Gastric cancer in Norfolk

Caygill, C. P. J.; Day, Daphne; Hill, Michael J.

doi:10.1038/bjc.1986.21

Cited by 7 publications

(1 citation statement)

References 8 publications

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“…Similar results have been published from other countries as well (5,6). (11)(12)(13)(14)(15), all of whom have found that the incidence of IGCA, in contrast to that of DGCA, is high among residents in or migrants from geographic areas with a high GCA incidence, whereas it is low among those from areas with a low GCA incidence. These observations might indicate that the relative proportion of IGCA among all cases of GCX and the total incidence of GCA are positively related; that is, IGCA is commoner in high-incidence (high-risk) populations than DGCA, and vice versa (4, 10).…”

Section: P Sipponen Et A1mentioning

confidence: 88%

Decreased Incidences of Intestinal and Diffuse Types of Gastric Carcinoma in Finland during a 20-Year Period

Sipponen

Järvi

Kekki

et al. 1987

Scandinavian Journal of Gastroenterology

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The incidence of gastric carcinoma (GCA) has decreased throughout the world. This decrease is attributed to a decline in incidence of the intestinal type of GCA (IGCA), whereas the diffuse (DGCA) type of GCA is considered to be endemic in nature and more stable in incidence. In the present study we have estimated how much the incidences of IGCA and DGCA have decreased in percentage in Finland from 1952-61 to 1972-81. Our calculations are based on the Finnish Cancer Registry data of new GCA cases, on population statistics in Finland, and on the percentage distribution of GCA subtypes in three consecutive samples of GCA patients collected in the time periods 1952-61 (reference series) and 1972-81 (two separate samples: series A and B). The samples totaled 1837 GCA cases. We calculated that the incidence of IGCA had decreased from 1952-61 to 1972-81 by 62-71% (reference series versus series A - reference series versus series B) among men and by 69-70% among women. Correspondingly, the incidence of DGCA was calculated to have decreased by 30-39% among men and 37-42% among women. We conclude that not only has the incidence of IGCA decreased in percentage approximately twice as much as the incidence of DGCA but DGCA has also distinctly decreased in incidence in Finland from 1952-61 to 1972-81.

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Section: P Sipponen Et A1mentioning

confidence: 88%

Decreased Incidences of Intestinal and Diffuse Types of Gastric Carcinoma in Finland during a 20-Year Period

Sipponen

Järvi

Kekki

et al. 1987

Scandinavian Journal of Gastroenterology

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Gastric cancer in a high-risk area in italy: Histopathologic patterns according to Lauren's classification

Amorosi

Bianchi

Buiatti

et al. 1988

Cancer

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Two thousand five hundred forty cases (1628 males and 912 females) of primary gastric cancer (GC) histologically diagnosed in gastroscopic biopsy or resected specimens, occurring from 1973 to 1982 in a high risk area in Italy (Florence), were reviewed. According to Lauren's criteria, 1587 (62.5%) were classified as intestinal type, 624 (24.6%) as diffuse type and 329 (12.9%) as mixed unclassified. The intestinal type is more frequent in males and increases in both sexes with advancing age; conversely for the diffuse type. In the two 5-year periods (1973-1977 and 1978-1982) the intestinal type shows a reduction over time more evident in females than in males, in contrast to the increasing trend for the diffuse type. In males, the distribution of Lauren's histologic types is stable over time for resected specimens, whereas there is a significant reduction of intestinal type for biopsy specimens. In females, both for resected and biopsy specimens there is a reduction of the intestinal type and an increase of the diffuse type from the first to the second period. For a subgroup of 297 subjects two different specimens were available (gastroscopic biopsy and surgical); sensitivity and positive predictive value, for biopsy specimen as compared with the resected one, in the diagnosis for Lauren's histologic types were calculated. An excess of diagnoses in the mixed/unclassified category for biopsy material was evident (positive predictive value = 44.3%). However, for the two main histologic types, the biopsy appears a quite reliable indicator of the final diagnosis on surgical material (intestinal: ppv = 88.6%; Diffuse: ppv = 87.0%). The study supports the hypothesis that the reduction in GC mortality in the Province of Florence in recent years may be associated with a moderate reduction in the frequency of the intestinal type.

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Epidemiology of intestinal and diffuse types of gastric carcinoma a time-trend study in finland with comparison between studies from high- and low-risk areas

Laurén

Nevalainen

1993

Cancer

152

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The incidence of gastric cancer has declined markedly in Finland during the last 4 decades. To document the changes caused by that in the ratio of the intestinal type (IT) to the diffuse type (DT) of gastric carcinoma we compared the 367 cases diagnosed from southwestern Finland at the Department of Pathology, Turku University, from 1950–1959 and 1076 cases from 1980–1989. IT virtually disappeared in the male and female populations younger than 50 years, and in patients younger than 60 years, DT became more common than IT (P < 0.001). The transitional age, the time at which IT exceeds DT in frequency, shifted by 20 years to older age groups. In patients older than 60 years, IT remained the dominant type, but the ratio of IT to DT (IT:DT) decreased in men from 3.8 to 2.1 (P < 0.05) and in women from 4.4 to 2.1 (P < 0.001). No decrease in the frequency of DT could be demonstrated in the material studied. The disappearance of the male‐dominant IT in the younger male population changed the male‐to‐female ratio of patients reported to the Finnish Cancer Registry. When the ratio IT:DT in Finland was compared with the ratios reported by the authors in data from other continents and by other investigators, regional variations in basal level of IT:DT emerged. This phenomenon seems to be based on the differing genetic susceptibility to DT of various races. The decrease of IT, seen in reports from regions with declining incidence of gastric carcinoma, seems to be connected to a diminished rate of severe chronic gastritis.

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Gastric cancer in Norfolk

Cited by 7 publications

References 8 publications

Decreased Incidences of Intestinal and Diffuse Types of Gastric Carcinoma in Finland during a 20-Year Period

Decreased Incidences of Intestinal and Diffuse Types of Gastric Carcinoma in Finland during a 20-Year Period

Gastric cancer in a high-risk area in italy: Histopathologic patterns according to Lauren's classification

Epidemiology of intestinal and diffuse types of gastric carcinoma a time-trend study in finland with comparison between studies from high- and low-risk areas

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