with a history of metastatic breast carcinoma and gastric gastrointestinal stromal tumor (GIST), both confounding the diagnosis and rendering it more challenging. Microscopic examination showed a well-demarcated, paucicellular, densely fibrotic tumor with widespread dystrophic calcifications and sparse, cytologically bland polygonal and spindle cells. Histologic and immunohistochemical work-up helped to exclude relevant differential diagnoses, including metastatic carcinoma, solitary fibrous tumor, inflammatory myofibroblastic tumor, and GIST.

show abstract

Section: Discussionmentioning

confidence: 40%

Calcifying Fibrous Pseudotumor of the Pancreas in a Patient With Metastatic Mammary Lobular Carcinoma and Gastric Gastrointestinal Stromal Tumor: A Previously Undescribed Benign Mimic of Metastatic Disease

Jabbour¹,

Panarelli²,

Muscarella³

et al. 2020

Cureus

View full text Add to dashboard Cite

show abstract

“…No randomized controlled trial was included in the review. Finally, 30 full-text articles [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 ] were included ( Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

“…In 2013, the first case of gastric CFT was treated with ESD [ 20 ]. Two patients were successfully treated with endoscopic full-thickness resection (EFR) in 2014 [ 22 ]. EFR may also be another choice for a patient with SMT arising from the muscle layer.…”

Section: Discussionmentioning

confidence: 99%

Gastric Calcifying Fibrous Tumor: An Easy Misdiagnosis as Gastrointestinal Stromal Tumor–A Systemic Review

et al. 2020

View full text Add to dashboard Cite

Background and Objectives: Calcifying fibrous tumor (CFT) in the stomach is extremely rare and is easily misdiagnosed as a gastrointestinal stromal tumor (GIST). This study aims to determine the best method to differentiate between gastric CFT and GIST after a systemic review and meta-analysis. Materials and Methods: A systematic search of articles using electronic databases (MEDLINE, EMBASE, and LILACS) was conducted and resulted in 162 articles with 272 CFT cases published from January 1988 to September 2019. Results: Of these cases, 272 patients, 60 patients with gastric CFT (32 men and 28 women, mean age 49.2 years) were analyzed. The mean tumor size was 2.4 cm in patients with gastric CFT. Both endoscopic ultrasound (EUS) and computed tomography (CT) findings revealed well-defined (100% vs. 77.8%), heterogeneous (100% vs. 77.8%), iso-hypoechoic (71.4% vs. 33.3%), and calcified (85.7% vs. 77.8%) lesions, respectively. The majority of patients (53.3%) were symptomatic, with the most common symptom being abdominal discomfort (55.6%). None of the patients with gastric CFT showed recurrence after treatment, and most patients received nonendoscopic treatment (56%, n = 28/50). Both age and tumor size were statistically significant in patients with gastric CFT than GIST (49.2 vs. 65.0 years and 2.4 vs. 6.0 cm; both p < 0.001). The ratio of children among patients with CFT (5%) and GIST (0.05%) was also significantly different (p = 0.037). The calcification rates of gastric CFT had significantly higher calcification rates than GIST on images of EUS and CT (85.7% vs. 3.6% and 77.8% vs. 3.6%; both p < 0.001). Conclusions: Compared with patients with GIST, patients with gastric CFT were younger, had smaller tumor size, and were symptomatic. Furthermore, gastric CFT was well-defined, heterogeneous in the third layer, and had high calcification rates on the images.

show abstract

“…Some researchers have reported CFT was associated with immunoglobulin G4-related disease (IgG4-related disease) and suggest corticosteroid treatment, but radical tumor removal by surgery is the major treatment method, because postoperative histopathology and immunohistochemistry can obtain a definitive diagnosis. [16,17]…”

Section: Discussionmentioning

confidence: 99%

Ultrasonographic imaging of calcifying fibrous tumor of cervical esophagus

Lü

Wu³

et al. 2019

Medicine

View full text Add to dashboard Cite

Rationale: Calcifying fibrous tumor (CFT) is a rare benign mesenchymal tumor characterized by cytologically benign fibroblasts that produce abundant collagen with scattered lymphocytes, plasma cells, and psammomatous or dystrophic calcifications. Patient concerns: A 37 years old women was initially diagnosed thyroid nodule in local hospital. She was referred to receive microwave ablation of the nodule in our hospital. The patient was in good health with occasional foreign body sensation in the neck. Routine laboratory examination was normal. Diagnosis: The lesion was suspected benign and originating from the esophagus rather than the thyroid gland by conventional ultrasound and contrast-enhanced ultrasound in our hospital and was finally proved to be CFT by pathology. Interventions: The lesion was surgically removed. Outcomes: The patient recovered well and was followed up for 2 years without recurrence. Lessons: Although imaging diagnosis of CFT is difficult, the findings of clear border, coarse calcification on conventional ultrasound and peripheral hypoenhancement without central enhancement on contrast-enhanced ultrasound (CEUS), together with real-time evaluation of the relationship between the tumor and esophagus help to distinguish CFT of cervical esophagus from other lesions in the neck.

show abstract

Gastric calcifying fibrous tumor: A case of suspected immunoglobulin G4-related gastric disease

Cited by 30 publications

References 10 publications

Calcifying Fibrous Pseudotumor of the Pancreas in a Patient With Metastatic Mammary Lobular Carcinoma and Gastric Gastrointestinal Stromal Tumor: A Previously Undescribed Benign Mimic of Metastatic Disease

Calcifying Fibrous Pseudotumor of the Pancreas in a Patient With Metastatic Mammary Lobular Carcinoma and Gastric Gastrointestinal Stromal Tumor: A Previously Undescribed Benign Mimic of Metastatic Disease

Gastric Calcifying Fibrous Tumor: An Easy Misdiagnosis as Gastrointestinal Stromal Tumor–A Systemic Review

Ultrasonographic imaging of calcifying fibrous tumor of cervical esophagus

Contact Info

Product

Resources

About