Gastric-filling ultrasonography to evaluate gastric motility in patients with Parkinson's disease

Zou, Xianwei; Chen, Xiaqing; Wen, Yanxia; Jing, Xiaofeng; Luo, Man; Xin, Fengyue; Tang, Yao; Hu, Mengfei; Liu, Jian; Xu, Fan

doi:10.3389/fneur.2024.1294260

Cited by 2 publications

References 72 publications

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Utility of gut-brain electrophysiological coupling in predicting L-Dopa induced dyskinesia in Parkinson’s Disease

Houde,

Kaur,

Tiwari

et al. 2024

Preprint

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In this study, we focus on Levodopa induced dyskinesia (LID) condition in Parkinsons Disease (PD) and investigate the mechanistic role of gut brain coupling in explaining the dyskinesia severity. Earlier studies have provided evidences for abnormal dynamics in the cortico basal ganglia loops and also in the gut functioning, for explaining LID. However to our knowledge, assessing gut brain coupling isnt a standard practice for development of the treatment strategy in LID patients for understanding the odds of dyskinesia onset and progression. In this study, we use scalable data acquisition technologies such as electroencephalography (EEG) and electrogastrography (EGG) for investigating the gut brain coupling, and for the first time assess its utility to inform about dyskinesia severity in PD patients. We collected data from N 67 subjects (healthy 26) in middle to old age adulthood and acquire their gut brain coupling data during various cognitive engagement tasks, using simultaneous EEG and EGG recording setup. Some of our results include that gut-brain coupling can predict the severity of dyskinesia in PD during interoception, especially in hyperventilating and eyes closed resting state paradigms. Second, specific frequencies of gut coupling activity are more sensitive to explaining motor complications. Third, the gut activity differentially couples with different brain regions to explain the symptom severity. The most salient features of our model were the normogastric gut coupling with the temporo occipital brain region, normogastric gut coupling with the frontal region, and the tachygastric gut coupling with the centro parietal region. Furthermore of translational significance, the latter two features also significantly interacted with cardiac measures, and the model was able to predict sensitive heart rate variability levels for reducing the symptom severity. Altogether, our study paves way for utitlizing gut brain coupling as a clinical measure for strategizing interventions in PD.

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Utility of gut-brain electrophysiological coupling in predicting L-Dopa induced dyskinesia in Parkinson’s Disease

Houde,

Kaur,

Tiwari

et al. 2024

Preprint

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Evaluation value of ultrasound on gastrointestinal function in patients with acute heart failure

Hao,

Zheng,

Zhao

et al. 2024

Front. Cardiovasc. Med.

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ObjectiveTo study the changes in gastrointestinal wall thickness, blood flow, motility, and symptoms in patients with acute heart failure, and to assess gastrointestinal function by ultrasound.MethodsIn this study, patients diagnosed with acute heart failure were selected as the study group, and healthy individuals were selected as the control group. Both groups collected general data and completed the Chinese version of the gastrointestinal symptom rating scale. Ultrasonography was used to measure several abdominal vascular and gastrointestinal-related indicators. Statistical analysis used grouped comparison and correlation analysis.ResultsThe study group scored higher than the control group in total score, lower abdominal symptom score, constipation score, and difficult defecation score (Z = −2.828, −2.022, −2.015, −2.015, all P < 0.05). The hepatic vein diameter, superior mesenteric vein inner diameter and wall thickness of the ascending colon in the study group were significantly higher than those in the control group (t = 9.543, P < 0.001; t = 2.277, P = 0.025; Z = −2.062, P = 0.039). Antral contraction amplitude, antral contraction frequency, motility index, jejunal peristalsis frequency, and ascending colon peristalsis frequency were significantly lower in the study group compared to the control group (Z = −2.571, −4.196, −3.681, −5.451, −4.061, all P < 0.001). The wall thickness of the antrum, jejunum, and ascending colon were positively correlated with the diameter of the hepatic vein (r = 0.394, P = 0.011; r = 0.352, P = 0.024; r = 0.450, P = 0.003). Motility index and ascending colon peristalsis frequency were positively correlated with the peak velocity of superior mesenteric vein (r = 0.456, P = 0.029; r = 0.507, P = 0.007). The wall thickness of the jejunum was positively correlated with the peak velocity of superior mesenteric artery (r = 0.330, P = 0.035). Peak velocity of superior mesenteric artery, antral contraction frequency, and jejunal peristalsis frequency were negatively correlated with the reflux score (r = −0.409, P = 0.038; r = −0.423, P = 0.032; r = −0.409, P = 0.038). The wall thickness of the ascending colon was positively correlated with the reflux score (r = 0.414, P = 0.035).ConclusionThis study found that patients with acute heart failure exhibited thickening of the gastrointestinal wall and generally reduced gastrointestinal motility, with predominantly lower abdominal symptoms. These findings indicate that ultrasound can effectively monitor the gastrointestinal structure and function of patients with acute heart failure, which is expected to provide help for clinical diagnosis and treatment.

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Gastric-filling ultrasonography to evaluate gastric motility in patients with Parkinson's disease

Cited by 2 publications

References 72 publications

Utility of gut-brain electrophysiological coupling in predicting L-Dopa induced dyskinesia in Parkinson’s Disease

Utility of gut-brain electrophysiological coupling in predicting L-Dopa induced dyskinesia in Parkinson’s Disease

Evaluation value of ultrasound on gastrointestinal function in patients with acute heart failure

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