Gastric Cancer in Young Patients: Demographic, Clinicopathological, and Prognostic Factors in 92 Patients

Koea, Jonathan; Karpeh, Martin S.; Brennan, Murray F.

doi:10.1007/s10434-000-0346-9

Cited by 97 publications

(132 citation statements)

References 16 publications

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“…Our patients under 30 years old were much younger than those of other reports, which dealt the age of under 40 [9][10][11][12]15,18 or 35 13,14 years as the young group. Therefore, our present materials are considered to be more suitable for analysis of carcinogenesis of cancer in young patients.…”

Section: Intramucosal Gastric Cancer In the Youngcontrasting

confidence: 55%

“…In several studies, the clinicopathological features of gastric cancer in the young were somewhat different from ours. 1,2,[9][10][11][12][13][14]3,[15][16][17][18][19] With regard to histological type, poorly differentiated adenocarcinoma tends to be more frequent in young adults, [12][13][14]3 however, there is no difference in sex distribution between the young and elderly patients. 9,10,13,14 The discrepancy (b) Fifty-seven-year-old male subject (same case as a).…”

Section: Discussionmentioning

confidence: 99%

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Intramucosal gastric adenocarcinoma of poorly differentiated type in the young is characterized by Helicobacter pylori infection and antral lymphoid hyperplasia

et al. 2007

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The aim of this investigation was to clarify the histological characteristics of gastric cancer in the young. Twenty-three surgically resected specimens of young patients (under 30 years of age; young group) with intramucosal cancer of poorly differentiated type and 42 surgically resected specimens of elderly patients (more than 40 years of age; elderly group) with tumors of the identical depth and histological type were examined. The degree of gastritis and Helicobacter pylori (H. pylori) infection was evaluated according to the updated Sydney system. The incidence of H. pylori infection was significantly higher in the young group than in the elderly group (96 vs 36%, Po0.05). Within the background mucosa, antral chronic inflammatory infiltrates with lymphoid-follicle hyperplasia were more severe, and intestinal metaplasia was less frequent in the young group than in the elderly group. Glandular atrophy was not different between the two groups. Intramucosal gastric adenocarcinomas of poorly differentiated type in the young may be associated with H. pylori infection with antral chronic inflammation with lymphoid-follicle hyperplasia, regardless of the existence of intestinal metaplasia within the background gastric mucosa.

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Section: Intramucosal Gastric Cancer In the Youngcontrasting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Intramucosal gastric adenocarcinoma of poorly differentiated type in the young is characterized by Helicobacter pylori infection and antral lymphoid hyperplasia

et al. 2007

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“…However, few studies have reported that cancers are located in proximal (Koea et al, 2000;Lim et al, 2003) or middle (Nakamura et al, 1999) parts of the stomach.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological and p53 Gene Alteration Comparison between Young and Older Patients with Gastric Cancer

Karim¹

2014

Asian Pacific Journal of Cancer Prevention

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“…Even though we are not able to verify the exact evidence of these findings, this corresponds to previous reports that the predominance of signet ring cell in young gastric cancer patients (68% in 92 patients, 40 years of age or younger). 4 Unlike the characteristics of advanced-stage cancer patients, the percentage of tumors located in the lower third for patients at the early stage were 71.9%, which was higher than that reported in Japan, 3,6 China, 10 and Korea. 9 The percentages of tumors located in the middle and upper thirds were reported 41.4% and 20.1% in Japan, 6 similar to that reported in China (60.0% in the middle and upper thirds).…”

Section: Discussionmentioning

confidence: 59%

“…1,3 The incidence of gastric cancer in patients younger than 40 years ranges from 2.4% to 6.2%. [3][4][5][6] The clinicopathologic features of gastric cancer in young patients are different from those in older patients. It is considered that higher proportion of young patients have a histologically poorly differentiated type of cancer, female predominance, more aggressive tumor behavior, and metastatic disease at the time of diagnosis than older patients.…”

Section: Introductionmentioning

confidence: 99%

Clinical Outcomes of Endoscopic Submucosal Dissection in Patients under 40 Years Old with Early Gastric Cancer

Hahn

Lee

Park

et al. 2016

Korean J Helicobacter Up Gastrointest Res

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Background/Aims: The clinicopathologic features of gastric cancer in young patients are different from those of older patients. However, endoscopic submucosal dissection (ESD) is performed regardless of age. The purpose of this study was to characterize younger patients (≤40 years) who underwent ESD for early gastric cancer (EGC) and analyze the results of ESD. Materials and Methods: From January 2006 to June 2014, 55 patients aged 40 years or younger with newly diagnosed EGC underwent ESD at two tertiary hospitals. The clinicopathologic features of EGC and clinical outcomes of ESD in these young patients were reviewed retrospectively. Results: A total 55 patients with 57 EGC lesions underwent ESD. Female sex, superficial flat or depressed lesions, and undifferentiated histology were more common in younger patients than in older patients in our institutional ESD cohort. The en bloc resection rate was 92.7% and the complete resection rate was 94.5%. Although there was a high proportion of undifferentiated cancer in the younger patient group, the curative resection rate was 72.7%. Among 15 patients with non-curative resection, 4 patients underwent additional surgery and 1 patient underwent argon plasma coagulation at the ESD ulcer margin. Eight patients were placed under close surveillance without additional treatment, and no recurrent tumors developed, with a median follow-up period of 37.2±23.6 months. Conclusions: Younger EGC patients who underwent ESD showed the typical characteristics seen in younger patients with gastric cancer. ESD in younger EGC patients showed comparable outcomes to those in patients with undifferentiated EGC in general.

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Gastric Cancer in Young Patients: Demographic, Clinicopathological, and Prognostic Factors in 92 Patients

Abstract: The high frequency of a positive family history in young patients suggests an opportunity to identify a high-risk population for screening.

Cited by 97 publications

References 16 publications

Intramucosal gastric adenocarcinoma of poorly differentiated type in the young is characterized by Helicobacter pylori infection and antral lymphoid hyperplasia

Intramucosal gastric adenocarcinoma of poorly differentiated type in the young is characterized by Helicobacter pylori infection and antral lymphoid hyperplasia

Clinicopathological and p53 Gene Alteration Comparison between Young and Older Patients with Gastric Cancer

Clinical Outcomes of Endoscopic Submucosal Dissection in Patients under 40 Years Old with Early Gastric Cancer

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