Gastric compliance in bulimia nervosa

Zimmerli, Ellen; Walsh, B. Timothy; Guss, Janet L.; Devlin, Michael J.; Kissileff, Harry R.

doi:10.1016/j.physbeh.2005.11.010

Cited by 30 publications

(29 citation statements)

References 40 publications

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“…Second, Kissileff et al, (1996) reported that bulimic participants needed to eat significantly more food (around 60%) to obtain similar levels of fullness as compared to healthy controls (r ¼ 0.65 [n ¼ 20]). While these studies suggest impaired interoception in bulimia nervosa, one further study failed to find any difference in gastric compliance and sensory response to fullness (Zimmerli, Walsh, Guss, Devlin, & Kissileff, 2006). This may have resulted from differences in the sensitivity of the method used to assess stomach volume.…”

Section: Psychiatric Conditions and Individual Differences In Interocmentioning

confidence: 95%

Individual differences in the interoceptive states of hunger, fullness and thirst

2015

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Section: Psychiatric Conditions and Individual Differences In Interocmentioning

confidence: 95%

Individual differences in the interoceptive states of hunger, fullness and thirst

2015

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“…Eating large amounts of food on a daily basis and the loss of food through postprandial vomiting interfere with satiety signals (Zimmerli et al 2006). Instead of regular meals during daytime, efforts at avoiding food at all costs, punctuated by nocturnal eating binges followed by vomiting, produce an unpredictable and chaotic eating pattern.…”

Section: Animal Models Of Anmentioning

confidence: 99%

Relevance of animal models to human eating disorders and obesity

2008

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Background and rationale This review addresses the role animal models play in contributing to our knowledge about the eating disorders anorexia nervosa (AN) and bulimia nervosa (BN) and obesity. Objectives Explore the usefulness of animal models in complex biobehavioral familial conditions, such as AN, BN, and obesity, that involve interactions among genetic, physiologic, psychological, and cultural factors. Results and conclusionsThe most promising animal model to mimic AN is the activity-based anorexia rodent model leading to pathological weight loss. The paradigm incorporates reward elements of the drive for activity in the presence of an appetite and allows the use of genetically modified animals. For BN, the sham-feeding preparation in rodents equipped with a gastric fistula appears to be best suited to reproduce the postprandial emesis and the defects in satiety. Animal models that incorporate genes linked to behavior and mood may clarify biobehavioral processes underlying AN and BN. By contrast, a relative abundance of animal models has contributed to our understanding of human obesity. Both environmental and genetic determinants of obesity have been modeled in rodents. Here, we consider single gene mutant obesity models, along with models of obesigenic environmental conditions. The contributions of animal models to obesity research are illustrated by their utility for identifying genes linked to human obesity, for elucidating the pathways that regulate body weight and for the identification of potential therapeutic targets. The utility of these models may be further improved by exploring the impact of experimental manipulations on the behavioral determinants of energy balance.

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“…The findings of slowed gastric emptying and of impaired gastric ac-commodation following food ingestion indicate that stomach function in BN is characterized by a reduction in meal-related gastric muscular activity. These results suggest that, in patients with BN, the stomach might also be more easily distensible, perhaps as a result of repeated episodes of binge eating [5].…”

Section: Discussionmentioning

confidence: 81%

“…Nevertheless, although not all studies have demonstrated statistical differences in gastric compliance with controls, it has been well established that patients with BN exhibit diminished sensitivity to gastric distention [5].…”

Section: Dysregulation Of Cck In Bulimia Nervosamentioning

confidence: 98%

“…BN, one of the most common and secretive of these disorders, is characterized by compulsive binge eating followed by compensatory efforts, usually vomiting or laxative abuse, in order to purge calories and avoid weight gain [4,5]. This disorder is usually a chronic illness, which has been related to physiological disturbances in many neuronal and endocrine systems, especially the satiety reflex.…”

Section: Introductionmentioning

confidence: 99%

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