Gastric collision between a papillotubular adenocarcinoma and a gastrinoma in a patient with Zollinger-Ellison syndrome

Leval, Laurence de; Hardy, N; Deprez, Manuel; Delwaide, Jean; Bélaïche, Jacques; Boniver, Jacques

doi:10.1007/s00428-002-0707-9

Cited by 13 publications

(16 citation statements)

References 11 publications

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“…The mean age of the patients was 61 years (47–84). The majority were nonfunctional carcinoids while large cell endocrine carcinoma [10] and gastrinomas [11, 12] have also been described. The latter were discovered during investigation for Zollinger-Ellison syndrome.…”

Section: Methodsmentioning

confidence: 99%

“…de Leval et al [11] described a case of collision of a gastrin-producing carcinoid and a gastric adenocarcinoma. They stated that gastrin's trophic effect on gastric mucosa could induce gastric adenocarcinoma development.…”

Section: Methodsmentioning

confidence: 99%

“…MEECs can be categorized into four categories according to their morphological features: carcinomas with interspersed endocrine cells, carcinoids with interspersed nonendocrine cells, amphicrine tumors, and mixed tumors [34]. Mixed tumors can be classified into composite tumors, where histological components are distinct but admixed and present areas of histological transition and collision tumors, where histological components are not admixed and present a clear-cut margin between them [11, 21, 35]. …”

Section: Methodsmentioning

confidence: 99%

“…Additional findings relevant to tumor type are rarely present. Yoshino et al and de Leval et al diagnosed such a tumor from high gastrin levels, while Komatsu et al suspected such a tumor from high G-SF production [11, 27, 37]. Apart from these 2 reports no other specific findings have been described elsewhere.…”

Section: Methodsmentioning

confidence: 99%

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Gastric Collision Tumors: An Insight into Their Origin and Clinical Significance

Michalinos

Constantinidou

Kontos

2015

Gastroenterology Research and Practice

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Collision tumors are rare neoplasms displaying two distinct cell populations developing in juxtaposition to one another without areas of intermingling. They are rare entities with only 63 cases described in English literature. Tumors encountered are gastric adenocarcinomas colliding with lymphomas, gastrointestinal stromal tumors, squamous cell carcinomas, and neuroendocrine tumors. Their cell origin is obsolete by the time of diagnosis. Different tumorigenesis theories have been suggested to explain their behavior, yet none has managed to provide satisfactory explanation for all cases. Clinically they are indistinguishable from the dominant tumor. Lack of data does not allow detailed assessment of their behavior yet they seem aggressive neoplasms with dismal prognosis. The majority of cases have been diagnosed postoperatively during histologic examination of specimens. There are no guidelines or concrete evidence to support best way of adjuvant or other types of treatment. However, these rare neoplasms might help in unlocking secrets of cancer behavior including tumorigenesis, differentiation, and adhesion and thus clinicians should be aware of their existence.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Gastric Collision Tumors: An Insight into Their Origin and Clinical Significance

Michalinos

Constantinidou

Kontos

2015

Gastroenterology Research and Practice

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“…18 The collision of carcinomas with carcinoid tumors has also been reported frequently, and it has been suggested that carcinoids can produce substances with a growth promoting effect accounting for the occurrence of a second tumor in the vicinity. 3 However, many collision tumors have no explanation for their occurrence, and as most diagnoses have been made on histology alone, the question exists as to whether histologic classifications accurately reflect the molecular findings in these tumors. Genetic analysis would provide evidence regarding whether the tumors originate from the same or different clones.…”

mentioning

confidence: 99%

Do Collision Tumors of the Gastroesophageal Junction Exist?

Milne¹,

Carvalho²,

Rees³

et al. 2004

American Journal of Surgical Pathology

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Collision tumors are thought to arise from the accidental meeting of two independent tumors. Here we present five gastroesophageal junction tumors consisting of two collision tumors and three composite tumors (characterized by two divergent lineages originating from the same neoplastic clonal proliferation), as diagnosed on histology. In an attempt to prove this distinction at a genetic level, we performed TP53 sequence analysis and p53 immunohistochemistry. In addition, loss of heterozygosity (LOH) analysis using 10 microsatellite markers was carried out. An identical TP53 mutation and a similar pattern of retention and LOH were found in both neoplastic components of the presumed collision tumors, suggesting that both components are derived from a single precursor cell that undergoes divergent differentiation in the evolution of the tumor. In the composite group, 1 case had a genetic basis for the possible diagnosis of a collision tumor, with a TP53 mutation in the adenocarcinoma component only, and a different pattern of retention and loss of heterozygosity. These findings imply that it is not possible to recognize true collision tumors from immunohistologic appearance alone and suggest that the long-standing histologic criteria for the diagnosis of these neoplasms have no molecular basis.

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Successful surgery with preservation of laryngeal function in a patient with collision primary squamous cell carcinoma and adenoid cystic carcinoma in the hypopharynx and synchronous esophageal carcinoma: A case report

Fu,

Xu,

Bao

et al. 2023

Head & Neck

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BackgroundThe definition of “collision tumor” is the coexistence of two histologically and morphologically distinct tumors within the same anatomical area without histological admixture. Collision tumors featuring primary squamous cell and adenoid cystic carcinomas of the hypopharynx, combined with synchronous esophageal carcinoma, are very rare.MethodsWe describe a patient with a collision tumor of the hypopharynx and synchronous esophageal carcinoma who underwent partial laryngectomy, with preservation of laryngeal function, and radical esophageal resection featuring esophageal reconstruction using a gastric tube. Surgery was successful.ResultsPostoperative radiotherapy was recommended after surgery; the patient exhibited no recurrence or distant metastasis to the 17‐month follow‐up.ConclusionTo the best of our knowledge, this is the first report of collision of primary squamous cell carcinoma and adenoid cystic carcinoma in the hypopharynx and synchronous esophageal carcinoma. We performed appropriate surgery and prescribed postoperative radiotherapy. This preserved laryngeal function.

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Gastric collision between a papillotubular adenocarcinoma and a gastrinoma in a patient with Zollinger-Ellison syndrome

Cited by 13 publications

References 11 publications

Gastric Collision Tumors: An Insight into Their Origin and Clinical Significance

Gastric Collision Tumors: An Insight into Their Origin and Clinical Significance

Do Collision Tumors of the Gastroesophageal Junction Exist?

Successful surgery with preservation of laryngeal function in a patient with collision primary squamous cell carcinoma and adenoid cystic carcinoma in the hypopharynx and synchronous esophageal carcinoma: A case report

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