Gastric Emptying is Delayed in Transgastric Notes: A Randomized Study in Swine

Córdova, Henry; Guarner-Argente, Carlos; Martínez-Pallí, Graciela; Navarro, Ricard; Rodríguez-D’Jesús, Antonio; Miguel, Cristina Rodríguez de; Beltrán, Mireia; Martínez-Zamora, M. Àngels; Comas, Jaume; Lacy, Antonio M.; Thompson, Christopher C.; Fernández‐Esparrach, Glòria

doi:10.1016/j.jss.2011.10.034

Cited by 7 publications

(5 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the recent years there has been increasing interest in natural orifice transluminal endoscopic surgery (NOTES), a concept which was first described in 2004 [1]. The randomized controlled study by Cordova et al first referred to the transvaginal NOTES access as vNOTES [2]. Hysterectomy was the first gynaecological procedure performed as vNOTES in 2012 [3].…”

Section: Introductionmentioning

confidence: 99%

Consensus on safe implementation of vaginal natural orifice transluminal endoscopic surgery (vNOTES)

Kapurubandara

Löwenstein

Salvay³

et al. 2021

European Journal of Obstetrics & Gynecology and Reproductiv

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Consensus on safe implementation of vaginal natural orifice transluminal endoscopic surgery (vNOTES)

Kapurubandara

Löwenstein

Salvay³

et al. 2021

European Journal of Obstetrics & Gynecology and Reproductiv

View full text Add to dashboard Cite

“…After the evolution from laparotomy to laparoscopy, this evolution was continued with single‐site surgery (single‐incision laparoscopic surgery or laparo‐endoscopic single‐site surgery) and natural orifice transluminal endoscopic surgery (NOTES) with or without robotic assistance. Different natural orifices can be used to perform NOTES: transvaginal, transgastric , transrectal and transurethral 1 …”

Section: Introductionmentioning

confidence: 99%

“…Different natural orifices can be used to perform NOTES: transvaginal, transgastric , transrectal and transurethral. 1 Vaginal Natural Orifice Transluminal Endoscopic Surgery (vNOTES) enables surgeons to perform minimally invasive abdominal and pelvic surgery through a colpotomy without making any abdominal incisions. In 2018 our group published the results of a first randomised controlled trial (HALON trial) comparing vNOTES with laparoscopy for hysterectomy.…”

Section: Introductionmentioning

confidence: 99%

Adnexectomy by vaginal Natural Orifice Transluminal Endoscopic Surgery versus laparoscopy: results of a first randomised controlled trial (NOTABLE trial)

Baekelandt

Mulder

Roy

et al. 2021

BJOG

View full text Add to dashboard Cite

Objective To compare adnexectomy by vaginal Natural Orifice Transluminal Endoscopic Surgery (vNOTES) versus laparoscopy. Design Parallel group, 1:1 single‐centre single‐blinded randomised trial, designed as non‐inferiority study with a margin of 15%. Setting Belgian teaching hospital. Population Non‐pregnant non‐virgin women with an intact uterus and without obliteration of the pouch of Douglas scheduled to undergo removal of an adnexal mass assessed to be benign on ultrasound by IOTA criteria. Methods Randomisation to laparoscopy (control group) or vNOTES (experimental group). Stratification according to adnexal size. Blinding of participants and outcome assessors by sham incisions. Main outcome measures The primary outcome measure was adnexectomy by the allocated technique. Secondary outcomes included duration of surgery, pain scores and analgesics used, quality of life and adverse events. Results We randomly assigned 67 participants (34 to the vNOTES group and 33 to the laparoscopy group). The primary end point was always reached in both groups: there were no conversions. We performed a sensitivity analysis for the primary outcome, assuming one conversion in the vNOTES group and no conversions in the laparoscopy group: the one‐sided 95% upper limit for the differences in proportions of conversion was estimated as 13%, which is below the predefined non‐inferiority margin of 15%. The secondary outcomes demonstrated a shorter duration of surgery, lower pain scores, lower total dose of analgesics and a trend for more adverse events in the vNOTES group. Conclusions vNOTES is non‐inferior to laparoscopy for a successful adnexectomy without conversion. vNOTES allowed shorter operating times and less postoperative pain but there was a trend for more adverse events.

show abstract

“…Through the experiments, we observed the size of the microneedle robot affects the efficacy of gastrointestinal transit. Because of the slow gastric emptying times over 24 hours and the narrow pylorus in minipig models ( 48 ), the prepared 30-mm-long microneedle robots did not appear in the intestine until the fifth day, and the long pylorus-passing time caused four of the five microneedle robots to be crushed into pieces by intense gastric contractions (fig. S22A).…”

Section: Resultsmentioning

confidence: 99%

“…S22). However, the transit time of nondissolving solids for humans (1.2 to 2 hours) has been reported much faster than that of minipigs (>24 hours) because of the more relaxed pyloric closure and upright position (48)(49)(50). Through optimizing the mechanical balance between the stretchable membrane and the absorbent hydrogels, the swellable microneedle robot can have a small initial size and a high expansion rate, which may further shorten the gastric transit time.…”

Section: Discussionmentioning

confidence: 99%

Pain-free oral delivery of biologic drugs using intestinal peristalsis–actuated microneedle robots

Gao,

Li,

et al. 2024

Sci. Adv.

View full text Add to dashboard Cite

Biologic drugs hold immense promise for medical treatments, but their oral delivery remains a daunting challenge due to the harsh digestive environment and restricted gastrointestinal absorption. Here, inspired by the porcupinefish’s ability to inflate itself and deploy its spines for defense, we proposed an intestinal microneedle robot designed to absorb intestinal fluids for rapid inflation and inject drug-loaded microneedles into the insensate intestinal wall for drug delivery. Upon reaching the equilibrium volume, the microneedle robot leverages rhythmic peristaltic contraction for mucosa penetration. The robot’s barbed microneedles can then detach from its body during peristaltic relaxation and retain in the mucosa for drug releasing. Extensive in vivo experiments involving 14 minipigs confirmed the effectiveness of the intestinal peristalsis for microrobot actuation and demonstrated comparable insulin delivery efficacy to subcutaneous injection. The ingestible peristalsis-actuated microneedle robots may transform the oral administration of biologic drugs that primary relies on parenteral injection currently.

show abstract

Gastric Emptying is Delayed in Transgastric Notes: A Randomized Study in Swine

Cited by 7 publications

References 31 publications

Consensus on safe implementation of vaginal natural orifice transluminal endoscopic surgery (vNOTES)

Consensus on safe implementation of vaginal natural orifice transluminal endoscopic surgery (vNOTES)

Adnexectomy by vaginal Natural Orifice Transluminal Endoscopic Surgery versus laparoscopy: results of a first randomised controlled trial (NOTABLE trial)

Pain-free oral delivery of biologic drugs using intestinal peristalsis–actuated microneedle robots

Contact Info

Product

Resources

About