Gastric Motility Disorders in Dogs and Cats

Husník, Roman; Gaschen, Frédéric

doi:10.1016/j.cvsm.2020.09.002

Cited by 12 publications

(16 citation statements)

References 47 publications

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“… 1 , 2 Clinical signs associated with GD are nonspecific and include nausea, inappetence, abdominal discomfort, regurgitation, and vomiting. 1 , 2 They might be difficult to differentiate from those of concurrent illness, stress, or other confounding factors. In addition, standard methods of assessing gastric motility are often labor intensive, invasive, and thus impractical in the veterinary hospital setting.…”

Section: Introductionmentioning

confidence: 99%

“… 2 These factors can complicate recognition and delay treatment of GD which adversely affects cats by prolonging hospitalization and impeding recovery. 1 , 2 …”

Section: Introductionmentioning

confidence: 99%

“…Gastric dysmotility (GD) can complicate gastrointestinal (GI) and other illnesses encountered in cats. 1,2 Clinical signs associated with GD are nonspecific and include nausea, inappetence, abdominal discomfort, regurgitation, and vomiting. 1,2 They might be difficult to differentiate from those of concurrent illness, stress, or other confounding factors.…”

Section: Introductionmentioning

confidence: 99%

“…2 These factors can complicate recognition and delay treatment of GD which adversely affects cats by prolonging hospitalization and impeding recovery. 1,2 At present, treatment options for GI motility disorders are limited. 2 This is due to the sparse number of prokinetic drugs available, as well as the logistical challenges associated with the acquisition and administration of some of those drugs.…”

Section: Introductionmentioning

confidence: 99%

“…1,2 At present, treatment options for GI motility disorders are limited. 2 This is due to the sparse number of prokinetic drugs available, as well as the logistical challenges associated with the acquisition and administration of some of those drugs. In addition, limitations associated with measuring GI motility have resulted in failure to accurately assess the efficacy of prokinetics.…”

Section: Introductionmentioning

confidence: 99%

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Ultrasonographic evaluation of the effects of azithromycin on antral motility and gastric emptying in healthy cats

Rutherford

Gaschen

Husník

et al. 2022

Veterinary Internal Medicne

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Background Erythromycin, a macrolide antibiotic with motilin agonist properties, shortens gastric emptying (GE) time in healthy cats. Azithromycin, another macrolide antibiotic, is effective for treatment of gastric paresis in people. Objectives To evaluate the effects of azithromycin on GE and gastric motility in healthy cats in comparison with erythromycin (positive control) and placebo. Animals Eight healthy purpose‐bred cats. Methods Prospective, blinded, crossover study. Cats received either azithromycin (3.5 mg/kg PO q24h), erythromycin (1 mg/kg PO q8h), or placebo for 24 hours before and during evaluation of GE. A validated method using ultrasound for sequential measurements of antral area as well as amplitude and frequency of contractions was used to assess GE and evaluate gastric antral motility postprandially over an 8‐hour period. Results GE was significantly faster (P < .05) after administration of azithromycin and erythromycin when compared to placebo in the late phase of fractional emptying from 75% (mean ± SD: 327 ± 51 minutes, 327 ± 22 minutes, and 367 ± 29 minutes, respectively), to 95% fractional emptying (399 ± 52 minutes, 404 ± 11 minutes, and 444 ± 24 minutes, respectively). The drugs had no significant effect on antral motility variables at any time point. Conclusions and Clinical Importance Azithromycin and erythromycin shorten GE time in a comparable manner in healthy cats. Evaluation of their efficacy in cats with gastric dysmotility is warranted.

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Section: Introductionmentioning

confidence: 99%

“… 2 These factors can complicate recognition and delay treatment of GD which adversely affects cats by prolonging hospitalization and impeding recovery. 1 , 2 …”

Section: Introductionmentioning

confidence: 99%