Gastric Changes in Pernicious Anemia—a Review

MOLOFSKY, LEONARD C.

doi:10.1001/archinte.1951.03810010107008

Cited by 8 publications

(1 citation statement)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The classic hematological manifestation of AIG is vitamin B12 (pernicious) anemia due to the lack of intrinsic factor. However, as achlorhydria may antedate pernicious anemia by as long as 35 years, B12 deficiency is typically a late finding in AIG patients [12]. Iron deficiency is the most frequent hematological manifestation [13] and the prevalence of iron and B12 deficiency in AIG patients are estimated to be 50% and 37–60% respectively [14].…”

Section: Introductionmentioning

confidence: 99%

Management of upper gastrointestinal symptoms in patients with autoimmune gastritis

Cifuentes

Sparkman

Graham

2022

Current Opinion in Gastroenterology

View full text Add to dashboard Cite

Purpose of reviewAutoimmune gastritis is characterized by atrophy of acid secreting parietal cells resulting in achlorhydria. Upper gastrointestinal symptoms are common in autoimmune gastritis and frequently result in prescriptions for acid suppressant medications despite the inability of the stomach to secrete acid. Evidence-based recommendations for management of gastrointestinal symptoms in autoimmune gastritis are lacking. Recent findingsThe most common symptoms in patients with autoimmune gastritis are dyspepsia, heartburn, and regurgitation. Gastroesophageal reflux should be confirmed by pH-impedance testing and is typically weakly acid or alkaline. Therapy for reflux focuses on mechanical prevention of reflux (i.e., elevation of the head of the bed and alginates) or when severe, antireflux surgery. The etiology of dyspepsia in autoimmune gastritis is unclear and largely unstudied. In the first half of the 20th century, oral administration of acid to ''aid digestion'' was widely used with reported success. However, randomized, placebo-controlled trials are lacking. Here, we provide suggestions for attempting gastric acidification therapy. SummaryUpper GI symptoms are common in autoimmune gastritis. Their pathogenesis and therapy remain incompletely understood. Acid suppressant medications are useless and should be discontinued. A trial of acid replacement therapy is recommended especially in the form of placebo-controlled trials.

show abstract

Section: Introductionmentioning

confidence: 99%