Gastric clearance of serum albumin in normal man and in certain gastroduodenal disorders

Abstract

SUMMARY Serum albumin gastric loss was estimated from the measurement of non-dialysable radioactivity of the gastric juice after intravenous injection of radioiodinated serum albumin (RISA). Immunochemical quantitation of serum albumin was performed in some of the samples.In the control group, the mean gastric clearance of albumin was 1.71 ml per hour with a range of 0.41 to 4.41 ml per hour. This represented a gastric loss of 1.9 gram of albumin per day and 11 % of the daily degradation of albumin. There was no significant change in the gastric albumin loss after stimulating the gastric secretion. No significant difference in the gastric albumin leakage was found between normal subjects and patients with gastric or duodenal ulcer.In pernicious anaemia albumin loss into the stomach was greater (mean: 3-72 ml per hour; SD 1.52 ml) than in the normal group and accounted for the greater albumin fractional catabolic rate. This fact had never been proved before. In both patients with giant rugae of the gastric mucosa the gastric clearance of serum albumin was also increased.It is concluded first that albumin is not secreted by the chief and parietal cells of the mucosa and probably passes through the gastric wall between the cells of the mucosa, perhaps during the exfoliation of the surface epithelial cells, and secondly that the stomach is one of the sites of serum albumin breakdown, a fact that supports the view that the gastrointestinal tract plays a major role in the catabolism of serum albumin.

Gastrointestinal Endogenous Proteins as a Source of Bioactive Peptides - An In Silico Study

“…Not all gut endogenous proteins are secreted ubiquitously throughout the gastrointestinal tract [25] . For example while serum albumin is known to be secreted into both the stomach and the small intestine [39] , [40] , trypsin is only secreted into the duodenum and therefore is only subject to digestion in the small intestine. For proteins that are secreted in the small intestine, digestion in the gastrointestinal tract was predicted based on an in silico model for small intestinal digestion alone with the two major intestinal enzymes trypsin and chymotrypsin.…”

Chemotactic response of Helicobacter pylori to human plasma and bile

“…The leakage or transudation of plasma from microcapillaries into interstitial spaces, and then into the lumen of the stomach, is a normal occurrence (Brassinne, 1979;Hollander & Horowitz, 1962), and is increased considerably when gastric mucosa is damaged experimentally (Brassinne, 1979;Sober et al, 1950) or through disease (Brassinne, 1974;Jarnum & Jensen, 1972). Thus, H. pylori colonizing the gastric microenvironment will be exposed to plasma, and Abbreviations: CLV, curvilinear velocity; CR, chemotactic response.…”