Gastric carcinoma in canines and humans, a review

Hugen, S.; Thomas, Rachel; German, Alexander J.; Burgener, Iwan; Mandigers, Paul J. J.

doi:10.1111/vco.12249

Cited by 34 publications

(59 citation statements)

References 114 publications

(157 reference statements)

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“…In humans and dogs, adenocarcinoma is malignant and epithelial in origin, and infiltrates submucosal areas . In dogs, adenocarcinoma is often located in small curvature and pylorus . In humans, the main CT findings of gastric carcinoma are local or diffuse gastric wall thickenings with variable enhancement and intraluminal soft tissue mass .…”

Section: Discussionmentioning

confidence: 99%

“…2,24 In dogs, adenocarcinoma is often located in small curvature and pylorus. 25 In humans, the main CT findings of gastric carcinoma are local or diffuse gastric wall thickenings with variable enhancement and intraluminal soft tissue mass. 24,26 It is not possible to differentiate gastric lymphoma from adenocarcinoma based on the CT appearance of the stomach alone.…”

Section: Discussionmentioning

confidence: 99%

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Contrast‐enhanced computed tomography may be helpful for characterizing and staging canine gastric tumors

Tanaka

Akiyoshi

Mie

et al. 2018

Vet Radiology Ultrasound

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In humans, computed tomography (CT) is a widely performed technique for the diagnosis and staging of gastric tumors. The purpose of this retrospective case series study was to describe CT findings in a group of dogs with confirmed gastric tumors. For each included dog, the following CT parameters were recorded: gastric tumor location, tumor shape, gastric involvement pattern, tumor enhancement pattern in early and late phases, presence and location of lymphadenopathy, gastric tumor attenuation values, attenuation values of enlarged lymph nodes, maximum short-axis diameter (mm) of enlarged lymph node, maximum long-axis diameter (mm) of enlarged lymph node, and short-axis diameter to long-axis diameter ratio (short axis/long axis). A total of 16 dogs met inclusion criteria and had the following final diagnoses: five lymphoma, six adenocarcinoma, three inflammatory polyps, and two leiomyoma. In the early- and delayed-phase postcontrast images, the mean CT attenuation value for lymphoma was lower than that of other gastric tumors. Lymphadenopathy was widespread in lymphomas and regional in adenocarcinomas. Lymphadenopathy was not detected in leiomyomas. Lymph node measurements in lymphoma were larger than lymph node measurements in adenocarcinoma. Although there were overlapping findings for the different types of gastric tumors, contrast-enhanced CT provided helpful information for characterizing gastric tumors based on the following criteria: early and late enhancement patterns, the site of origin of the mass lesion, and extent of local invasion and distant metastases. Lymphoma should be considered for canine gastric tumors with low mean attenuation values during early- and delayed-phase postcontrast images, and widespread, bulky, and rounded lymphadenopathy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Contrast‐enhanced computed tomography may be helpful for characterizing and staging canine gastric tumors

Tanaka

Akiyoshi

Mie

et al. 2018

Vet Radiology Ultrasound

View full text Add to dashboard Cite

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“…An assessment of the minimum surgical margin distance necessary to achieve histologically complete margins for canine gastric carcinoma could not be determined from our data. Current margin recommendations for wide excision of gastric neoplasia in dogs are 1–2 cm of apparently normal tissue around the tumor . However, to the best of the authors' knowledge, true surgical safety margins have not been evaluated for canine gastric neoplasia.…”

Section: Discussionmentioning

confidence: 99%

“…This finding suggests that the prescribed 1–2‐cm margins may not be adequate. In humans with gastric carcinoma, surgical margins have a significant effect on patient survival, and recommendations are dependent on the histologic subtype . For the diffuse type of gastric carcinoma, recommended margins are greater than 5 cm, and, for the intestinal type, 2–3 cm is suggested …”

Section: Discussionmentioning

confidence: 99%

Perioperative complications and outcome after surgery for treatment of gastric carcinoma in dogs: A Veterinary Society of Surgical Oncology retrospective study of 40 cases (2004–2018)

et al. 2019

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Objective: To describe the clinical characteristics, perioperative complications, and outcomes in dogs surgically treated for gastric carcinoma. Study design: Multi-institutional retrospective case series. Animals: Forty client-owned dogs with histologically confirmed gastric carcinoma.Methods: Medical records were reviewed for preoperative diagnostics, surgery, histopathology, postoperative complications, adjuvant chemotherapy, disease progression, and survival. Variables were assessed for associations with outcome by using Cox proportional hazards regression analysis. Results: Surgical treatment included partial gastrectomy (28 dogs), Billroth I (9 dogs), subtotal gastrectomy (2 dogs), and submucosal resection (1 dog). Major postoperative complications occurred in 8 of 40 dogs, including septic peritonitis secondary to dehiscence in 4 dogs. The median progression free interval was 54 days, and the median survival time (MST) was 178 days (range, 1-1902). According to multivariable analysis results, experiencing an intraoperative complication was associated with an increased risk of death (hazard ratio [HR] 3.5, 95% CI 1.1-9.8, P = .005), and administration of adjuvant chemotherapy correlated with an improved survival (HR 0.4, 95% CI 0.2-0.9, P = .03). Conclusion: In this population of dogs, MST exceeded historically reported data, major postoperative complication rates were comparable to established literature, and administration of adjuvant chemotherapy was associated with improved survival.

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“…Gastrointestinal disturbance in dog can be upper digestive tract disorders. Such cases in dog usually involves esophagus (Tarvin et al, 2016), stomach (Hugen et al, 2016), and proximal duodenum (Ruiz et al, 2016). Diagnoses of the disturbance can be done through several steps such as anamneses, signs and physical examination.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Imaging and Endoscopy of the Schnauzer Dog With Upper Gastrointestinal Tract Disorders

et al. 2017

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The aim of this study was to describe the role of diagnostic imaging and endoscopy to define the diagnose of the upper gastrointestinal tract disorder of the Schnauzer. The information from the owner stated that the dog has been vomiting for a year, sometimes containing blood. There might also be a possibility that it had eaten a corpus alienum. This case study covered physical examination, hematology and blood chemical analysis, diagnostic imaging radiography and ultrasonography as well as endoscopy performed. Physical examination showed weight loss and anorexia. Hematology and blood chemical analysis showed an increase in hemoglobin, hematocrit, lymphocyte, ureum, creatinine, alanine aminotransferase (ALT), and alkaline phosphatase (ALP) values. Abdominal radiograph showed no abnormality in the abdominal organs. Abdominal ultrasonography showed a hiperechoic elongated mass attached on the stomach mucosal surface which forms an acoustic shadowing at the ventral. Endoscopy showed pathological lesions that is inconsistency of stomach mucosa surface, foamy fluid in the stomach, ulcers and erosion of the stomach mucosal surface. Based on the diagnostic imaging and endoscopy performed, the animal was clearly diagnosed with chronic gastritis accompanied by stomach ulcer and erosion. ____________________________________________________________________________________________________________________ Key words: diagnostic imaging, endoscopy, Schnauzer, upper gastrointestinal tract disorder ABSTRAK Studi kasus ini bertujuan menetapkan diagnosis gangguan saluran pencernaan atas pada anjing Schnauzer melalui pencitraan and endoskopi. Berdasarkan keterangan dari pemilik (anamnesa), anjing mengalami muntah yang intermiten and sesekali disertai darah yang sudah berlangsung selama satu tahun serta diduga anjing tersebut memakan benda asing. Studi kasus yang dilakukan meliputi pemeriksaan fisik, pemeriksaan hematologi and kimia darah, pencitraan radiografi, pencitraan ultrasonografi, serta endoskopi. Hasil pemeriksaan fisik menunjukkan aandya kondisi kekurusan and anoreksia. Pemeriksaan hematologi and kimia darah menunjukkan aandya peningkatan jumlah limfosit, hemoglobin (Hb), hematokrit (Hct), ureum, kreatinin, alanine aminotransferase (ALT), and alkaline phosphatase (ALP). Pencitraan radiografi abdomen menunjukkan tidak terdapat kelainan pada organ-organ di daerah abdomen. Ultrasonografi lambung terlihat bentukan hiperekhoik memanjang pada permukaan mukosa lambung yang membentuk acoustic shadowing di bagian ventral namun temuan ini tidak spesifik terhadap satu kelainan tertentu. Hasil endoskopi menunjukkan beberapa lesio patologis yang sangat siginifkan yaitu ketidakteraturan mukosa lambung, busa cairan empedu di lambung, ulkus, and erosi lambung. Berdasarkan gabungan hasil diagnosis pencitraan and endoskopi, hewan didiagnosis menderita gastritis kronis disertai ulkus and erosi lambung. ____________________________________________________________________________________________________________________ Kata kunci: diagnosis pen...

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Gastric carcinoma in canines and humans, a review

Cited by 34 publications

References 114 publications

Contrast‐enhanced computed tomography may be helpful for characterizing and staging canine gastric tumors

Contrast‐enhanced computed tomography may be helpful for characterizing and staging canine gastric tumors

Perioperative complications and outcome after surgery for treatment of gastric carcinoma in dogs: A Veterinary Society of Surgical Oncology retrospective study of 40 cases (2004–2018)

Diagnostic Imaging and Endoscopy of the Schnauzer Dog With Upper Gastrointestinal Tract Disorders

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