Gastric Cancer Screening Methods: A Comparative Study of the Chinese New Gastric Cancer Screening Score and Kyoto Classification of Gastritis

Liu, Xiao-Ming; Ma, Xiao-Yu; Liu, Fen; Liu, Zhi-Ling; Tang, Xiangyu; Ji, Ming-Zhu; Zheng, Jinxin

doi:10.1155/2022/7639968

Cited by 10 publications

(14 citation statements)

References 21 publications

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“…The development of tools for the early detection of GC is important for reducing mortality, increasing survival rates, and improving quality of life [ 23 , 24 ]. Gastroscopy (with biopsies) is commonly accepted as the gold standard for detecting GC, but its application in the large-scale screening of GC is limited by its invasiveness and by an insufficient supply of endoscopy professionals and facilities [ 25 , 26 ]. Therefore, it is urgent to develop novel, simple, cost-effective, and manipulable screening methods for GC.…”

Section: Discussionmentioning

confidence: 99%

Application of a novel scoring system for gastric cancer opportunistic screening in hospital visits

et al. 2022

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Background A novel scoring system and screening procedure for gastric cancer (GC) screening was proposed based on the national conditions of China, which state that endoscopy professionals and facilities are relatively limited compared with the large Chinese population. Methods A novel scoring system for gastric cancer screening was used to retrospectively analyse the patients who met the screening procedure from April 2017 to December 2019 in our hospital. We divided all of the patients into three groups: low-risk group (0–11 scores), medium-risk group (12–16 scores), and high-risk group (17–23 scores). Statistical analysis was performed on the detection rate of gastric cancer and precursors of gastric cancer among these three groups. Results A total of 6701 patients were enrolled in this study, including 4,352(64.95%) in the low-risk group, 1,948 patients (29.07%) in the medium-risk group, and 401 patients (5.98%) in the high-risk group. The total detection rate of gastric cancer was 2.84% (190/6,701), with a 0.94% rate (41/4,352) in the low-risk group, a 5.18% rate (101/1,948) in the medium-risk group, and a 11.97% rate (48/401) in the high-risk group. There were statistically significant differences in the detection rate of gastric cancer among these three groups (all P < 0.05). The detection rate of early gastric cancer was 46.31% (88/190) among all of the detected gastric cancers in this study. In addition, the detection rates of differentiated gastric cancer and precursors of gastric cancer in the medium-risk group and high-risk group were significantly higher than those in the low-risk group. In addition, the area under the curve (AUC) of the receiver operating characteristic curve (ROC) of the novel scoring system in differentiating GC was 0.79. Conclusion The screening strategy based on the novel scoring system can significantly improve the efficiency of gastric cancer opportunistic screening in hospital visits. Gastroscopy should be strongly recommended for patients in the medium-risk group and high-risk group, and detailed gastroscopy should be adopted as early as possible to improve the detection rate of early gastric cancer.

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Section: Discussionmentioning

confidence: 99%

Application of a novel scoring system for gastric cancer opportunistic screening in hospital visits

et al. 2022

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“…The area under the curve (AUC) of the total Kyoto score for predicting current infection was 0.85, with a cutoff value of 2[ 27 ]. Current infection rates increased stepwise, with total Kyoto scores of 0-1, 2-3, and ≥ 4 (8.6%, 61.4%, and 85.7%, respectively)[ 31 ]. The mean total Kyoto scores differed among patients with current, past, and non-infection (3.4, 1.1, and 0.0, respectively)[ 32 ].…”

Section: H Pylori Infection In the Kyoto Classificationmentioning

confidence: 99%

Kyoto classification of gastritis: Advances and future perspectives in endoscopic diagnosis of gastritis

Toyoshima¹,

Nishizawa²

2022

World J Gastroenterol

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This editorial provides an update of the recent evidence on the endoscopy-based Kyoto classification of gastritis, clarifying the shortcomings of the Kyoto classification, and providing prospects for future research, with particular focus on the histological subtypes of gastric cancer (GC) and Helicobacter pylori ( H. pylori ) infection status. The total Kyoto score is designed to express GC risk on a score ranging from 0 to 8, based on the following five endoscopic findings: Atrophy, intestinal metaplasia (IM), enlarged folds (EF), nodularity, and diffuse redness (DR). The total Kyoto score reflects H. pylori status as follows: 0, ≥ 2, and ≥ 4 indicate a normal stomach, H. pylori -infected gastritis, and gastritis at risk for GC, respectively. Regular arrangement of collecting venules (RAC) predicts non-infection; EF, nodularity, and DR predict current infection; map-like redness (MLR) predicts past infection; and atrophy and IM predict current or past infection. Atrophy, IM, and EF all increase the incidence of H. pylori -infected GC. MLR is a specific risk factor for H. pylori -eradicated GC, while RAC results in less GC. Diffuse-type GC can be induced by active inflammation, which presents as EF, nodularity, and atrophy on endoscopy, as well as neutrophil and mononuclear cell infiltration on histology. In contrast, intestinal-type GC develops via atrophy and IM, and is consistent between endoscopy and histology. However, this GC risk-scoring design needs to be improved.

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“…Upper gastrointestinal cancer (UGC), including gastric cancer (GC), esophagogastric junction cancer (EJC) and esophageal cancer (EC), represent more than 8.7% (1,693,203) of new cancer cases and about 13.2% (1,312,869) of cancer-related deaths worldwide in 2020 [ 1 ]. China is the country that suffers the heaviest disease burden of UGC, with more than 40% of new cases and deaths of GC in the world found in China ever year [ 2 ], and almost half of the new EC cases all over the world occurring in China [ 3 ]. Due to the fact that most UGCs were diagnosed and treated at an advanced stage, the average five-year survival rate for UGC is only about 10–30% [ 2 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…China is the country that suffers the heaviest disease burden of UGC, with more than 40% of new cases and deaths of GC in the world found in China ever year [ 2 ], and almost half of the new EC cases all over the world occurring in China [ 3 ]. Due to the fact that most UGCs were diagnosed and treated at an advanced stage, the average five-year survival rate for UGC is only about 10–30% [ 2 , 4 ]. However, if the UGCs were detected at an early stage, the five-year survival rate can be as high as 90% [ 2 ] and most of them can be curatively treated by endoscopy [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

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A Novel Plasma-Based Methylation Panel for Upper Gastrointestinal Cancer Early Detection

Peng

Zhao

Pei

et al. 2022

Cancers

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Background: Upper gastrointestinal cancer (UGC) is an important cause of cancer death in China, with low five-year survival rates due to the majority of UGC patients being diagnosed at an advanced stage. Therefore, there is an urgent need to develop cost-effective, reliable and non-invasive methods for the early detection of UGC. Methods: A novel plasma-based methylation panel combining simultaneous detection of three methylated biomarkers (ELMO1, ZNF582 and TFPI2) and an internal control gene were developed and used to examine plasma samples from 186 UGC patients and 190 control subjects. Results: The results indicated excellent PCR amplification efficiency and reproducibility of ELMO1, ZNF582 and TFPI2 in the range of 10–100,000 copies per PCR reaction of fully methylated genomic DNA. The methylation levels of ELMO1, ZNF582 and TFPI2 were significantly higher in UGC samples than those in control subjects. The sensitivities of ELMO1, ZNF582 and TFPI2 alone for UGC detection were 32.3%, 61.3% and 30.6%, respectively; when three markers were combined, the sensitivity was improved to 71.0%, with a specificity of 90.0%, and the area under the curve (AUC) was 0.870 (95% CI: 0.832–0.902). Conclusion: Methylated ELMO1, ZNF582 and TFPI2 were specific for UGC and the three-methylated gene panel provided an alternative non-invasive choice for UGC early detection.

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Gastric Cancer Screening Methods: A Comparative Study of the Chinese New Gastric Cancer Screening Score and Kyoto Classification of Gastritis

Cited by 10 publications

References 21 publications

Application of a novel scoring system for gastric cancer opportunistic screening in hospital visits

Application of a novel scoring system for gastric cancer opportunistic screening in hospital visits

Kyoto classification of gastritis: Advances and future perspectives in endoscopic diagnosis of gastritis

A Novel Plasma-Based Methylation Panel for Upper Gastrointestinal Cancer Early Detection

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