Gastric Hyperplastic Polyps Associated with Proton Pump Inhibitor Use in a Case without a History of &lt;i&gt;Helicobacter pylori&lt;/i&gt; Infection

Miyamoto, Shuichi; Kato, Mototsugu; Matsumoto, Kana; Abiko, Satoshi; Tsuda, Momoko; Mizushima, Takeshi; Yamamoto, Keiko; Ono, Shouko; Kudo, Takahiko; Shimizu, Yuichi; Hatanaka, Kanako C.; Tsunematsu, Izumi; Sakamoto, Naoya

doi:10.2169/internalmedicine.56.8040

Cited by 30 publications

(40 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The indiscriminate use of PPIs leads to various changes of the gastric mucosa, such as parietal cell hyperplasia/parietal cell protrusion, characterised by protrusion of parietal cell cytoplasm into the lumen of oxyntic glands, and fundic gland cyst dilatation . PPI treatment also induces foveolar epithelial cell hyperplasia and foveolar hyperplastic polyps . Furthermore, recent studies have shown that patients on PPIs have a larger size and a higher incidence of FGPs than those not on PPIs .…”

Section: Introductionmentioning

confidence: 99%

“…[11][12][13] PPI treatment also induces foveolar epithelial cell hyperplasia and foveolar hyperplastic polyps. [14][15][16][17] Furthermore, recent studies have shown that patients on PPIs have a larger size and a higher incidence of FGPs than those not on PPIs. 14,16,[18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] Two systematic reviews showed an increased risk of FGPs with long-term PPI treatment.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Histological analysis of fundic gland polyps secondary to PPI therapy

et al. 2019

View full text Add to dashboard Cite

Aims The aim of this study was to clarify the histopathological features of fundic gland polyps (FGPs) in patients treated with proton pump inhibitors (PPIs) and to investigate the mechanism of enlargement of FGPs after PPI treatment. Methods and results A total of 196 biopsy specimens of FGPs, which consisted of 87 FGPs in patients treated with PPIs (PPI group) and 109 FGPs in patients treated without PPIs (non‐PPI group) were compared histologically using haematoxylin and eosin staining, Ki67 immunohistochemistry and multiplex immunohistochemical stain with Ki67, MUC5AC and MUC6. The significant histological features of FGPs in the PPI group were: larger size of dilated fundic gland cysts, larger number of foveolar and mixture type fundic gland cysts, foveolar cell hyperplasia, parietal cell protrusion, mononuclear cell infiltration and a higher percentage of Ki67‐positive cells in the deeper layers of the glands. Multiplex immunohistochemical stain showed that Ki67‐positive cells were also positive for MUC5AC, and the Ki67‐positive rate was significantly higher in MUC5AC‐positive cells of the PPI group than of the non‐PPI group. Gene mutations of β‐catenin were found in only 9.7% of FGPs in the PPI group. Conclusions Enlargement of fundic gland cysts due to foveolar cell proliferation and parietal cell protrusion might promote the enlargement of FGPs in patients treated with PPIs. β‐catenin gene mutations might not be associated with these histological changes of FGPs after PPI treatment.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Histological analysis of fundic gland polyps secondary to PPI therapy

et al. 2019

View full text Add to dashboard Cite

show abstract

“…This is what is usually observed in developed countries where the prevalence of H. pylori infection is low and the use of PPI is high (2). Recent studies have indicated that HPs occur after long-term use of PPIs in patients without H. pylori infection (31,32). PPIs may stimulate the secretion of gastrin, leading to hyper-gastrinaemia.…”

Section: Discussionmentioning

confidence: 79%

Gastric hyperplastic polyps inversely associated with current Helicobacter�pylori infection

Wang

et al. 2020

Exp Ther Med

View full text Add to dashboard Cite

The incidence of gastric hyperplastic polyps (HPs) has been on the rise in recent years. The contribution of Helicobacter pylori infection to this trend has remained to be elucidated. The present study aimed to explore the association between HPs and H. pylori in China, an area with a high infection rate of H. pylori. In order to study trends of HPs and H. pylori infection over the past decades, cases encountered from 2009 to 2018 were assessed and a total of 109,150 consecutive patients who underwent esophagogastroduodenoscopy at Qingdao Municipal Hospital (Qingdao, China) were enrolled. The incidence of HPs and the prevalence of H. pylori were determined and their correlation was explored. Gastric HPs were detected in 1,497 patients (1.6%) who received gastric biopsies. The incidence of HPs exhibited a rising trend, with a ~4-fold increase in the annual detection rate from 2009 to 2018. The prevalence of H. pylori infection was inversely associated with the prevalence of HPs (adjusted odds ratio, 0.66). The prevalence of H. pylori in the examined cohort decreased with time (r=-0.76, P=0.011). The decreasing trend of H. pylori infection was negatively correlated with the rising trend of HPs (r=-0.64, P=0.048), further indicating an inverse association between them. The difference in the prevalence of HPs between H. pylori-negative and-positive patients increased with age (r=0.80, P=0.018). The age-associated increase was slower in H. pylori-infected patients. The decline in H. pylori infection with time appeared to not be associated with the birth cohort effect, suggesting the decline was not caused by exposure to environmental factors during an early period of life. The present results indicated that the incidence of gastric HPs increased with the decline in H. pylori infection, demonstrating an inverse association between the occurrence of HPs and the infection.

show abstract

“…These polyps are not always diagnosed as endoscopic biopsies because they are local [33] . Because our case was not diagnosed by endoscopic biopsy, it was diagnosed after surgical removal [34] .…”

Section: Discussionmentioning

confidence: 94%

“…The frequency of polyps increases due to the frequency of H. pylori infection and increased use of PPIs . Many studies have shown an increase in the frequency of FGPs in patients using PPIs [34] . This relationship can cause anxiety among doctors and patients who need to use PPIs for a long time.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of gastric polyps in patients with upper gastrointestinal endoscopy

Zheng

Wen

Dai

et al. 2019

Preprint

View full text Add to dashboard Cite

BACKGROUNDAccording to the study population, incidence of gastric polyps (GP) varies from 0.33% to 6.7% in various studies. Most GPs consist of proliferative polyps (HP), gastric fundus polyps (FGP) and adenomatous polyps (APs). Despite the high malignant AP potential, sporadic FGP has no malignant potential. On the contrary, HP has a lower risk of potential harm. It is not sufficient to perform biopsies to determine the presence of polyp types and displacements, therefore, some polyps may require extensive biopsy or complete resection. METHODS This retrospective study included GP patients or polyphenic lesions with polyps or malignant histologyfound in polyps or gastroscopy at the Department of Gastroenterology, Shaanxi Hospital of Traditional Chinese Medicine from 2017 to 2019. RESULTSIn a series of 10.000 upper gastrointestinal endoscopy, 384 patients (0.38%) were found to have GPs.Of these patients, 98 (25.5) were male and 286(74.5) were female. The average age of the patients

show abstract

Gastric Hyperplastic Polyps Associated with Proton Pump Inhibitor Use in a Case without a History of <i>Helicobacter pylori</i> Infection

Cited by 30 publications

References 28 publications

Histological analysis of fundic gland polyps secondary to PPI therapy

Histological analysis of fundic gland polyps secondary to PPI therapy

Gastric hyperplastic polyps inversely associated with current Helicobacter�pylori infection

Evaluation of gastric polyps in patients with upper gastrointestinal endoscopy

Contact Info

Product

Resources

About