Gastric glomus tumor with a preoperative diagnosis by endoscopic ultrasonography-guided fine needle aspiration: a case report

Abstract

A gastric glomus tumor (GGT) is a rare gastric submucosal tumor that can become malignant. A preoperative diagnosis would allow for a more informed decision regarding the treatment strategy. We present the case of an asymptomatic man with a GGT that was diagnosed during a preoperative examination. Upper gastrointestinal endoscopy was performed in a 64-yearold man and revealed a submucosal tumor at the lesser curvature of the antrum of the stomach. Endoscopic ultrasonography showed a 12-mm-sized hypoechoic tumor in the second and third layers of the stomach wall. A histologic diagnosis of GGT was made using endoscopic ultrasonography-guided fine needle aspiration (EUS-FNA). Abdominal contrast-enhanced computed tomography was performed, but the identification of the tumor was difficult owing to poor enhancement. The gradual growth of the tumor made it necessary to perform an operation. Laparoscopy and endoscopy cooperative surgery was performed without any complications. The tumor cells were immunohistochemically positive for alpha-smooth muscle actin, h-caldesmon, and collagen type IV but were negative for desmin, discovered on GIST-1, S-100 protein, cluster of differentiation 34, epithelial membrane antigen, and cytokeratin AE1/AE3. The final diagnosis was identical to the preoperative diagnosis made using EUS-FNA. EUS-FNA is a useful method for the preoperative diagnosis of small submucosal tumors, including GGTs.

Gastric glomus tumor diagnosed by fine needle aspiration of the stomach: A report of two cases and review of the literature

“…In a review of 14 cases of gastric glomus tumors, 2,6,13,17–24 inclusive of our two cases, the cytomorphology of the cells from EUS‐FNA most often appeared as round to oval in shape, and uniform in appearance with clear to eosinophilic cytoplasm, fine chromatin, and inconspicuous nucleoli (Table 1). All 12 cases reported that the immunostains demonstrated positive alpha‐smooth muscle actin (SMA) expression, which helped support the diagnosis of glomus tumor.…”

A Rare Gastric Subepithelial Lesion Removed through Submucosal Tunneling Endoscopic Resection: Case Report and Literature Review

“…In a recent review, 46 cases of gastric glomus tumor were reported in the literature between 2010 and 2019, and only 19 of them had a preoperative diagnosis. Among the patients who underwent endoscopic ultrasound-guided fine-needle aspiration to determine the pathology, a diagnosis was correctly given in only 8 out of 13 cases [ 13 ]. Although EUS-guided biopsy has been reported to be able to provide an accurate diagnosis in some cases, resection might be a more favorable alternative for both diagnosis and treatment [ 4 , 14 ].…”

Tumor Glômico Gástrico: Um caso raro de neoplasia benigna

“…Tais estruturas estão envolvidas principalmente na regulação da temperatura central e na homeostase, consistindo num shunt arteriovenoso (o canal Sucquet-Hoyer) (Bai, et al, 2021;Chabowski, et al, 2016;Gupta, et al, 2020;Tantia, et al, 2021;Vig, et al, 2017). Esta lesão no sistema gástrico foi primeiramente descrita em 1951 por Kay e colaboradores, e hoje representa aproximadamente 1 % de todas as neoplasias mesenquimais gástricas que surgem na submucosa e na muscular própria (Alsahwan, et al, 2021;Aoba, et al, 2018;Hasuda, et al, 2021;Xing, et al, 2022).…”