Gastric Intrinsic Factor and Cobalamin Absorption

Vitamin B12

“…The structural specificity for the binding of cobalamin by intrinsic factor is rather complex, but the 5,6-dimethylbenzimidazole moiety is absolutely essential (Seetharam and Alpers, 1991). Cyanocobalamin, hydroxocobalamin, methylcobalamin, or adenosylcobalamin all bind to intrinsic factor with approximately the same high affinity (Donaldson, 1987).…”