Gastric emptying disorder in children and adolescents with diabetes mellitus type 1

Update on pediatric gastroparesis: A review of the published literature and recommendations for future research

“…One study found statistically significant delayed gastric emptying in patients with portal hypertension compared to healthy controls, postulating that delayed gastric emptying can lead to or aggravate portal hypertensive gastropathy . Patients with diabetes mellitus type I, Turner's syndrome, pancreatic insufficiency, and cystic fibrosis have a higher prevalence of gastroparesis than the standard population . While up to 38% of patients with cystic fibrosis may have gastroparesis, small studies suggest that younger patients with untreated pancreatic insufficiency actually have rapid gastric emptying .…”

“…40 Patients with diabetes mellitus type I, Turner's syndrome, pancreatic insufficiency, and cystic fibrosis have a higher prevalence of gastroparesis than the standard population. [41][42][43][44][45][46][47][48][49] While up to 38% of patients with cystic fibrosis may have gastroparesis, small studies suggest that younger patients with untreated pancreatic insufficiency actually have rapid gastric emptying. 50 The significance of objectively measured delayed gastric emptying and its relation to symptoms in these populations remain unclear and require further prospective studies.…”

“…While the etiology of gastroparesis has been studied extensively in adults, there are few pediatric studies and underlying mecha- Inflammatory processes and chronic illness 35,38,[40][41][42][43][44][45][46][47][48][49][50] Connective tissue disorders and dystrophies [22][23][24][25][26][27][28][29] Anatomical abnormalities [98][99][100][101][102][103][104]192 • Epstein-Barr Virus Trauma and critical care [32][33][34] Nutritional Intake pathophysiology is further compounded by its multifactorial nature.…”