2018
DOI: 10.3892/ol.2018.7990
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Gastric cancer patients have elevated plasmacytoid and CD1c+ dendritic cells in the peripheral blood

Abstract: Abstract. Dendritic cells (DCs) are important in tumor immunology. Identifying DC subset markers in the peripheral blood, which are informative for gastric cancer stages, is not only useful for prognosis but may also provide mechanistic insights into processes facilitating therapy. The present study investigated plasmacytoid dendritic cells (pDCs) and myeloid CD1c + dendritic cells (mDC1s) in the peripheral blood of patients with gastric cancer and healthy controls using flow cytometry. Using peripheral DC sta… Show more

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Cited by 24 publications
(27 citation statements)
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“…Moreover, prostate cancer patients have shown a marked reduction in circulating DCs . Liu et al, also reported that peripheral DC2s may be an important prognostic factor for patients with gastric carcinoma at different stages . In the current study, lower levels of peripheral DC2s were found in more advanced T stage gastric cancers, where patients with lower peripheral DC2 levels had poorer prognoses.…”
Section: Discussionsupporting
confidence: 60%
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“…Moreover, prostate cancer patients have shown a marked reduction in circulating DCs . Liu et al, also reported that peripheral DC2s may be an important prognostic factor for patients with gastric carcinoma at different stages . In the current study, lower levels of peripheral DC2s were found in more advanced T stage gastric cancers, where patients with lower peripheral DC2 levels had poorer prognoses.…”
Section: Discussionsupporting
confidence: 60%
“…26 Liu et al, also reported that peripheral DC2s may be an important prognostic factor for patients with gastric carcinoma at different stages. 1 In the current study, lower levels of peripheral DC2s were found in more advanced T stage gastric cancers, where patients with lower peripheral DC2 levels had poorer prognoses. In a previous study, it was also found that certain activated DC2s are able to initiate antitumor immunoreactions.…”
Section: Discussionsupporting
confidence: 47%
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“…An accumulation of plasmacytoid DCs has also been observed in metastasis from other malignancies, such as BC [ 131 ] and melanoma [ 132 ]. Moreover, in the peripheral blood from gastric cancer patients, the number of these cells increased in the case of advanced disease and presence of lymph node metastasis [ 133 ].…”
Section: Immune-surveillance and Immune-support Of Ctcsmentioning
confidence: 99%