Gastric Cancer Incidence and Mortality in French Guiana: South American or French?

Imounga, Laure Manuella; Plenet, Juliette; Belliardo, Sophie; Chine, Elie Chow; Louvel, Dominique; Cenciu, Béatrice; Couppié, Pierre; Alsibai, Kinan Drak

doi:10.1007/s12029-020-00572-z

Cited by 8 publications

(6 citation statements)

References 16 publications

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“…Gastric cancer (GC) is one of the malignant tumors of digestive tract with high degree of malignancy and accounts for some of the highest rates of cancer-associated high morbidity and mortality globally [ 1 , 2 ]. In fact, GC is the second most common cause of cancer-related mortality [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Long noncoding RNA NR2F1-AS1 plays a carcinogenic role in gastric cancer by recruiting transcriptional factor SPI1 to upregulate ST8SIA1 expression

Zuo

Zhang

et al. 2021

Bioengineered

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Gastric cancer (GC) is a highly malignant solid tumor of the digestive tract, which is associated with a high mortality rate. Long non-coding RNA (lncRNA) nuclear receptor subfamily 2 group F member 1 antisense RNA 1 (NR2F1-AS1) has been reported to exert a tumor-promoting effect in some types of cancer. The present study aimed to investigate the role of NR2F1-AS1 in GC. The expression levels of NR2F1-AS1 and its potential target gene were measured in GC cell lines. Bioinformatics analysis, an RNA immunoprecipitation assay and a chromatin immunoprecipitation assay were used to determine the binding relationship between NR2F1-AS1 and downstream genes. The effect of NR2F1-AS1 regulatory axis on AGC cell viability, proliferation, migration, invasion and epithelial-mesenchymal transition was evaluated. The results of the present study revealed that the knockdown of NR2F1-AS1 inhibited the proliferation, invasion and migration of GC cells. NR2F1-AS1 also upregulated the expression levels of ST8SIA1 by recruiting transcriptional factor SPI1. Thus, the effects of the knockdown of NR2F1-AS1 on GC cell functions were suggested to occur via regulation of ST8SIA1. In conclusion, the findings of the current study indicated that NR2F1-AS1 may promote the proliferation, invasion and migration of GC cells by recruiting SPI1, to upregulate ST8SIA1 expression. Thus, the regulation of their expression levels may provide a novel direction for the treatment of GC.

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Section: Introductionmentioning

confidence: 99%

Long noncoding RNA NR2F1-AS1 plays a carcinogenic role in gastric cancer by recruiting transcriptional factor SPI1 to upregulate ST8SIA1 expression

Zuo

Zhang

et al. 2021

Bioengineered

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“…Apart from COVID-19, the infectious pathogen with the greatest burden of disease in the past 40 years has been HIV/AIDS, notably HIV-associated disseminated histoplasmosis, but mortality has considerably dropped ( 20 ). Infectious pathogens such as HPV ( 21 ), HTLV-1 ( 12 ), and H. pylori ( 22 ) have a substantial impact on infection-mediated cancers. Perhaps one of the major health consequences of infectious pathogens concerns pregnant women and their fetuses ( 14 , 15 , 18 , 23–25 ).…”

Section: Resultsmentioning

confidence: 99%

Contrasted life trajectories: reconstituting the main population exposomes in French Guiana

Nacher,

Basurko,

Douine

et al. 2024

Front. Public Health

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In French Guiana, life expectancy is between 2 and 3 years below that of France, reflecting differences in mortality rates that are largely sensitive to primary healthcare and thus preventable. However, because poverty affects half of the population in French Guiana, global measurements of life expectancy presumably conflate at least two distinct situations: persons who have similar life expectancies as in mainland France and persons living in precariousness who have far greater mortality rates than their wealthier counterparts. We thus aimed to synthesize what is known about statistical regularities regarding exposures and sketch typical French Guiana exposomes in relation to health outcomes. We conducted a narrative review on common exposures in French Guiana and made comparisons between French Guiana and mainland France, between rich and poor in French Guiana, and between urban and rural areas within French Guiana. The most striking fact this panorama shows is that being a fetus or a young child in French Guiana is fraught with multiple threats. In French Guiana, poverty and poor pregnancy follow-up; renouncing healthcare; wide variety of infectious diseases; very high prevalence of food insecurity; psychosocial stress; micronutrient deficiencies; obesity and metabolic problems; and frequent exposure to lead and mercury in rural areas constitute a stunningly challenging exposome for a new human being to develop into. A substantial part of the population’s health is hence affected by poverty and its sources of nutrition.

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“…Although cancers are overall less frequent, infection-related cancers (notably cervix and stomach) are more frequent in French Guiana than in mainland France [14][15][16]. However, the transition towards chronic diseases is well underway with a decline of infectious diseases-not only of HIV-and a greater burden of circulatory and metabolic diseases in French Guiana than in mainland France.…”

Section: Discussionmentioning

confidence: 99%

The Epidemiologic Transition in French Guiana: Secular Trends and Setbacks, and Comparisons with Continental France and South American Countries

et al. 2023

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There are great variations between population subgroups, notably in poorer countries, leading to substantial inconsistencies with those predicted by the classical epidemiologic transition theory. In this context, using public data, we aimed to determine how the singular case of French Guiana fit and transitioned in the epidemiologic transition framework. The data show a gradual decline in infant mortality to values above 8 per 1000 live births. Premature mortality rates were greater but declined more rapidly in French Guiana than in mainland France until 2017 when they reascended in a context of political turmoil followed by the COVID-19 pandemic and strong reluctance to get vaccinated. Although infections were a more frequent cause of death in French Guiana, there is a marked decline and circulatory and metabolic causes are major causes of premature death. Fertility rates remain high (>3 live births per woman), and the age structure of the population is still pyramid-shaped. The singularities of French Guiana (rich country, universal health system, widespread poverty) explain why its transition does not fit neatly within the usual stages of transition. Beyond gradual improvements in secular trends, the data also suggest that political turmoil and fake news may have detrimentally affected mortality in French Guiana and reversed improving trends.

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Gastric Cancer Incidence and Mortality in French Guiana: South American or French?

Cited by 8 publications

References 16 publications

Long noncoding RNA NR2F1-AS1 plays a carcinogenic role in gastric cancer by recruiting transcriptional factor SPI1 to upregulate ST8SIA1 expression

Long noncoding RNA NR2F1-AS1 plays a carcinogenic role in gastric cancer by recruiting transcriptional factor SPI1 to upregulate ST8SIA1 expression

Contrasted life trajectories: reconstituting the main population exposomes in French Guiana

The Epidemiologic Transition in French Guiana: Secular Trends and Setbacks, and Comparisons with Continental France and South American Countries

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