Gastric gland metaplasia in the small and large intestine.

Yokoyama, Itsuo; Kozuka, Satoshi; Ito, Keiichi; Kubota, Keiichi; Yokoyama, Yoshito

doi:10.1136/gut.18.3.214

Cited by 35 publications

(17 citation statements)

References 11 publications

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“…Pyloric gland metaplasia also has a strong association with Crohn’s Disease in patients with refractory pouchitis and correlates with attendant eosinophilic inflammatory infiltrates [5]. Interestingly, while pyloric metaplasia has been noted in Crohn’s colitis, it appears to be extremely rare in ulcerative colitis [3]. While these studies have established the connection of pyloric gland metaplasias with Crohn’s Disease, they do not address whether these metaplastic lineages directly contribute to resolution of mucosal injury.…”

Section: Pyloric Metaplasia In the Intestinementioning

confidence: 99%

Pyloric metaplasia, pseudopyloric metaplasia, ulcer‐associated cell lineage and spasmolytic polypeptide‐expressing metaplasia: reparative lineages in the gastrointestinal mucosa

Goldenring

2018

The Journal of Pathology

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Summary The gastrointestinal mucosae provide a critical barrier between the external and internal milieu. Thus, damage to the mucosa requires an immediate response to provide appropriate wound closure and healing. Metaplastic lineages with phenotypes similar to the mucous glands of the distal stomach or Brunner’s glands have been associated with various injurious scenarios in the stomach, small bowel and colon. These lineages have been assigned various names including pyloric metaplasia, pseudopyloric metaplasia, Ulcer-associated cell lineage (UACL) and spasmolytic polypeptide-expressing metaplasia (SPEM). A re-examination of the literature on these various forms of mucous cell metaplasia suggests that pyloric type mucosal gland lineages may provide a ubiquitous response to mucosal injury throughout the gastrointestinal tract as well as in the pancreas, esophagus and other mucosal surfaces. While the cellular origin of these putative reparative lineages likely varies in different regions of the gut, their final phenotypes may converge on a pyloric type gland dedicated to mucous secretion. In addition to their healing properties in the setting of acute injury, these pyloric type lineages may also represent precursors to neoplastic transitions in the face of chronic inflammatory influences. Further investigations are needed to determine how discrete molecular profiles relate to the origin and function of pyloric-type metaplasias previously described by histological characteristics in multiple epithelial mucosal systems in the setting of acute and chronic damage.

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Section: Pyloric Metaplasia In the Intestinementioning

confidence: 99%

Pyloric metaplasia, pseudopyloric metaplasia, ulcer‐associated cell lineage and spasmolytic polypeptide‐expressing metaplasia: reparative lineages in the gastrointestinal mucosa

Goldenring

2018

The Journal of Pathology

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“…32,34,37 Pyloric gland metaplasia also has been described in several other organs such as the pancreas, the gallbladder and the small and large intestine. [49][50][51][52] Pathogenesis of this metaplastic change in most organs is still under discussion; however, its relationship to carcinogenesis in the pancreas has received particular attention. In the pancreas, pyloric gland metaplasia is a common histological change of the pancreatic duct, and Kodama and Mori 53 have suggested that this metaplastic lesion might transform into atypical proliferations and then into adenocarcinomas.…”

Section: Endocervical Adenocarcinoma With Hyperplasiamentioning

confidence: 99%

Endocervical adenocarcinomas associated with lobular endocervical glandular hyperplasia: a report of four cases with histochemical and immunohistochemical analyses

et al. 2005

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We report on four cases of endocervical adenocarcinoma associated with lobular endocervical glandular hyperplasia using histochemical and immunohistochemical analyses. The patients ranged in age from 59 to 67 years (mean 62 years). Chief complaints were watery vaginal discharge in two cases, genital bleeding in one and no subjective symptoms in one. Cytological examinations of the cervical smears revealed adenocarcinoma cells and benign-looking glandular cells with intracytoplasmic golden-yellow mucin in all cases. Radical hysterectomy was performed in three patients, and simple total hysterectomy was performed in one. From surgical specimens, three tumors were diagnosed as mucinous adenocarcinoma and one was adenocarcinoma in situ. All adenocarcinomas were located proximally on the cervix, and did not involve the transformation zone. Adjacent to carcinoma tissues in the cervix, lobular endocervical glandular hyperplasia was detected. The cells of lobular endocervical glandular hyperplasia were dominantly positive with neutral mucin, and immunohistochemistry revealed that these cells had prominent pyloric gland mucin (HIK1083). Focal immunopositivity for pyloric mucin was also observed in three adenocarcinomas. Either CEA or p53 were immunopositive in all adenocarcinomas and negative in the tissues of lobular endocervical glandular hyperplasia. Histopathological features of the present cases suggest that some endocervical adenocarcinomas may originate from lobular endocervical glandular hyperplasia. Keywords: endocervical adenocarcinoma; lobular endocervical glandular hyperplasia; gastric mucin; HIK1082; immunohistochemistry; histochemistry Endocervical adenocarcinomas account for 10-15% of all cervical cancers and have been increasing in relative and absolute numbers.1-4 Therefore, understanding the precursor lesions of endocervical adenocarcinoma has become more important for gynecologists and pathologists. Endocervical glandular dysplasia and atypical tubal metaplasia are recognized premalignant lesions, and a considerable number of studies on these lesions have been conducted so far. [5][6][7][8][9][10][11][12][13] Consequently, the question arises whether other precursors exist. Microglandular hyperplasia, 14-17 mesonephric hyperplasia, 18,19 tunnel clusters, 20-22 diffuse laminar endocervical glandular hyperplasia 23 and lobular endocervical glandular hyperplasia are currently considered benign hyperplastic glandular lesions in the uterine cervix, 24 but little is really known about their relationship with endocervical carcinomas. 25,26 Recently, several studies have focused on gastric mucin (or pyloric gland mucin) in glandular lesions of the cervix and its connection with endocervical glands' carcinogenesis. Gastric phenotype has been described in endocervical gastric metaplasia, lobular endocervical

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“…The frequency of PGM in CD ranged from 27% to 78% 18, 39, 40 . It is not clear whether PGM is a specific histological finding for CD of the small bowel or simply reflects chronic inflammation and damage to the small bowel 18, 19, 39, 41–44 . In one study, PGM was shown to be associated with activity and severity of CD, but not with symptom duration 18 .…”

Section: Discussionmentioning

confidence: 99%

Pyloric gland metaplasia and pouchitis in patients with ileal pouch‐anal anastomoses

Kariv¹,

Plesec²,

Gaffney³

et al. 2010

Aliment Pharmacol Ther

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Gastric gland metaplasia in the small and large intestine.

Cited by 35 publications

References 11 publications

Pyloric metaplasia, pseudopyloric metaplasia, ulcer‐associated cell lineage and spasmolytic polypeptide‐expressing metaplasia: reparative lineages in the gastrointestinal mucosa

Pyloric metaplasia, pseudopyloric metaplasia, ulcer‐associated cell lineage and spasmolytic polypeptide‐expressing metaplasia: reparative lineages in the gastrointestinal mucosa

Endocervical adenocarcinomas associated with lobular endocervical glandular hyperplasia: a report of four cases with histochemical and immunohistochemical analyses

Pyloric gland metaplasia and pouchitis in patients with ileal pouch‐anal anastomoses

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