Gastric emptying and morphology of a ‘near real’ in vitro human stomach model (RD-IV-HSM)

Chen, Liding; Xu, Yufen; Fan, Tingting; Liao, Zhenkai; Wu, Peng; Wu, Xuee; Chen, Xiao

doi:10.1016/j.jfoodeng.2016.02.025

Cited by 66 publications

(26 citation statements)

References 36 publications

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“…In this case, it is a good entry point for getting involved in the bio‐inspired chemical engineering, working on the understanding of the physiology of animal and human digestion. We have constructed uniquely the near‐real in vitro stomach systems for rats and humans . An interesting intestinal bench‐scale silicone tubular reactor was constructed and investigated for residence time distribution and, most recently, a process for hydrolysis of the very viscous solution of starch was demonstrated with the intestinal reactor .…”

Section: Introductionmentioning

confidence: 99%

A Soft‐Elastic Reactor Inspired by the Animal Upper Digestion Tract

2018

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A soft‐elastic reactor is described, which was inspired by the animal upper digestion tract. The mixing is triggered by wall movements. Silicone material was selected based on previous experiences and conditioned into a standard cylindrical shape. Mixing was induced by the wall deformation triggered by the peristaltic movement, i.e., periodic protrusion towards the wall. Viscous glycerin solution served as sample material and a tracer was added to visualize the mechanisms of mixing. The fluid motion initiated by the soft‐elastic wall movement could be an interesting alternative to stirrer agitation. Pros and Cons are briefly highlighted. Due to the abundance of industrial soft‐elastic materials such as silicone, it is expected that, inspired by the soft reactors, a series of inventions in chemical reactor engineering will be offered in the near future.

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Section: Introductionmentioning

confidence: 99%

A Soft‐Elastic Reactor Inspired by the Animal Upper Digestion Tract

2018

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“…The in vitro dynamic digestion model (a ‘near real’ in vitro human stomach model, RD‐IV‐HSM; Chen et al ., ) was developed and provided by Xiao Dong Pro‐health Instrumentation Co. Ltd. (Suzhou, China). Liquid silicone was used to form a ‘J’ shape of simulated human stomach model, and the model had wrinkles on its inner‐surface.…”

Section: Methodsmentioning

confidence: 99%

Effects of simulated gastric and intestinal digestion on chitooligosaccharides in two in vitro models

Chen

Xie

et al. 2019

Int J of Food Sci Tech

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Chitooligosaccharides (COS) with different degree of polymerisation (DP) have different physiological activities such as anti-tumour and anti-hyperlipidemia activities. However, the digestive process might lead to the change of DP of COS as well as cause the change of physiological activities in vivo. In this study, two in vitro digestion models (static and dynamic) were used to investigate digestion behaviours of COS and the influencing factors during digestion with or without food matrix. The results showed that COS with DP 2-5 were indigestible and COS with DP 6-10 degraded with time during gastric and intestinal digestion. Pepsin, pancreatin and lipase were the main factors leading to degradation. Food matrix could protect COS with DP 6-10 from degradation during gastric digestion. However, the degradation of COS with DP 6-10 accelerated and the degradation of COS with DP 5 occurred during intestinal digestion with food matrix due to pancreatin, lipase and bile salt. Keywords Chitooligosaccharides, degree of polymerisation, digestive behaviour, in vitro dynamic digestion model, in vitro static digestion model. The digestion of chitooligosaccharides J. Chen et al.

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“…Chen and colleagues [108] developed a novel in vitro model with special focus on the anatomical appearance of the stomach (Figure 13). With the use of three strings they were able to generate local contractions to mimic the antral region [108]. The dimensions and also the gastric rugae were correctly simulated using an actual human stomach as a template [108].…”

Section: Characterization Of Gastroretentive Dosage Formsmentioning

confidence: 99%

“…With the use of three strings they were able to generate local contractions to mimic the antral region [108]. The dimensions and also the gastric rugae were correctly simulated using an actual human stomach as a template [108]. Although this device was designed for the simulation of digestive processes, the model can potentially be used for the investigation of gastroretentive systems.…”

Section: Characterization Of Gastroretentive Dosage Formsmentioning

confidence: 99%

In Vitro and In Vivo Test Methods for the Evaluation of Gastroretentive Dosage Forms

Schneider

Koziolek

2019

Pharmaceutics

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More than 50 years ago, the first concepts for gastroretentive drug delivery systems were developed. Despite extensive research in this field, there is no single formulation concept for which reliable gastroretention has been demonstrated under different prandial conditions. Thus, gastroretention remains the holy grail of oral drug delivery. One of the major reasons for the various setbacks in this field is the lack of predictive in vitro and in vivo test methods used during preclinical development. In most cases, human gastrointestinal physiology is not properly considered, which leads to the application of inappropriate in vitro and animal models. Moreover, conditions in the stomach are often not fully understood. Important aspects such as the kinetics of fluid volumes, gastric pH or mechanical stresses have to be considered in a realistic manner, otherwise, the gastroretentive potential as well as drug release of novel formulations cannot be assessed correctly in preclinical studies. This review, therefore, highlights the most important aspects of human gastrointestinal physiology and discusses their potential implications for the evaluation of gastroretentive drug delivery systems.

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Gastric emptying and morphology of a ‘near real’ in vitro human stomach model (RD-IV-HSM)

Cited by 66 publications

References 36 publications

A Soft‐Elastic Reactor Inspired by the Animal Upper Digestion Tract

A Soft‐Elastic Reactor Inspired by the Animal Upper Digestion Tract

Effects of simulated gastric and intestinal digestion on chitooligosaccharides in two in vitro models

In Vitro and In Vivo Test Methods for the Evaluation of Gastroretentive Dosage Forms

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