Gastric Lesions: Demonstrated by Transabdominal Ultrasound After Oral Administration of an Echoic Cellulose-Based Gastric Ultrasound Contrast Agent

Liu, Z; Guo, Jintao; Li, J.; Wang, S.; Tang, Shijia; Xie, Liangdi; Huang, Ying; Lu, Wenming; Ren, Weidong; Sun, Shiwei; Huang, Liping

doi:10.1055/s-0034-1399719

Cited by 10 publications

(14 citation statements)

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“…Previous comparative studies have shown that TUS-OCCA could accurately detect a variety of gastric lesions, with a 77.8-100.0% sensitivity range and a 94.0-100% specificity range Liu et al 2014aLiu et al , 2014bLiu et al , 2015aLiu et al , 2015bShen et al 2014;Shi et al 2012;Wei et al 2013). Li et al (2012) showed that morphologic features in 350 cases of gastric cancer, including 53 lesions in the cardia, 70 in the fundus, 90 in the body, 99 in the antrum and 38 in the pylorus, were clearly demonstrated by TUS.…”

Section: Discussionmentioning

confidence: 97%

“…With the remarkable improvements in sonographic equipment, TUS is increasingly used for the detection and evaluation of gastrointestinal lesions Liu et al 2014aLiu et al , 2014bMa et al 2015;Maconi et al 2009;Nylund et al 2013;Shen et al 2014;Shi et al 2012;Wei et al 2013). Moreover, TUS-OCCA has recently been suggested by some authors to be a valuable initial screening tool for gastric lesions in selected patients Liu et al 2014aLiu et al , 2014bLiu et al , 2015aLiu et al , 2015bShen et al 2014;Shi et al 2012;Wei et al 2013). The benefits of the mid-high echoic cellulose-based gastrointestinal contrast agent include the following: (i) the uniformly mid-high level of echogenicity facilitates ultrasound visualization of hypoechoic gastric lesions; (ii) possibly fewer gas artifacts with the contrast compared with water because of the greater bulk and better surface tension properties of the cellulose-based contrast agent, which optimize the displacement of gas and interfere with mural gas adherence; and (iii) better detection of small gastric lesions due to greater flattening of the gastric mucosal folds by the thin paste of the cellulose-based contrast agent.…”

Section: Discussionmentioning

confidence: 99%

“…In this study, subgroup analysis showed a significant difference (p , 0.05, Fisher's exact test) in the rates of detection of gastric ulcer by TUS-OCCA between group S (detection rate 89%) and group U (detection rate 45%). Therefore, it is strongly suggested that screening by TUS-OCCA is performed mainly in non-obese individuals with a suitable body habitus in whom both cardia and pylorus can be visualized by TUS before administration of oral contrast (Liu et al 2014a(Liu et al , 2014b(Liu et al , 2015a(Liu et al , 2015b. Location of a lesion is an important factor in its detection.…”

Section: Discussionmentioning

confidence: 99%

“…Scanning procedure. The entire stomach was scanned in the following 5 steps (Liu et al 2014a(Liu et al , 2014b(Liu et al , 2015a(Liu et al , 2015b (Fig. 1):…”

Section: Methodsmentioning

confidence: 99%

“…Considering the remarkable advances in ultrasound technology, transabdominal ultrasound after oral administration of an echoic, cellulose-based, gastric ultrasound contrast agent (TUS-OCCA) has recently been suggested as a valuable initial screening tool for gastric lesions in selected patients Liu et al 2014aLiu et al , 2014bLiu et al , 2015aLiu et al , 2015bShen et al 2014;Shi et al 2012;Wei et al 2013). However, the value of TUS-OCCA in the detection and surveillance of gastric ulcer remains unclear.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Transabdominal Ultrasound with Oral Cellulose-Based Contrast Agent in the Detection and Surveillance of Gastric Ulcer

Liu

Guo

Wang

et al. 2017

Ultrasound in Medicine & Biology

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The aim of this study was to assess the role of transabdominal ultrasound with cellulose-based oral contrast agent (TUS-OCCA) in the detection and surveillance of gastric ulcer. The study was approved by the institutional review board at Shengjing Hospital of China Medical University. A total of 124 consecutive patients with benign gastric ulcer diagnosed by gastroscopy and biopsy were enrolled. Serial TUS-OCCA (approximately 1 exam every 2 wk) was performed to monitor the effects of treatment, and additional interventions were planned according to the results. TUS-OCCA detected gastric ulcer in 76% of patients (94 of 124). The detection rates for lesions of ≤5 mm, lesions of 5-10 mm, lesions of 10-15 mm and lesions >15 mm were 32% (10 of 31), 77% (27 of 35), 96% (25 of 26) and 100% (32 of 32), respectively. The detection rates for lesions located in the antrum, angle and body were 70%, 84% and 85%, respectively. Among 30 undetected lesions, which ranged 2-13 mm in size, 11 were at the antrum, 9 at the angle, 3 in the body, 6 at the cardia and 1 at the fundus. During the follow-up period, patients underwent a mean of 3.8 TUS-OCCA examinations (range 2-7), and ulcers were healed after 8 wk (range 2-12 wk) of standard therapy in 76 patients. Eighteen patients who did not show improvement after standard therapy underwent repeat gastroscopy with biopsy. Repeat biopsy was positive for gastric cancer in 4 of these: 2 of the remaining 14 were diagnosed with gastric cancer at gastrectomy, and 12 were diagnosed with chronic benign ulcer. These results indicate that serial TUS-OCCA can be used for close monitoring during routine treatment of gastric ulcers that are detectable by TUS-OCCA and that monitoring by TUS-OCCA can guide additional interventions. A non-invasive follow-up program based on TUS-OCCA can also help to detect gastric cancers that have been misdiagnosed as benign ulcers at the initial endoscopic biopsy.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Scanning procedure. The entire stomach was scanned in the following 5 steps (Liu et al 2014a(Liu et al , 2014b(Liu et al , 2015a(Liu et al , 2015b (Fig. 1):…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of Transabdominal Ultrasound with Oral Cellulose-Based Contrast Agent in the Detection and Surveillance of Gastric Ulcer

Liu

Guo

Wang

et al. 2017

Ultrasound in Medicine & Biology

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Preliminary opinion on assessment categories of stomach ultrasound report and data system (Su-RADS)

et al. 2018

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ObjectiveTransabdominal ultrasound after oral administration of an echoic cellulose-based gastric ultrasound contrast agent (TUS-OCCA) has recently been suggested as a valuable mass-screening tool for gastric cancer. The aim of this study was to propose a producible stomach ultrasound reporting and data system (Su-RADS) using TUS-OCCA for gastric cancer screening.PatientsThe study includes information of 2738 patients who underwent both gastroscopy and TUS-OCCA examinations recorded in software system. Gastroscopy examination with pathological diagnosis was considered as gold standard. Various gastric lesions were classified into category 1–5 based on gastric wall thicknesses of them (especially the mucosa layer).ResultsThe total malignant ratios of patients enrolled in this study were 17.1% (469/2738). The malignant ratios for category 1–5 were, respectively, 1.1, 1.7, 12.2, 34.2 and 78.1%. Category 2 indicated mild thickening of gastric wall at low risk for malignancy (1.7%); category 3 indicated moderate thickening at moderate risk for malignancy (12.2%); category 4 indicated severe thickening at high risk for malignancy (34.2%); category 5 indicated extremely severe thickening at extremely high risk for malignancy (78.1%). If category 2 was identified as cut-off point distinguishing between benign and malignant, the sensitivity and specificity by Su-RADS are 95.1 and 78.6%, respectively.ConclusionThe Su-RADS system could inform the physicians about key findings, indicating the risk for malignancy and necessity of additional gastroscopy examination. Prospectively randomly controlled study design with larger clinical trial is needed for further investigations.Electronic supplementary materialThe online version of this article (10.1007/s10120-018-0798-x) contains supplementary material, which is available to authorized users.

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Evaluation of Gastric Emptying by Transabdominal Ultrasound after Oral Administration of Semisolid Cellulose-Based Gastric Ultrasound Contrast Agents

Liu

et al. 2018

Ultrasound in Medicine & Biology

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Many previous studies have found that transabdominal ultrasound may allow precise measurement of gastric emptying of liquid meals. However, the clinical use of this technique has been hampered by the limitation that transabdominal ultrasound might not accurately measure gastric emptying of solid meals. It is more important to measure gastric emptying of solids instead of liquids, as gastric emptying of solids is more often delayed than gastric emptying of liquids in gastric motility disorders. Recently, transabdominal ultrasound after oral administration of a cellulose-based gastric contrast agents (TUS-OSCA) has been suggested to be effective in initial screening of gastric lesions. The aim of this study was to explore the accuracy of TUS-OSCA in the evaluation of gastric emptying of a semisolid meal. Twenty healthy young patients (10 males and 10 females aged 25.5 ± 2.5 y) were studied. Concurrent measurements of gastric emptying by scintigraphy and TUS-OSCA were performed after ingestion of 350 mL semisolid ultrasound agent labeled with 20 MBq Tc-sulfur colloid. There was no significant difference in the overall curves for gastric emptying time between scintigraphy and TUS-OSCA. There was a good correlation between the gastric 50% emptying times determined by scintigraphy (89.4 ± 1.8 min) and TUS-OSCA (92.5 ± 1.7 min). The correlation coefficient was r = 0.922 (p = 0.000). Current results indicate that TUS-OSCA is accurate, and the results are similar to those obtained by scintigraphy for gastric emptying of a semisolid meal.

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Gastric Lesions: Demonstrated by Transabdominal Ultrasound After Oral Administration of an Echoic Cellulose-Based Gastric Ultrasound Contrast Agent

Cited by 10 publications

References 0 publications

Evaluation of Transabdominal Ultrasound with Oral Cellulose-Based Contrast Agent in the Detection and Surveillance of Gastric Ulcer

Evaluation of Transabdominal Ultrasound with Oral Cellulose-Based Contrast Agent in the Detection and Surveillance of Gastric Ulcer

Preliminary opinion on assessment categories of stomach ultrasound report and data system (Su-RADS)

Evaluation of Gastric Emptying by Transabdominal Ultrasound after Oral Administration of Semisolid Cellulose-Based Gastric Ultrasound Contrast Agents

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