Gastric inhibitory polypeptide (GIP) responses in primary diabetes

Alam, M.J.; Buchanan, K.D.

doi:10.1016/0167-0115(80)90023-3

Cited by 7 publications

(3 citation statements)

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“…Recognition that GIP participates in the enteroinsular axis prompted investigations into its role in the pathophysiotogy of diabetes mellitus. Both increased and decreased GIP concentrations have been described in response to glucose, mixed meal and fat stimulation in diabetes mellitus [12][13][14][15][16][17][18][19][20]. Despite this large series of studies which have measured GIP concentrations in response to various stimuli, limited data is available regarding the effects of an intravenous infusion of GIP in diabetes mellitus [21,22].…”

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confidence: 99%

The effects of glucose-dependent insulinotropic polypeptide infused at physiological concentrations in normal subjects and Type 2 (non-insulin-dependent) diabetic patients on glucose tolerance and B-cell secretion

et al. 1987

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The effects of porcine glucose-dependent insulinotropic polypeptide given by continuous intravenous infusion in normal subjects (n = 6) and Type 2 (non-insulin-dependent) diabetic patients (n = 6) have been investigated. The subjects were studied on 2 separate days after overnight fasts. On each day 25 g of glucose was infused from 0-30 min plus an infusion of either porcine glucose-dependent insulinotropic polypeptide (0.75 pmol . kg-1 . min-1) or control solution. During the glucose-dependent insulinotropic polypeptide infusion plasma glucose values were reduced in normal subjects from 30-60 min (p less than 0.01) and in Type 2 diabetic patients at 45 and 60 min (p less than 0.05). In the normal subjects insulin concentrations were greater from 10-35 min (p less than 0.01) following glucose-dependent insulinotropic polypeptide infusion and peak values were increased by 123%. In the Type 2 diabetic patients following glucose-dependent insulinotropic polypeptide infusion insulin levels were increased from 4-40 min (p less than 0.01) but peak values were only increased by 27%. In the normal subjects C-peptide values were greater from 25-45 min (p less than 0.01) following glucose-dependent insulinotropic polypeptide infusion and peak C-peptide levels were increased by 82%. In the Type 2 diabetic patients following the glucose-dependent insulinotropic polypeptide infusion C-peptide levels were increased from 6-55 min (p less than 0.01) and peak values were increased by 20%. Plasma glucose-dependent insulinotropic polypeptide levels were within the physiological post prandial range during the glucose-dependent insulinotropic polypeptide infusion.(ABSTRACT TRUNCATED AT 250 WORDS)

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confidence: 99%

The effects of glucose-dependent insulinotropic polypeptide infused at physiological concentrations in normal subjects and Type 2 (non-insulin-dependent) diabetic patients on glucose tolerance and B-cell secretion

et al. 1987

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“…Different investigators using different RIA systems found normo-, hypo-and hyperGIPemia in type 2 diabetes [7][8][9][10][11][12][13][14]. Using the same assay system employing three different porcine GIP antisera, we have found hypo-and normoGIPemia in type 2 diabetes.…”

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confidence: 75%

“…As a result, considerable investigations have been performed to define the role of GIP in type 2 diabetes. Using different radioimmunoassay (RIA) systems, following oral glucose load, grossly different and conflicting data on GIP in type 2 diabetes have been published [7][8][9][10][11][12][13][14]. The present work was therefore undertaken to study GIP responses in type 2 diabetes using three different antisera in the same assay system.…”

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confidence: 99%