Gastric cancer in Singapore

Look, M.; Gao, Fei; Low, C. K.; Nambiar, Rajalakshmi

doi:10.1007/s10120-001-8013-9

Cited by 9 publications

(12 citation statements)

References 2 publications

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“…Importantly, there was a steady decline in the ASR, consistent to what have been reported elsewhere (Look et al, 2001;IARC, Globocan 2012;Atrkar-Roushan et al, 2013). H. pylori is a very important factor in the pathogenesis of gastric cancer and certain bacterial virulent characteristics virulent characteristics are very important (Cover et al, 2013;Sepulveda., 2013).…”

Section: Discussionsupporting

confidence: 67%

Gastric Cancer in Brunei Darussalam: Epidemiological Trend Over a 27 Year Period (1986-2012)

Chong

Telisinghe²,

Abdullah³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Gastric cancer is the second most common gastrointestinal cancer and is more common in the East, compared to the West. This study assesses the trend of gastric cancers in Brunei Darussalam, a developing nation with a predominantly Malay population. Materials and Methods: The cancer registry from 1986 to 2012 maintained by the Department of Pathology, the only State Laboratory at the RIPAS Hospital, Ministry of Health, was reviewed and data extracted for analyses. The age standardised rate (ASR) and age specific incidence rate were calculated based on the projected population. Cancers diagnosed below 45 years were categorised as young gastric cancer. Results: Over the study period, there were a total of 551 cases of gastric cancer diagnosed. The most common type was adenocarcinoma (87.9%), followed by lymphoma (6.1%) and gastrointestinal stromal tumour (2.8%). The overall mean age at diagnosis was 61.9 years old (range 15 to 98) with an increasing trend observed, but this was not significant (ANOVA). There were differences in the mean age at diagnosis for the different races (p=0.003 for trend), but not the gender (p=0.105). Young gastric cancer accounted for 14.9%, being more common in women, and in Expatriate and Malay populations compared to the Chinese. There was a decrease in the ASR, from 17.3/100,000 in 1986-1990 to 12.5/100,000 in 2006-2010. Chinese had a higher overall ASR (20.2/100,000) compared to the Malays (11.8/100,000). The age specific rates were comparable between men and women until the age group 55-59 years when the rates started to diverge, becoming higher in men. Chinese men had higher rates then Malay men whereas, the rates were higher or comparable between the women until the age group >70 when the rate for Chinese women overtook their Malay counterpart. Conclusions: Our study showed that there is a declining trend in the incidence of gastric cancer and higher rates were observed in men and Chinese.

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Section: Discussionsupporting

confidence: 67%

Gastric Cancer in Brunei Darussalam: Epidemiological Trend Over a 27 Year Period (1986-2012)

Chong

Telisinghe²,

Abdullah³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…The frequency of repeated EPIYA‐C motifs reported in the present study (13 of 43, 30.2%) is not significantly different from that reported in comparable studies from Greece (12 of 58 adults, 20.7%) and Italy (12 of 42, 28.6%) [27,48]. When comparing the GC rates (ASR) of these populations, Italy has a slightly higher rate (9.7 and 18.8 for females and males, respectively), than Greece (5.9 and 12.0 for females and males, respectively) or Indians resident in Malaysia and Singapore (6.3 and 7.9 for females, and 12.9 and 8.4 for males, respectively) [33,34,56]. Any apparent differences may be explained by the contribution of host genetics and environmental factors, which are well known to vary between populations.…”

Section: Discussionmentioning

confidence: 99%

“…Within Malaysia and Singapore a considerable disparity exists between the prevalence of H. pylori and the development of GC within the three primary ethnic groups [28]. Ethnic Chinese residing in these two countries have been reported to have an H. pylori seropositivity of between 26.7–58.6% in Malaysia [29–31] and 45.8–46.8% in Singapore [32], and have a relatively high age standardized risk (ASR) for GC (males: 11.9 and 25.7, and females: 8.7 and 12.6, respectively) [33,34]. Conversely, while the H. pylori seropositivity in Indians resident in Malaysia and Singapore (49.4–52.3% and 45.1–51.1%, respectively) is generally higher than ethnic Chinese [29–32], the rate of GC is lower (ASR males: 12.9 and 8.4, and females: 6.3 and 7.9, respectively) [33,34].…”

mentioning

confidence: 99%

Distinct cagA EPIYA Motifs are Associated with Ethnic Diversity in Malaysia and Singapore

et al. 2009

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Although, H. pylori strains with distinct cagA-types are circulating within the primary ethnic groups resident in Malaysia and Singapore, these genotypes appear unassociated with the development of GC in the ethnic Chinese population. The phenomenon of distinct strains circulating within different ethnic groups, in combination with host and certain environmental factors, may help to explain the rates of GC development in Malaysia.

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“…It has been estimated that there are 876 000 new cases diagnosed and 649 000 deaths reported per annum worldwide (Roberts-Thompson and Butler, 2005). Countries of high incidence include Singapore, China, Japan and Russia (Look et al 2001). The overall decrease in the incidence of gastric cancer has been attributed to domestic refrigeration, a decrease in the intake of salted, smoked and pickled foods and the greater availability and consumption of fresh fruit and vegetables.…”

Section: Introductionmentioning

confidence: 99%

“…There are other environmental factors, apart from diet, that increase the risk of gastric cancer in susceptible individuals including tobacco smoking (Nouraie et al 2005), alcohol consumption (Leung et al 2005) and Helicobacter pylori infection (Normark et al 2003). A two to three fold increase in the risk of gastric cancer has been linked to H. pylori infection in some but not all populations (Look et al 2001). There is epidemiological evidence of genetic risk factors associated with gastric cancer including higher than predicted concordance rates in identical and non-identical twins and first degree relatives of patients with gastric cancer having a two to three fold increased risk of developing the disease (El-Omar et al 2000).…”

Section: Introductionmentioning

confidence: 99%

Gastric Cancer (Biomarkers) Knowledgebase (GCBKB): A Curated and Fully Integrated Knowledgebase of Putative Biomarkers Related to Gastric Cancer

et al. 2006

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The Gastric Cancer (Biomarkers) Knowledgebase (GCBKB) (http://biomarkers.bii.a-star.edu.sg/background/gastricCancerBiomarkersKb.php) is a curated and fully integrated knowledgebase that provides data relating to putative biomarkers that may be used in the diagnosis and prognosis of gastric cancer. It is freely available to all users. The data contained in the knowledgebase was derived from a large literature source and the putative biomarkers therein have been annotated with data from the public domain. The knowledgebase is maintained by a curation team who update the data from a defined source. As well as mining data from the literature, the knowledgebase will also be populated with unpublished experimental data from investigators working in the gastric cancer biomarker discovery field. Users can perform searches to identify potential markers defined by experiment type, tissue type and disease state. Search results may be saved, manipulated and retrieved at a later date. As far as the authors are aware this is the first open access database dedicated to the discovery and investigation of gastric cancer biomarkers.

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Gastric cancer in Singapore

Cited by 9 publications

References 2 publications

Gastric Cancer in Brunei Darussalam: Epidemiological Trend Over a 27 Year Period (1986-2012)

Gastric Cancer in Brunei Darussalam: Epidemiological Trend Over a 27 Year Period (1986-2012)

Distinct cagA EPIYA Motifs are Associated with Ethnic Diversity in Malaysia and Singapore

Gastric Cancer (Biomarkers) Knowledgebase (GCBKB): A Curated and Fully Integrated Knowledgebase of Putative Biomarkers Related to Gastric Cancer

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