Gastric emptying in patients with gastroesophageal reflux

Gastric Electrical Stimulation Significantly Increases Canine Lower Esophageal Sphincter Pressure

“…delayed emptying tend to have longer esophageal acid exposure than those with normal emptying (6)(7)(8). The reasons for the latter findings are not altogether clear (9,10).…”

Esophageal motility in Japanese patients with Barrett?s esophagus

“…In consideration of these findings, it is suggested that BE represents an advanced stage of severe RE, and the results show that esophageal motility in Japanese patients with BE is similar to that in BE patients in Western countries. [10][11][12][13] There is continuing controversy as to whether RE causes esophageal dysmotility. [25][26][27] However, at 18 cm above the LES, where exposure to acid reflux fluid is rare, there was no difference in esophageal wave amplitudes between any of our groups, and the esophageal dysmotility gradually worsened as the RE became more severe.…”

“…9 With regard to the induction of GERD, as well as BE, gastric acid is the major offender and is primarily responsible for the esophageal mucosal damage in reflux disease. The mechanisms involved in GERD are mainly based on disturbance of upper gastrointestinal motility, impaired basal tone of the lower esophageal sphincter (LES), higher frequency of spontaneous relaxations of the LES, prolonged gastric emptying time, 10,11 and impaired esophageal peristalsis. 11 With regard to motility in patients with BE, these patients usually have low basal LES pressures.…”

Impaired gastric motility and its relationship to reflux symptoms in patients with nonerosive gastroesophageal reflux disease

“…Several previous studies [10][11][12][13][14] have demonstrated that gastric emptying of both solid meals and liquids is delayed in patients with GERD. However, most of these studies did not distinguish patients with endoscopic esophagitis from those with NERD, and it is not clear whether the patients had mucosal breaks.…”