Gastric cancer—Epidemiology, modifiable and non-modifiable risk factors, challenges and opportunities: An updated review

Mamun, Tajul Islam; Younus, Sabrina; Rahman, Md. Hashibur

doi:10.1016/j.ctarc.2024.100845

Cancer Treatment and Research Communications

2024

DOI: 10.1016/j.ctarc.2024.100845

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Gastric cancer—Epidemiology, modifiable and non-modifiable risk factors, challenges and opportunities: An updated review

Tajul Islam Mamun,

Sabrina Younus,

Md. Hashibur Rahman

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2024

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Cited by 2 publications

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Minimally Invasive Versus Open Distal Gastrectomy for Locally Advanced Gastric Cancer: Trial Sequential Analysis of Randomized Trials

Aiolfi,

Calì,

Cammarata

et al. 2024

Cancers

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Background. Minimally invasive distal gastrectomy (MIDG) has been shown to be associated with improved short-term outcomes compared to open distal gastrectomy (ODG) in patients with locally advanced gastric cancer (LAGC). The impact of MIDG on long-term patient survival remains debated. Aim was to compare the MIDG vs. ODG effect on long-term survival. Methods. Systematic review and trial sequential analysis (TSA) of randomized controlled trials (RCTs). Web of Science, Scopus, MEDLINE, the Cochrane Central Library, and ClinicalTrials.gov were queried. Hazard ratio (HR) and 95% confidence intervals (CI) were used as pooled effect size measures. Five-year overall (OS) and disease-free survival (DFS) were primary outcomes. Results. Five RCTs were included (2835 patients). Overall, 1421 (50.1%) patients underwent MIDG and 1414 (49.9%) ODG. The ages ranged from 48 to 70 years and 63.4% were males. The pooled 5-year OS (HR = 0.86; 95% CI 0.70–1.04; I2 = 0.0%) and 5-year DFS (HR = 1.03; 95% CI 0.87–1.23; I2 = 0.0%) were similar for MIDG vs. ODG. The TSA shows a cumulative z-curve without crossing the monitoring boundaries line (Z = 1.96), thus suggesting not conclusive 5-year OS and DFS results because the total information size was not sufficient. Conclusions. MIDG and ODG seem to have equivalent 5-year OS and DFS in patients with LAGC. However, the cumulative evidence derived from the TSA showed that the actual information size is not sufficient to provide conclusive data.

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Minimally Invasive Versus Open Distal Gastrectomy for Locally Advanced Gastric Cancer: Trial Sequential Analysis of Randomized Trials

Aiolfi,

Calì,

Cammarata

et al. 2024

Cancers

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The role of andrographolide as a potential anticancer agent against gastric cancer cell lines: a systematic review

Anis Amiera,

Tuan Kub,

Harun

et al. 2024

PeerJ

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Objective To critically analyse literature on the anticancer properties of andrographolide in in vitro studies on gastric cancer cells. Method This study systematically reviewed articles from 2013 to 2024 across five prominent databases; PubMed, Google Scholar, Web of Science, Scopus, and Science Direct, EMBASE, Cochrane library and DOAJ. The study eligibility criteria include original studies assessing using gastric cancer cell lines and articles utilizing extracted andrographolide from Andrographis paniculata or standard andrographolide source treatment. The following exclusion criteria were articles written in a different language, review articles, book chapters, conference articles, scientific reports. Duplicated articles were removed using Mendeley software. Result Out of 93 articles, six were relevant, primarily focusing on in vitro analyses with gastric adenocarcinoma cell lines. Conclusion These studies indicate that andrographolide can hinder the cell cycle, suppress cell proliferation, alleviate oxidative stress, and induce apoptosis by prompting gastric cancer cells to undergo self-destruction, which is a crucial mechanism for controlling and eliminating cancerous growths.

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Gastric cancer—Epidemiology, modifiable and non-modifiable risk factors, challenges and opportunities: An updated review

Cited by 2 publications

References 304 publications

Minimally Invasive Versus Open Distal Gastrectomy for Locally Advanced Gastric Cancer: Trial Sequential Analysis of Randomized Trials

Minimally Invasive Versus Open Distal Gastrectomy for Locally Advanced Gastric Cancer: Trial Sequential Analysis of Randomized Trials

The role of andrographolide as a potential anticancer agent against gastric cancer cell lines: a systematic review

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