2011
DOI: 10.4321/s1130-01082011001200014
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Gastric metastasis from renal cancer six years after nephrectomy

Abstract: Renal cell carcinoma is the third most common urogenital neoplasia (1). The lung and bone tissues represent the most frequent metastatic sites of renal cell carcinoma (2). Metastases in the stomach are rare and have been essentially described during autopsies (3). In this paper, we present a case of large metastatic gastric tumor whose origin was a renal cell carcinoma treated years ago. Case reportA 56 year old woman was diagnosed with stage one renal adenocarcinoma 6 years ago. She was treated with right rad… Show more

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Cited by 7 publications
(5 citation statements)
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“…He had a personal history of left radical nephrectomy for clear cell renal cell carcinoma (G3, Primary neoplasms most commonly metastasizing to the stomach include breast cancer, lung cancer, and melanoma (1), with renal cell carcinoma being certainly rare (2), involving highly variable presentations that range from early to extremely late onsets (3). Today's higher rate of digestive endoscopy procedures and routine studies has increased the diagnosis of this condition (4,5); however, histology and immunohistochemistry studies with specific markers (positive CK AE1/AE3, CD10, PAX8, vimentin, and renal cell carcinoma antigens in our case) are key for a definitive diagnosis of metastatic gastric lesions, as pointed out by Adolfo Cruz et al (5). The lesion's atypical gross appearance for a primary gastric carcinoma and the patient's positive cancer history, even with such a delayed onset, should prompt consideration of this potential condition in the differential diagnosis.…”
Section: Dear Editormentioning
confidence: 81%
“…He had a personal history of left radical nephrectomy for clear cell renal cell carcinoma (G3, Primary neoplasms most commonly metastasizing to the stomach include breast cancer, lung cancer, and melanoma (1), with renal cell carcinoma being certainly rare (2), involving highly variable presentations that range from early to extremely late onsets (3). Today's higher rate of digestive endoscopy procedures and routine studies has increased the diagnosis of this condition (4,5); however, histology and immunohistochemistry studies with specific markers (positive CK AE1/AE3, CD10, PAX8, vimentin, and renal cell carcinoma antigens in our case) are key for a definitive diagnosis of metastatic gastric lesions, as pointed out by Adolfo Cruz et al (5). The lesion's atypical gross appearance for a primary gastric carcinoma and the patient's positive cancer history, even with such a delayed onset, should prompt consideration of this potential condition in the differential diagnosis.…”
Section: Dear Editormentioning
confidence: 81%
“…Apart from these endoscopic resection/excision, systemic chemotherapy are used for the treatment of gastric metastases. [2,12] Our patient declined these treatments, and he is still under our control. In a recently published article achievement of complete remission was reported during 24 months of follow-up after radiotherapy, and pazopanib treatment.…”
Section: Discussionmentioning
confidence: 99%
“…[5] In the English literature, in 50 cases with renal cell carcinomas, gastric metastases were reported. [1][2][3][4][5][6][7][8][9][10][11][12] Median age of the cases was 66.5 (38-87) years. As is seen in our case, it is more frequently detected in men.…”
Section: Discussionmentioning
confidence: 99%
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