Gastric metastatic extension of invasive ductal carcinoma of the breast with atypical endoscopic presentation

Mata, Claudia de Zárraga; Salom, Guiem Thomás; Martorell, Angels Vilella; Ramonell, Francisca Salvà; Oliver, Ángela Laura Maura; Abadía, Carlos Dolz

doi:10.1016/j.gastre.2018.05.002

Cited by 1 publication

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“…Breast IDC metastases to the liver, lung and brain are more common. Breast IDC metastases to the gastrointestinal tract are extremely rare [4]. Breast IDC with neuroendocrine differentiation is a rare subtype of breast cancer.…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological characteristics of neuroendocrine differentiated invasive breast cancer with simultaneous gastric, colon and lung metastases: a case report

Wang¹,

Chen²,

Liao³

et al. 2022

Preprint

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Background: To investigate the clinicopathological characteristics of infiltrating ductal carcinoma of the breast with neuroendocrine differentiation and metastasis to the stomach, colon and lung at the same time. Methods: To The histopathological characteristics and immunophenotype of a case of breast invasive ductal carcinoma with neuroendocrine characteristics and concurrent gastric, colon and lung metastases were observed. Results: The histological structure and cell morphology of the primary lesions and metastatic lesions of breast invasive ductal carcinoma with neuroendocrine differentiation were basically the same, and they were all non-lumen invasive ductal carcinoma of the breast. The antibody markers of this case of breast invasive ductal carcinoma were as follows: the primary and metastatic foci were all positive for E-cad, p120 and ER, while PR, HER2, GATA3, Mammaglobin and GCDFP-15 were all negative. The antibody markers of non-breast tissues were as follows: TTF1, CgA and Sym were positively expressed in primary and metastatic foci. This tumour was extremely rare and had characteristic histomorphological changes. Conclusion: The diagnosis of invasive breast carcinoma with neuroendocrine differentiation should be based on histology and cell morphology, CgA and SyN-positive expression, mitosis and cell proliferation index ki-67 positive cell comprehensive analysis, in order to improve understanding and early diagnosis and avoid missed diagnosis and misdiagnosed cases.

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Section: Introductionmentioning

confidence: 99%