Gastric cancer: <scp>A</scp>ustralian outcomes of multi‐modality treatment with curative intent

Chen, Yufei; Awan, Nida; Haveman, Jan Willem; Apostolou, Christos; Chang, David K.; Merrett, Neil D.

doi:10.1111/ans.12693

Cited by 3 publications

(2 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This study comprised a heterogeneous group with resectable adenocarcinoma of the distal oesophagus and stomach. Although surgical treatment of oesophageal and gastric cancers occurs in relatively low volume centres in Australia, we have equivalent short and long term outcomes compared to Asian and European institutions [22, 23]. Therefore, our findings on the predictive performance of PET for survival and PR in this group are applicable to other populations.…”

Section: Discussionmentioning

confidence: 62%

Serial imaging using [18F]Fluorodeoxyglucose positron emission tomography and histopathologic assessment in predicting survival in a population of surgically resectable distal oesophageal and gastric adenocarcinoma following neoadjuvant therapy

et al. 2017

View full text Add to dashboard Cite

Background and objectivesWe retrospectively evaluated the value of PET/CT in predicting survival and histopathological tumour-response in patients with distal oesophageal and gastric adenocarcinoma following neoadjuvant treatment.MethodsTwenty-one patients with resectable distal oesophageal adenocarcinoma and 14 with gastric adenocarcinoma between January 2002 and December 2011, who had undergone serial PET before and after neoadjuvant therapy followed by surgery, were enrolled. Maximum standard uptake value (SUVmax) and metabolic tumour volume were measured and correlated with tumour regression grade and survival.ResultsHistopathological tumour response (PR) is a stronger predictor of overall and disease-free survival compared to metabolic response. ∆%SUVmax ≥70% was the only PET metric that predicted PR (82.4% sensitivity, 61.5% specificity, p = 0.047). Histopathological non-responders had a higher risk of death (HR 8.461, p = 0.001) and recurrence (HR 6.385, p = 0.002) and similarly in metabolic non-responders for death (HR 2.956, p = 0.063) and recurrence (HR 3.614, p = 0.028). Ordinalised ∆%SUVmax showed a predictive trend for OS and DFS, but failed to achieve statistical significance.ConclusionsPR was a stronger predictor of survival than metabolic response. ∆%SUVmax ≥70% was the best biomarker on PET that predicted PR and survival in oesophageal and gastric adenocarcinoma. Ordinalisation of ∆%SUVmax was not helpful in predicting primary outcomes.

show abstract

Section: Discussionmentioning

confidence: 62%

Serial imaging using [18F]Fluorodeoxyglucose positron emission tomography and histopathologic assessment in predicting survival in a population of surgically resectable distal oesophageal and gastric adenocarcinoma following neoadjuvant therapy

et al. 2017

View full text Add to dashboard Cite

show abstract

“…This unsurprisingly leads to an overall poor prognosis for GC. Five-year survival rates have been quoted ranging from 36-47% in large Western trials (5), with other sources quoting as low as 20% overall and 5% for metastatic disease (6).…”

Section: Introductionmentioning

confidence: 99%

An assessment of candidate genes to assist prognosis in gastric cancer

McFarlane

Brettschneider

Gelsthorpe

et al. 2018

J. Gastrointest. Oncol.

View full text Add to dashboard Cite

show abstract

The role of cullin proteins in gastric cancer

Chen

Yao²

2015

Tumor Biol.

View full text Add to dashboard Cite

The cullin proteins are a family of scaffolding proteins that associate with RING proteins and ubiquitin E3 ligases and mediate substrate-receptor bindings. Thus, cullin proteins regulate the specificity of ubiquitin targeting in the regulation of proteins involved in various cellular processes, including proliferation, differentiation, and apoptosis. There are seven cullin proteins that have been identified in eukaryotes: CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5, and CUL7/p53-associated parkin-like cytoplasmic protein. All of these proteins contain a conserved cullin homology domain that binds to RING box proteins. Cullin-RING ubiquitin ligase complexes are activated upon post-translational modification by neural precursor cell-expressed, developmentally downregulated protein 8. The aberrant expression of several cullin proteins has been implicated in many cancers though the significance in gastric cancer has been less well investigated. This review provides the first systematic discussion of the associations between all members of the cullin protein family and gastric cancer. Functional and regulatory mechanisms of cullin proteins in gastric carcinoma progression are also summarized along with a discussion concerning future research areas. Accumulating evidence suggests a critical role of cullin proteins in tumorigenesis, and a better understanding of the function of these individual cullin proteins and their targets will help identify potential biomarkers and therapeutic targets.

show abstract

Gastric cancer: Australian outcomes of multi‐modality treatment with curative intent

Cited by 3 publications

References 17 publications

Serial imaging using [18F]Fluorodeoxyglucose positron emission tomography and histopathologic assessment in predicting survival in a population of surgically resectable distal oesophageal and gastric adenocarcinoma following neoadjuvant therapy

Serial imaging using [18F]Fluorodeoxyglucose positron emission tomography and histopathologic assessment in predicting survival in a population of surgically resectable distal oesophageal and gastric adenocarcinoma following neoadjuvant therapy

An assessment of candidate genes to assist prognosis in gastric cancer

The role of cullin proteins in gastric cancer

Contact Info

Product

Resources

About