Gastric Irradiation in the Treatment of Peptic Ulcer

Clayman, Charles Β.; Palmer, Walter L.; Kirsner, Joseph B.

doi:10.1016/s0016-5085(19)34051-x

Cited by 17 publications

(5 citation statements)

References 14 publications

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Section: Discussionmentioning

confidence: 99%

“…The goal of gastric irradiation is to suppress hydrochloric acid secretion and permit healing of complicated peptic ulcers (4). Although the effect on acid secretion may be only temporary (4, 5), gastric irradiation has helped to reduce the recurrence rate of peptic ulcer (4). Levin et al (10) found a decrease of the recurrence rate from 102 to 17 per 100 patient‐years, as well as a decrease of bleeding episodes from 4.1 to 1.1 and of perforations from 0.2 to 0.1 per 100 patient‐years.…”

Section: Discussionmentioning

confidence: 99%

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Gastric Irradiation for Complicated Peptic Ulcer in Geriatric Patients*

Anselm

Schuman

1972

J American Geriatrics Society

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Thirty-six elderly patients with complicated peptic ulcer were treated by gastric irradiation (2000 roentgens directed at the fundus). In 30 of the 36 cases there was a significant improvement in symptoms. A marked decrease of hydrochloric acid secretion was observed in the 15 tested before and after therapy.Gastric irradiation offers a safe means of treatment for complicated peptic Glcer in patients who, because of advanced age or associated disease, are poor surgical risks.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Gastric Irradiation for Complicated Peptic Ulcer in Geriatric Patients*

Anselm

Schuman

1972

J American Geriatrics Society

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“…It has long been known that relatively low dose radiation, i.e., 1,500-1,600 rad, given in 10 daily doses to the entire stomach causes a significant reduction, sometimes for many years, of gastric acidity and has been used in treatment of peptic ulcer disease [25,26]. Following these doses of radiation, there is a loss of chief cell and parietal cell granules.…”

Section: Stomachmentioning

confidence: 99%

Pathologic changes secondary to radiation

Berthrong

1986

World j. surg.

127

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In order to be effective in the treatment of disease, especially neoplastic disease, radiation necessarily needs to be given in large doses. When treating tumors with high radiosensitivity in tissue of relatively low radiosensitivity, few complications of therapy occur. Frequently, however, the differential of sensitivity to radiation between the neoplasm and normal tissues exposed is small and the incidence of radiation injury to normal tissues becomes significant. Nowhere is this more apparent than in treatment of neoplasms during which the alimentary canal is heavily radiated. The following discussion will describe the pathologic changes that occur in the various units of the exposed alimentary tract and in various components of those units during and especially months or years after radiation therapy. The usual rapid and effective regeneration of the rapid-renewal cell system after injury will be noted. The serious delayed manifestations of injury to the fibrovascular tissues with resulting delayed complications of ulcerations, stenoses, fistula formation, and obstructing adhesions will be emphasized. Brief discussions of several other organ systems injured by radiation will be presented.The development of second neoplasms as a result of radiation will be briefly mentioned and discussed from three standpoints: very low levels, low levels, and high levels of radiation.

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“…This method was introduced in Chicago in 1937 (Palmer and Templeton, 1939) and the results and conclusions have recently been reviewed (Clayman et al. 1968) .…”

Section: Gastric Irradiationmentioning

confidence: 99%