Gastric Carcinoma—A Big Challenge in a Poor Economy

Osime, OC; Momoh, MI; Irowa, Omorodion; Obumse, A.

doi:10.1007/s12029-009-9118-3

Cited by 7 publications

(4 citation statements)

References 15 publications

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“…Post-operative mortality from this study was 11.5%, which is lower than the 23-36% previously reported from Nigeria. 9,14,28,29 The fewer patients in this study may have been responsible for this finding.…”

Section: Discussionmentioning

confidence: 73%

“…This observation is similar to other reports from Nigeria. 8,9 Recently, due to improvement in diagnostic facilities, the diagnosis of early gastric cancer has increased. In Japan, the diagnosis of early gastric cancer is about 50% of patients with gastric cancer while in Korea, the proportion has increased from 28.6% in 1995 to 47.4% in 2004.…”

Section: Discussionmentioning

confidence: 99%

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Clinicopathological features and management of gastric cancer in Port Harcourt

Manuel

Danagogo

2020

Int Surg J

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Background: Gastric cancer is a relatively common cancer and has been documented as the 5th commonest cancer worldwide and the 3rd leading cause of cancer death. Surgery is the treatment of choice for operable cases while chemotherapy. It has a poor prognosis with a relative overall 5-year survival rate of 18%.Methods: This is a retrospective study of all patients that presented with gastric cancer to University of Port Harcourt Teaching Hospital between 1st January 2008 to 31st December 2017. Data were extracted and analyzed using the Statistical Package for Social Sciences (SPSS).Results: There were 14 males and 12 females seen within the study period making a male to female ratio of 1.2:1. Their ages ranged from 35 to 75 years with a mean of 54.7±4.8 years. The peak age incidence is in the 61-70-year age range. Four patients had curative surgery (D2 sub total gastrectomy) while 6 patients (23.1%) had D1 sub total gastrectomy. Post-operative complications occurred in 7 patients (26.9%). And the commonest was surgical site infection, seen in 4 patients (15.4%). Three patients died giving a mortality rate of 11.5%.Conclusions: Most patients with gastric cancer present with advance disease. The choice of treatment should be based on patient’s fitness, survival benefit and after an accurate assessment of extent of disease.

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Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Clinicopathological features and management of gastric cancer in Port Harcourt

Manuel

Danagogo

2020

Int Surg J

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“…Delays in referrals result in more advanced disease presentation that can necessitate palliative, rather than curative surgery. In Nigeria, patients with gastric malignancies commonly present with advanced tumors, limiting the use of partial gastrectomy and jejunostomy . Only 37% of patients in our study underwent a distal gastrectomy.…”

Section: Discussionmentioning

confidence: 80%

“…In Nigeria, patients with gastric malignancies commonly present with advanced tumors, limiting the use of partial gastrectomy and jejunostomy. 24 Given limited diagnostic and treatment modalities, increased awareness and education of providers may improve diagnostic delays without significantly impacting outcomes. However, implementation of these educational programs and their impact on time to curative surgery will require further investigation as this is one potential avenue for improving outcomes in patients with gastric cancer in Rwanda.…”

Section: By Comparison In the United States Between 2004 And 2009 Overmentioning

confidence: 99%

Impact of delayed care on surgical management of patients with gastric cancer in a low‐resource setting

Martin

Silverstein

Ssebuufu

et al. 2018

Journal of Surgical Oncology

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Background: Gastric cancer is the fifth most common cancer in Eastern Africa. Diagnostic delays in low-resource countries result in advanced disease presentation. We describe perioperative management of gastric cancer in Rwanda. Methods: Retrospective review of records at three hospitals was performed to identify gastric adenocarcinoma cases from January 2012 – June 2016. Multiple perioperative and tumor-related variables were collected. Descriptive and bi-variate analyses were performed. Results: Final analysis included 229 patients with gastric cancer. Median age was 58 years (IQR 49–65) and 49.6% were female (n=114). Patients reported symptoms (i.e., weight loss, epigastric pain) for median time of 12 months (IQR 7.5–24). On presentation, 18.8% (n=43) had gastric outlet obstruction; 13.5% (n=31) had a palpable mass. Fifty-one percent (n=117) underwent an operation; of these, 74% (n=86) received gastrojejunostomy or were inoperable; 29% (n=34) underwent curative resection. Palliative care referrals were made for 9% (n=20). Pathology reports were available for 190 patients (83.0%). Only 11.3% (n=26) had H. pylori testing, and 65.4% tested positive (n=17). Conclusions: A majority of patients presented with advanced disease. Very few patients had a curative resection. Significant advances in diagnosis and treatment are needed to improve care of gastric cancer in Rwanda.

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Gastric Cancer at a Nigerian Tertiary Referral Center: Experiences With Establishing an Institutional Cancer Registry

Yibrehu,

Mohammed,

Murthy

et al. 2024

Journal of Surgical Oncology

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BackgroundIn Nigeria, gastric cancer is the 10th most common and 9th most deadly malignancy. The limited availability of robust data makes further characterizing it challenging. The objective of this study was to assess the presentation, and management of gastric cancer in Nigeria using an institutional cancer registry.MethodsWe reviewed a prospective database of patients diagnosed with any gastric cancer at a single tertiary referral center over 15 years (2007–2022). Patients with suspected gastric cancer were surveyed for sociodemographics and then added to the institutional gastric cancer registry. Thereafter, periodic chart review and phone call was used to obtain investigation results, and survival data, respectively. Only patients with complete histopathology were included in analysis.Results138 patients met inclusion criteria (mean age 55.3 years, 68.8% male). Patients typically presented with weight loss (119, 86.2%) and anorexia (92, 66.7%). Blood work (132, 95.7%) and ultrasound (80, 57.9%) were the most common investigations. Most fully staged patients presented with metastatic disease (39, 90.2%). Patients underwent at least one treatment modality (109, 79.0%), and most 54 (49.5%) underwent both chemotherapy and surgery. Patients undergoing surgery usually had resection of their tumor (58, 67.4%). The median time of follow‐up was 45.6 months, and 51.4% (71) of patients were dead at that time point.ConclusionOur gastric cancer database identified that most patients present with advanced disease and are undergoing at least one treatment modality. The next steps include initiatives to strengthen the quality of registry data, identify high‐risk patients, and provide timely treatment.

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Gastric Carcinoma—A Big Challenge in a Poor Economy

Abstract: Most of the cases of gastric carcinoma presented in this study presented late with associated significant mortality. Health education is advised with a view to encouraging early presentation.

Cited by 7 publications

References 15 publications

Clinicopathological features and management of gastric cancer in Port Harcourt

Clinicopathological features and management of gastric cancer in Port Harcourt

Impact of delayed care on surgical management of patients with gastric cancer in a low‐resource setting

Gastric Cancer at a Nigerian Tertiary Referral Center: Experiences With Establishing an Institutional Cancer Registry

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