Gastric cancer: past progress and present challenges

Sjoquist, Katrin Marie; Zalcberg, John

doi:10.1007/s10120-014-0437-0

Cited by 8 publications

(8 citation statements)

References 42 publications

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“…Over the past 10 years, great progress has been made in cancer research in terms of cancer-initiation mechanisms, new drug discovery, and therapeutic modes. 1 We also found a number of signaling pathways that affect the development of gastric cancer, including human epidermal growth factor receptor 2 pathway, epidermal growth factor receptor pathway, vascular endothelial growth factor receptor pathway, HGF/c-Met pathway, and PD1/PD-L1 pathway. 2 There are many drugs targeting these signaling pathways, some of which have showed survival benefit and have been used in clinical practice (trastuzumab, ramucirumab).…”

Section: Introductionmentioning

confidence: 72%

The expression of the PI3K/AKT/mTOR pathway in gastric cancer and its role in gastric cancer prognosis

Ying¹,

Xu²,

Liu³

et al. 2015

OTT

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ObjectiveTo analyze the correlation between sequential aspects of the phosphoinositide-3 kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway by immunohistochemistry in the primary lesion of gastric cancer, clinicopathologic factors, and survival in Chinese patients to explore the role of sequential analysis of multiple targets in prognoses.MethodsImmunohistochemistry was performed to examine the expression of PI3K, phosphorylated-AKT (p-AKT), and phosphorylated-mTOR (p-mTOR) in 59 primary lesion samples ranging from Stages I to IV after gastrectomy. The correlation between sequential expression of multiple targets, and clinicopathologic factors and survival was analyzed.ResultsThe positive expression rates of PI3K, p-AKT, and p-mTOR were 49%, 58%, and 56%, respectively. There were eleven cases with three biomarkers positive (19%), 22 cases with two biomarkers positive (37%), and 19 cases with only one biomarker positive (32%). Seven cases (12%) were all negative. Multi-factorial Cox regression analysis showed that neural invasion, vascular invasion, size of the tumor, lymph nodes affected, metastasis, carbohydrate antigen 19-9 level, and PI3K/p-AKT/p-mTOR simultaneous expression were independent prognostic parameters. The risk of death for the cases with two biomarkers positive was 0.367 times that for the cases with three biomarkers positive (P=0.166). The risk of death for the cases with only one biomarker positive was 0.105 times that for the cases with three biomarkers positive (P=0.058). The risk of death for the cases with three biomarkers negative was 0.017 times that for the cases with three biomarkers positive (P=0.022).ConclusionOur study generated the hypothesis that patients with gastric cancer with simultaneous expression of PI3K/p-AKT/p-mTOR had worse outcome. But we need more rigorous validation in a larger data set.

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Section: Introductionmentioning

confidence: 72%

The expression of the PI3K/AKT/mTOR pathway in gastric cancer and its role in gastric cancer prognosis

Ying¹,

Xu²,

Liu³

et al. 2015

OTT

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show abstract

“…1 We also found a number of signaling pathways that affect the development of gastric cancer, including human epidermal growth factor receptor 2 pathway, epidermal growth factor receptor pathway, vascular endothelial growth factor receptor pathway, HGF/c-Met pathway, and PD1/PD-L1 pathway. 2 There are many drugs targeting these signaling pathways, some of which have showed survival benefit and have been used in clinical practice (trastuzumab, ramucirumab).…”

Section: Introductionmentioning

confidence: 72%

2381 The expression of the PI3K/AKT/mTOR pathway in gastric cancer and its role in gastric cancer prognosis

Ying¹,

He²,

Sun³

et al. 2015

European Journal of Cancer

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“…Great progress has been made in the study of cancer including the mechanism of cancer, drug discovery and therapeutic modes, during the past 10 years ( 1 ). However, gastric cancer (GC) is one of the most common malignancies ( 2 , 3 ), and the 5-year survival rate of GC patients remains very low ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

Fibrinogen‑like‑protein 1 promotes the invasion and metastasis of gastric cancer and is associated with poor prognosis

et al. 2018

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The protective role of fibrinogen-like-protein 1 (FGL1) in liver injury has been reported previously. However, there are few studies on FGL1 expression in gastric cancer (GC) tissues, and the role of FGL1 in GC remains unclear. The aim of the present study was to investigate the correlation between FGL1 expression and prognosis in GC patients. Data was downloaded from The Cancer Genome Atlas database, and 50 pairs of GC tissues and the corresponding non-tumor tissues were collected between 2008 to 2011. Furthermore, FGL1 expression was silenced in order to explore its role in SGC-7901 cell proliferation, invasion and migration using Cell Counting Kit-8, wound healing, Transwell invasion and migration assays, respectively. Finally, whether FGL1 is involved in epithelial-mesenchymal transition (EMT) regulation in SGC-7901 cells was determined by western blotting. The results revealed that FGL1 expression was upregulated in GC tissues, and the overall survival time of GC patients with high FGL1 expression levels was markedly shorter than that of GC patients with low FGL1 expression levels (P=0.005). In addition, silencing FGL1 significantly inhibited SGC-7901 cell proliferation, invasion and migration in vitro. Finally, western blot analyses indicated that knockdown of FGL1 markedly increased E-cadherin expression levels (P<0.01), and significantly decreased N-cadherin (P<0.01) and vimentin expression levels (P<0.01), thereby suggesting that FGL1 may promote EMT. These results indicated that FGL1 has the potential to be a predictor in GC patients as well as a target for the treatment of GC.

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Gastric cancer: past progress and present challenges

Cited by 8 publications

References 42 publications

The expression of the PI3K/AKT/mTOR pathway in gastric cancer and its role in gastric cancer prognosis

The expression of the PI3K/AKT/mTOR pathway in gastric cancer and its role in gastric cancer prognosis

2381 The expression of the PI3K/AKT/mTOR pathway in gastric cancer and its role in gastric cancer prognosis

Fibrinogen‑like‑protein 1 promotes the invasion and metastasis of gastric cancer and is associated with poor prognosis

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