Gastric carcinoma with argyrophilic cells: Light microscopic, electron microscopic, and immunochemical study

Prade, M; Bara, Jacques; Gadenne, C; Bognel, C; Charpentier, P; Ravazzola, Mariella; Caillou, Bernard

doi:10.1016/s0046-8177(82)80277-3

Cited by 20 publications

(6 citation statements)

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“…Previously, two cases of gastric cancer with neuroendocrine differentiation in neutral and acid mucin-negative signet ring cells have been reported (Morii et al 1999;Sugihara et al 2004), and a few case reports have described mucin-positive gastric signet ring cells with neuroendocrine markers (Tahara et al 1975;Prade et al 1982).…”

Section: Discussionmentioning

confidence: 99%

“…This study demonstrates that in 8/11 diffuse gastric cancers with signet ring cells, a proportion of PAS-positive signet ring cells express one or more neuroendocrine markers, a finding previously reported to be rare. Previously, two cases of gastric cancer with neuroendocrine differentiation in neutral and acid mucin-negative signet ring cells have been reported (Morii et al 1999; Sugihara et al 2004), and a few case reports have described mucin-positive gastric signet ring cells with neuroendocrine markers (Tahara et al 1975; Prade et al 1982).…”

Section: Discussionmentioning

confidence: 99%

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Signet Ring Cells in Gastric Carcinomas Are Derived from Neuroendocrine Cells

Bakkelund

Fossmark

Nordrum

et al. 2006

J Histochem Cytochem.

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S U M M A R Y Adenocarcinomas are malignant tumors with glandular growth and/or supposed intracellular mucin as identified by periodic acid-Schiff (PAS) positivity. Gastric signet ring cell carcinomas are classified as diffuse type. A proportion of diffuse-type adenocarcinomas have previously been suggested to be of neuroendocrine origin. In the present study we examined gastric signet ring cell carcinomas for neuroendocrine differentiation. Of 11 gastric signet ring cell carcinomas, 8 contained areas with PAS-positive signet ring cells that also were immunoreactive for one or several neuroendocrine markers: synaptophysin, chromogranin A, and histidine decarboxylase, the latter an enterochromaffin-like (ECL) cell marker. Whereas PAS positivity was located in the central cytoplasm, neuroendocrine immunoreactivity was often located as a rim surrounding an otherwise nonimmunoreactive cytoplasm, presumed to represent the area with PAS-positive material. These findings indicate that signet ring cell carcinomas could be of neuroendocrine origin. We propose that signet ring cell carcinomas develop by gradual dedifferentiation from ECL cells via signet ring cells with neuroendocrine immunoreactivity toward signet ring cells where the cytoplasm mainly consists of PAS-positive material. This finding could have implications for the classification and understanding of gastric carcinogenesis. (J Histochem Cytochem 54:615-621, 2006)

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Signet Ring Cells in Gastric Carcinomas Are Derived from Neuroendocrine Cells

Bakkelund

Fossmark

Nordrum

et al. 2006

J Histochem Cytochem.

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“…In many tumours classified as adenocarcinomas based upon a glandular growth pattern and/or tumour cells positive for PAS or Alcian blue and thus believed to contain mucin, there are tumour cells with neuroendocrine properties [ 12 ]. These neuroendocrine cells are believed to be redifferentiated exocrine derived tumour cells [ 6 , 7 ].…”

Section: Neuroendocrine Tumoursmentioning

confidence: 99%

Classification of tumours

Waldum

Sandvik

Brenna

et al. 2008

J Exp Clin Cancer Res

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Tumours are classified according to the most differentiated cells with the exception of carcinomas where a few tumour cells show neuroendocrine differentiation. In this case these cells are regarded as redifferentiated tumour cells, and the tumour is not classified as neuroendocrine. However, it is now clear that normal neuroendocrine cells can divide, and that continuous stimulation of such cells results in tumour formation, which during time becomes increasingly malignant. To understand tumourigenesis, it is of utmost importance to recognize the cell of origin of the tumour since knowledge of the growth regulation of that cell may give information about development and thus possible prevention and prophylaxis of the tumour. It may also have implications for the treatment. The successful treatment of gastrointestinal stromal tumours by a tyrosine kinase inhibitor is an example of the importance of a correct cellular classification of a tumour. In the future tumours should not just be classified as for instance adenocarcinomas of an organ, but more precisely as a carcinoma originating from a certain cell type of that organ.

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“…11,13 This may be due to the lack of subtyping of underlying adenocarcinomas with NE differentiation. Although several reports have referred to such differentiation in SRCCs as one type of general adenocarcinoma, [10][11][12][18][19][20][21] most have not focused specifically on SRCC.…”

Section: Introductionmentioning

confidence: 99%