Gastric Hyperplastic Polyp Associated with Proliferation of Xanthoma Cells Observed by Magnification Narrow-Band Imaging Endoscopy

Shoji, Hirokazu; Kubo, Motoharu; Inoue, Atsushi

doi:10.1155/2009/845260

Cited by 7 publications

(4 citation statements)

References 11 publications

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“…Most of the times no treatment is required13 14 but careful follow-up with endoscopy is needed to see its behaviour 15. In some reports, gastric xanthelasma has been treated with endoscopic mucosal resection in the presence of associated polyps 16. In some cases, endoscopic argon beam treatment showed good results and heat probe therapy was found to heal the lesions in almost all patients 17.…”

Section: Discussionmentioning

confidence: 99%

Gastric xanthelasma: an unusual endoscopic finding

Dhakal¹,

Dhakal²,

Bhandari

et al. 2013

BMJ Case Reports

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Gastric xanthelasma is a rarely encountered finding in upper gastrointestinal (GI) endoscopy. It is characterised by yellowish-white plaque in the stomach especially in the antrum or the pyloric region. Histologically it consists of foamy macrophages in the lamina propria. It is a benign condition but its appearance mimics malignancy and it is found to be associated with various conditions, some of which are considered premalignant so, histological confirmation is necessary. We present a case of a 44-year-old man who presented to the medicine outpatient department for intermittent pain in epigastrium for the last 2 years. His physical examination was normal. His haematological and biochemical investigations were also normal. His upper GI endoscopy revealed yellowish-white plaque in fundus of the stomach, which was diagnosed as gastric xanthelasma by histological examination with associated chronic gastritis.

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Section: Discussionmentioning

confidence: 99%

Gastric xanthelasma: an unusual endoscopic finding

Dhakal¹,

Dhakal²,

Bhandari

et al. 2013

BMJ Case Reports

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“…There seem to be various possible causes underlying the development of xanthoma, such as an anomaly in lipid metabolism or inflammatory changes in the gastric mucosa. It has been reported that gastric xanthomas are accompanied by various gastric lesions including intestinal metaplasia [21], hyperplastic polyps [22], and gastric cancer [23]. A close relationship among gastric xanthoma, H. pylori infection, and atrophic gastritis was also reported [24,25].…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological Assessment of Gastric Xanthoma as Potential Predictive Marker of Gastric Cancer

Kitamura¹,

Muguruma²,

Okamoto³

et al. 2017

Digestion

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Background/Aims: Gastric xanthomas are frequently observed in the stomach as small yellowish plaques or nodules. A close relationship among Helicobacter pylori infection, atrophic gastritis, and xanthomas has been reported. We assessed the clinicopathological features of gastric cancer with or without xanthomas. Methods: A total of 91 patients who were diagnosed as having early gastric cancer were enrolled. We evaluated the gastritis status using scores for gastritis and atrophy, positivity of H. pylori infection, the prevalence rate of xanthomas, and the clinicopathological features of gastric cancer. Results: Gastric xanthomas were observed in 72.5% of early gastric cancer cases. Scores for gastritis and atrophy were significantly higher in the xanthoma-positive group than those in the xanthoma-negative group. A higher prevalence of differentiated-type adenocarcinoma was found in the xanthoma-positive group. Among the cases with multiple gastric xanthomas, the prevalence of males was significantly higher than that of females. Conclusion: A high prevalence rate of gastric xanthomas in gastric cancer cases was shown. Xanthomas were highly associated with age, the severities of gastritis and atrophy, and differentiated-type adenocarcinoma. Regardless of the eradication of H. pylori, xanthomas may be useful predictive markers for the development of differentiated-type adenocarcinoma.

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“…The prevalence of dyspepsia has been increasing, making it one of the primary reasons patients seek medical attention from gastroenterologists [ 5 ]. According to a review article published in the Journal of Gastroenterology & Hepatology , functional dyspepsia (i.e., stretching, contractions, and spasms of a structurally normal stomach causing symptoms) accounts for most cases of chronic dyspepsia [ 6 ]. In this article, we discuss a patient who required further investigation after failing first-line treatment for presumed functional dyspepsia.…”

Section: Discussionmentioning

confidence: 99%

A Large Xanthomatous Hyperplastic Polyp: An Unusual Case of Dyspepsia

Escalante,

Schneider

2024

Cureus

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Gastric hyperplastic polyps (GHP) are one of the most common gastric epithelial polyps. They are generally asymptomatic and often discovered incidentally during endoscopic procedures. In this article, we present the case of a 36-year-old patient with dyspepsia attributed to the prolapse of a large gastric hyperplastic polyp with extensive xanthomatous change. The endoscopic findings revealed that the motion of the large polyp caused an intermittent pyloric obstruction. The large polyp was removed through a successful snare polypectomy, resolving the patient's symptoms. While dyspepsia is predominantly associated with functional causes, it is crucial to consider structural factors like GHP, particularly in the case of large polyps, as part of the differential diagnosis.

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Gastric Hyperplastic Polyp Associated with Proliferation of Xanthoma Cells Observed by Magnification Narrow-Band Imaging Endoscopy

Cited by 7 publications

References 11 publications

Gastric xanthelasma: an unusual endoscopic finding

Gastric xanthelasma: an unusual endoscopic finding

Clinicopathological Assessment of Gastric Xanthoma as Potential Predictive Marker of Gastric Cancer

A Large Xanthomatous Hyperplastic Polyp: An Unusual Case of Dyspepsia

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