Gastric microbiota in gastric cancer: Different roles of Helicobacter pylori and other microbes

Guo, Yang; Cao, Xueshan; Zhou, Ming-Sheng; Yu, Bo

doi:10.3389/fcimb.2022.1105811

Cited by 21 publications

(13 citation statements)

References 64 publications

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“…It will be a further point of interest to understand the role of bacteria carried in the saliva and transiting the stomach and whether, in the absence of H. pylori, some of them become candidates for resilience and explain the entity of H. pylori-negative gastritis. The contributing role of bacteria in the development of severe gastritis into gastric cancer is shown in animal experiments and humans, and more insights are expected in this area 161,368,369 . Vaccine development should be pursued and lessons from previous failures will help in new approaches 172 .…”

Section: Discussionmentioning

confidence: 99%

Helicobacter pylori infection

Malfertheiner

Camargo

El-Omar

et al. 2023

Nat Rev Dis Primers

317

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Helicobacter pylori infection causes chronic gastritis, which can progress to severe gastroduodenal pathologies, including peptic ulcer, gastric cancer and gastric mucosa-associated lymphoid tissue lymphoma. H. pylori is usually transmitted in childhood and persists for life if untreated. The infection affects around half of the population in the world but prevalence varies according to location and sanitation standards. H. pylori has unique properties to colonize gastric epithelium in an acidic environment. The pathophysiology of H. pylori infection is dependent on complex bacterial virulence mechanisms and their interaction with the host immune system and environmental factors, resulting in distinct gastritis phenotypes that determine possible progression to different gastroduodenal pathologies. The causative role of H. pylori infection in gastric cancer development presents the opportunity for preventive screen-and-treat strategies. Invasive, endoscopy-based and non-invasive methods, including breath, stool and serological tests, are used in the diagnosis of H. pylori infection. Their use depends on the specific individual patient history and local availability. H. pylori treatment consists of a strong acid suppressant in various combinations with antibiotics and/or bismuth. The dramatic increase in resistance to key antibiotics used in H. pylori eradication demands antibiotic susceptibility testing, surveillance of resistance and antibiotic stewardship.

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Section: Discussionmentioning

confidence: 99%

Helicobacter pylori infection

Malfertheiner

Camargo

El-Omar

et al. 2023

Nat Rev Dis Primers

317

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“…In recent decades, increasing evidence has demonstrated that gut microbiota plays an essential role in health and disease ( Stewart et al, 2020 ; Guo et al, 2023 ). Studies have shown that the gut microbiota is associated with radiotherapy for colorectal cancer 11-13 .…”

Section: Discussionmentioning

confidence: 99%

The relationship between gastric microbiome features and responses to neoadjuvant chemotherapy in gastric cancer

Zhang,

Xu,

Zhou

2024

Front. Microbiol.

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BackgroundEmerging evidence demonstrates that the gastrointestinal microbiome has the potential to be a biomarker in neoadjuvant chemoradiotherapy for colorectal cancer (CRC). Yet studies on the impact of the gastric microbiome (GM) on the response to neoadjuvant chemotherapy (NACT) are still scarce.MethodsForty-eight patients with gastric cancer participated in this retrospective study, and 16S rRNA sequencing was performed to evaluate formalin-fixed and paraffin-embedded (FFPE) tissue biospecimens and fresh-frozen tissues.ResultsIn this study, 16 bacterial taxa at different levels, including Bacillus, Anaerococcus, and Chloroflexi, were identified to be enriched before NACT in response (R) patients in group FFPE. In contrast, 6 bacterial taxa, such as Haemophilus, Veillonellaceae (Veillonella), etc. were enriched after NACT, in which we reported for the first time that the phylum Chloroflexi was enriched before NACT in R patients. Thirty-one bacterial taxa of Coriobacteriaceae, Ruminococcaceae, Veillonellaceae, and Lachnospiraceae were identified in group mucosa as being enriched in R patients. In comparison, 4 bacterial taxa dominated by the phylum Proteobacteria were enriched in NR patients. Notably, the family Veillonellaceae was found in both tissue samples, and the metabolic pathways, including the citrate cycle (TCA cycle) and various amino acids, including alanine, were found to be potentially predictive in both sample species.ConclusionThere are differences in the features of the GM for different NACT response results. The causal relationship deserves to be confirmed by further investigations.

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“…As H. pylori is a bacterium that affects and is affected by the gastric microbiota, it is closely related to other bacteria in the progression of GC. Non- H. pylori microorganisms interact with H. pylori in gastric carcinogenesis ( Guo et al, 2023 ). Successful H. pylori eradication can reverse gastric microbiota dysbiosis ( Guo et al, 2020 ; Guo Q. et al, 2022 ), and its high eradication rate is related to specific flora members ( Niu et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Global status and trends of gastric cancer and gastric microbiota research: a bibliometric analysis

Ke,

Tan,

Zhen

et al. 2024

Front. Microbiol.

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BackgroundNumerous studies have cast light on the relationship between the gastric microbiota and gastric carcinogenesis. In this study, we conducted a bibliometric analysis of the relevant literature in the field of gastric cancer and the gastric microbiota and clarified its research status, hotspots, and development trends.Materials and methodsPublications were retrieved from the Web of Science Core Collection on 18 July 2023. CiteSpace 6.2.R4, VOSviewer 1.6.19.0, and Biblioshiny were used for the co-occurrence and cooperation analyses of countries, institutions, authors, references, and keywords. A keyword cluster analysis and an emergence analysis were performed, and relevant knowledge maps were drawn.ResultsThe number of published papers in this field totaled 215 and showed an increasing trend. The analysis of funding suggested that the input in this field is increasing steadily. China had the highest number of publications, while the United States had the highest betweenness centrality. Baylor College of Medicine published the most articles cumulatively. Both Ferreira RM and Cooker OO had the highest citation frequency. The journal Helicobacter showed the most interest in this field, while Gut provided a substantial research foundation. A total of 280 keywords were obtained using CiteSpace, which were primarily focused on the eradication and pathogenic mechanisms of Helicobacter pylori, as well as the application of the gastric microbiota in the evaluation and treatment of gastric cancer. The burst analysis suggested that in the future, research may focus on the application of gastric microorganisms, particularly Fusobacterium nucleatum, in the diagnosis and treatment of gastric cancer, along with their pathogenic mechanisms.ConclusionCurrent studies have been tracking the eradication of Helicobacter pylori and its pathogenic mechanisms, as well as changes in the gastric microbiota during gastric carcinogenesis. Future research may focus on the clinical application and pathogenesis of stomach microorganisms through bacteria such as Fusobacterium nucleatum.

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Gastric microbiota in gastric cancer: Different roles of Helicobacter pylori and other microbes

Cited by 21 publications

References 64 publications

Helicobacter pylori infection

Helicobacter pylori infection

The relationship between gastric microbiome features and responses to neoadjuvant chemotherapy in gastric cancer

Global status and trends of gastric cancer and gastric microbiota research: a bibliometric analysis

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