Gastric malignancies in Northern Jordan with special emphasis on descriptive epidemiology

Bani-Hani, Kamal E.; Yaghan, Rami J.; Heis, Hussein A.; Shatnawi, Nawaf J; Matalka, Ismail; Hani, Amjad Bani; Gharaibeh, Kamal A.

doi:10.3748/wjg.v10.i15.2174

Cited by 23 publications

(19 citation statements)

References 22 publications

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“…In addition, in line with previous reports [18][19][20][21], ageatdiagnosiswasassociatedwithstomachcancersurvival inthisstudy,althoughsomeauthorsfoundnoassociation [5, Jordan [29] Chile [30] Present study Samplesize,n LN=Lymphnodes.…”

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confidence: 74%

Prognostic Factors and Survival in Stomach Cancer – Analysis of 15 Years of Data from a Referral Hospital in Iran and Evaluation of International Variation

et al. 2011

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Background: Stomach cancer is the most common cancer among Iranian men. We studied survival rates and prognostic factors of stomach cancer in a referral hospital in Tehran, Iran. Patients and Methods: We followed 367 stomach cancer patients hospitalized between 1991 and 2007 in the Baqyiatallah Hospital. We estimated survival rates overall and among operable patients exclusively. Hazard ratios (HR) for the different prognostic factors were estimated with the Cox regression model. Furthermore, we studied international variations in stage distribution and 5year survival for stomach cancer. Results: Overall, 5year survival of stomach cancer was low (14%), and the majority of patients (53%) were diagnosed at stage IV. Stage, tumor size, age, and gender were statistically significant prognostic factors. Relative risk of mortality in stage IV compared to stage IA was 9.9 (95% confidence interval 5.8–16.9). The highest 5year survival was reported from Japan, particularly among screening detected patients (89.4%). Among operable patients, 5year survival was 32.6% in France, 26% in the USA, and 30.5% in China, which was close to the rates estimated in our study (24%). Conclusions: Due to stomach cancer being frequently diagnosed in advanced stages, its prognosis is poor in Iran. Early diagnosis and downstaging strategies need to be prioritized to improve the prognosis of stomach cancer.

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confidence: 74%

Prognostic Factors and Survival in Stomach Cancer – Analysis of 15 Years of Data from a Referral Hospital in Iran and Evaluation of International Variation

et al. 2011

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“…In the United States, 12,100 deaths from gastric cancer were expected during 2003 with a death rate of 6.8 per 100,000 (3). The overall age-adjusted incidence (world population) of gastric cancer in Jordan is 5.82 per 100,000 per year (4). The risk of developing gastric cancer is relatively lower in the Middle East and North Africa compared with those of western countries and Japan (1,4).…”

Section: Introductionmentioning

confidence: 99%

“…The overall age-adjusted incidence (world population) of gastric cancer in Jordan is 5.82 per 100,000 per year (4). The risk of developing gastric cancer is relatively lower in the Middle East and North Africa compared with those of western countries and Japan (1,4). Environmental factors such as Helicobacter pylori and dietary factors play an important role in gastric carcinogenesis (5,6).…”

Section: Introductionmentioning

confidence: 99%

Combined Evaluation of Expressions of Cyclin E and p53 Proteins as Prognostic Factors for Patients with Gastric Cancer

Bani-Hani¹,

Almasri²,

Khader³

et al. 2005

Clinical Cancer Research

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Background: There is a lack of consistency regarding the prognostic value of cyclin E overexpression in gastric cancer (GC). Our aim was to report on this overexpression and to analyze its correlations with the clinicopathologic variables. Another aim was to examine if aberrant expression of both cyclin E and p53 might increase the malignant potential of gastric cancer.Methods: Specimens from 89 patients with gastric cancer treated with ''curative'' intent were evaluated for cyclin E and p53 expressions using immunohistochemical method. The correlations between cyclin E overexpression alone or in combination with p53 expression and the patient's clinicopathologic variables were analyzed.Results: Cyclin E overexpression and p53 expression were shown in 35 (39.3%) and 46 (51.7%) tumors, respectively. The incidence of cyclin E overexpression was significantly higher in deeply invasive cancers (P < 0.0001), in cancers with lymph node metastasis (P = 0.003), and in cancers with advanced stages (P < 0.0001). There were no significant correlations with other clinicopathologic variables. Patients in whom their tumors showed cyclin E overexpression alone or in combination with p53 survived less than patients with negative cyclin E tumors. Multivariate analysis revealed that combined cyclin E overexpression and p53 expression was significantly associated with poor survival after adjusting for other variables (hazard ratio, 3.12; P = 0.009).Conclusions: Cyclin E overexpression is a common event in gastric cancer. Gastric cancer with cyclin E overexpression exhibit increased aggressiveness in the presence of aberrant p53. The combination of cyclin E

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“…In the United States, 12 100 deaths from gastric cancer were expected during 2003 with a death rate of 6.8 per 100 000 [4] . The overall age-adjusted incidence (world population) of gastric cancer in Jordan is 5.8 per 100 000 [5] . The burden of new cancer cases has been estimated in the year 2002 based on the National Cancer Registry Programme in India.…”

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confidence: 99%

Correlation of p53 over-expression and alteration in p53 gene detected by polymerase chain reaction-single strand conformation polymorphism in adenocarcinoma of gastric cancer patients from India

Karim¹,

Ali²

2009

WJG

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AIM:To study the alterations in p53 gene among Indian gastric cancer patients and to correlate them with the various clinicopathological parameters. METHODS:A total of 103 gastric cancer patients were included in this study. The p53 alterations were studied by both immunohistochemical method as well as polymerase chain reaction (PCR)-single strand conformation polymorphism (SSCP) analysis. We only studied four (exon 5, 6, 7, and 8) of the 11 p53 exons. The alterations in p53 were also correlated with respect to various clinicopathological parameters. RESULTS:Among 103 cases, p53 over-expression and alteration were detected in 37 (35.92%) and 19 (18.44%) cases, respectively. Most of the p53 alterations were found at exon 5 (31.54%), followed by exon 6 (26.31%), exon 7 (21.04%) and exon 8 (21.04%). A significant correlation of p53 overexpression was found with p53 alteration (P = 0.000). Concordance between p53 alteration (as detected by SSCP) and over-expression [as detected by immunohistochemistry (IHC)] was found in 75% cases. We found that IHC-positive/SSCP-negative cases accounted for 21% of cases and IHC-negative/SSCPpositive cases accounted for remaining 4% cases. CONCLUSION:Our results show that p53 gene mutations are significantly correlated with p53 protein over-expression, with 75% concordance in overexpression and alteration in the p53 gene, but 25% disconcordance also cautions against the assumption that p53 over-expression is always associated with a gene mutation. There may be other mechanisms responsible for stabilization and accumulation of p53 protein with no evidence of gene mutation that reflect an accumulation of a non-mutated protein, or a false negative SSCP result.

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Gastric malignancies in Northern Jordan with special emphasis on descriptive epidemiology

Cited by 23 publications

References 22 publications

Prognostic Factors and Survival in Stomach Cancer – Analysis of 15 Years of Data from a Referral Hospital in Iran and Evaluation of International Variation

Prognostic Factors and Survival in Stomach Cancer – Analysis of 15 Years of Data from a Referral Hospital in Iran and Evaluation of International Variation

Combined Evaluation of Expressions of Cyclin E and p53 Proteins as Prognostic Factors for Patients with Gastric Cancer

Correlation of p53 over-expression and alteration in p53 gene detected by polymerase chain reaction-single strand conformation polymorphism in adenocarcinoma of gastric cancer patients from India

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