2018
DOI: 10.3389/fimmu.2018.02546
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Gastric Cancer Is the Leading Cause of Death in Italian Adult Patients With Common Variable Immunodeficiency

Abstract: An increased prevalence of malignant lymphoma and of gastric cancer has been observed in large cohorts of patients with common variable immunodeficiency (CVID), the most frequently symptomatic primary immunodeficiency. Surveillance strategies for cancers in CVID should be defined based on epidemiological data. Risks and mortality for cancers among 455 Italian patients with CVID were compared to cancer incidence data from the Italian Cancer Registry database. CVID patients showed an increased cancer incidence f… Show more

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Cited by 57 publications
(87 citation statements)
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References 29 publications
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“…One of these two patients, in particular, initially presented a reduction of both light chains and subsequently developed a significant increase of circulating lambda chain, with no detectable paraprotein and was eventually diagnosed a NHL. This suggests that sFLC assay might also be an effective tool in the follow-up strategy in a population with a well-known risk of hematological malignancies (4,24,25).…”
Section: Discussionmentioning
confidence: 99%
“…One of these two patients, in particular, initially presented a reduction of both light chains and subsequently developed a significant increase of circulating lambda chain, with no detectable paraprotein and was eventually diagnosed a NHL. This suggests that sFLC assay might also be an effective tool in the follow-up strategy in a population with a well-known risk of hematological malignancies (4,24,25).…”
Section: Discussionmentioning
confidence: 99%
“…It has been widely recognized that gastrointestinal infections and chronic intestinal inflammation are common in CVID (34)(35)(36) and are associated with high morbidity (37). Moreover, CVID patients have an increased risk of gastric cancer (38), and therefore surveillance gastroscopy with collection of biopsies is regularly performed in our center according to the Italian guidelines (www.ipinet.org). We excluded from the study CVID patients with a histological report of an abnormal tissue architecture (i.e., villous atrophy).…”
Section: Detailed Gastrointestinal Diagnosis and Gut Alteration Have mentioning
confidence: 99%
“…In contrast with hematological and gastrointestinal mucosal malignancies, very few data are available about prevalence, distribution and outcome of liver cancers in CVID. Four cases of liver cancer were found in an Italian cohort of 455 adult patients (prevalence 0.95%), corresponding to a Standardized Incidence Ratio (SIR) of 1.9 (95% CI 0.3-5.6) in comparison to the Italian National Cancer Registry (Associazione Italiana Registro Tumori -AIRTUM) data (22). Noteworthy, all four patients died and liver cancer accounted for the 5.1% all death in the cohort.…”
Section: Malignanciesmentioning
confidence: 94%
“…Compelling evidence suggests a higher cumulative incidence of malignancy in CVID population (widely ranging from 1.5% to 25.5%), with a peak of incidence between the 4th and 6th decade of life (76). Non-Hodgkin lymphomas are the most common type of malignancy in several cohort studies (23), even though epithelial cancers are associated with a higher mortality ratio and gastric cancer has recently emerged as the leading cause of death in a large multicenter Italian study (22,77). The pathogenetic mechanisms underlying cancer development in CVID are not completely understood.…”
Section: Malignanciesmentioning
confidence: 99%
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