Gastric Mucosa-Associated Lymphoid Tissue Lymphoma

Ahmad, Asyia S.; Govil, Yogesh; Frank, Barbara

doi:10.1111/j.1572-0241.2003.07424.x

Cited by 125 publications

(81 citation statements)

References 80 publications

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“…However, primary gastric lymphoma is the most common extranodal lymphoma (1)(2)(3)(4)(5). Histological features of gastric low-grade lymphomas closely resemble mucosa-associated lymphoid tissue (MALT) (1)(2)(3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

“…Some studies showed that the prevalence of infection depends on the lymphoma's histological grade or the diagnostic method used, among others (8). A knowledge of the true prevalence of H. pylori in patients with MALT lymphoma is clinically relevant, as the detection of this organism will be followed by adequate eradication treatment, with consequent tumor regression in a high number of cases (1)(2)(3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

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Gastric MALT lymphoma: clinical characteristics and prevalence of H. pylori infection in a series of 37 cases

Gisbert

Aguado

Luna

et al. 2006

Rev. esp. enferm. dig.

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Objective: to perform a retrospective review of the clinical characteristics and prevalence of H. pylori infection in patients with gastric MALT lymphoma diagnosed in our hospital during the last 15 years.Methods: patients with gastric MALT lymphoma diagnosed in our hospital during the last 15 years were retrospectively included. Demographic, clinic, analytic, endoscopic, and histological variables were reviewed. The extension study, the staging classification, and the presence of H. pylori infection were assessed.Results: thirty-seven patients with gastric MALT lymphoma were identified. Mean age was 61 years, with 62% of males. The most common presentation symptom was dyspepsia (76%), followed by digestive bleeding (11%) and constitutional syndrome (8%). At endoscopy, erosive lesions were identified in 41%, and proliferative or exophytic lesions in 43%. Most lymphomas were classified as low-grade (68%). The stage distribution was EI for 56%, EII for 13%, EIII for 3%, and EIV for 28%. The prevalence of H. pylori infection (histology in all cases, rapid urease test in 19%, and 13 C-urea breath test in 24%) was 46%. When only lowgrade lymphomas in stage EI were considered, H. pylori prevalence increased to 55%. When H. pylori infection was evaluated by 13 C-urea breath testing (in addition to histology), the prevalence of H. pylori infection increased to 78%.Conclusions: it is probable that the reduced H. pylori prevalence found in some studies, as in ours, could be explained by false-negative results obtained when only one diagnostic method was used. Therefore, at least two (invasive) diagnostic methods should be performed. Furthermore, the performance of a non-invasive diagnostic method (such as a 13 C-urea breath test) before the exclusion of H. pylori infection should be considered.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Gastric MALT lymphoma: clinical characteristics and prevalence of H. pylori infection in a series of 37 cases

Gisbert

Aguado

Luna

et al. 2006

Rev. esp. enferm. dig.

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“…Since the successful isolation of Helicobacter pylori in 1984 by Marshall and Warren (19), H. pylori infection has been recognized to have a causal role in peptic ulcer disease and a strong association with gastric carcinoma (1,8). H. pylori characteristically displays a great genetic variability due to a high rate of spontaneous mutations and genetic recombination (6,9,23).…”

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confidence: 99%

Pathogen Evolution In Vivo: Genome Dynamics of Two Isolates Obtained 9 Years Apart from a Duodenal Ulcer Patient Infected with a Single Helicobacter pylori Strain

et al. 2005

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The survival and microevolution of Helicobacter pylori strains in the niches of the stomach after eradication therapy have largely been unexplored. We analyzed genomic signatures for two successive isolates obtained 9 years apart from a duodenal ulcer patient who underwent eradication therapy for H. pylori. These isolates were genotyped based on 50 different parameters involving three different fingerprinting approaches and several evolutionarily significant and virulence-associated landmarks in the genome, including nine informative gene loci, the cag pathogenicity island and its right junction, members of the plasticity region cluster, and vacA and iceA alleles. Our observations reveal that the two isolates were derived from the same strain that colonized the patient for almost a decade and were almost identical. Microevolution, however, was observed in the cagA gene and its right junction, the vacA m1 allele, and a member of the plasticity region cluster (JHP926). These results suggest that H. pylori has a great ability to survive and reemerge as a microevolved strain posteradication, thereby hinting at the requirement for follow-up of patients after therapy.

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“…Once acquired, H. pylori may persist throughout the life of the human host in the absence of appropriate antibiotic treatment. Persistent H. pylori colonization can lead to the development of peptic ulcers, gastritis, mucosa-associated lymphoid tissue, lymphoma, and gastric cancer (1,11). Current first-line eradication therapies involve a proton pump inhibitor or ranitidine bismuth citrate and two antibiotics, clarithromycin and either amoxicillin or metronidazole.…”

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confidence: 99%

16S rRNA Mutations That Confer Tetracycline Resistance inHelicobacter pyloriDecrease Drug Binding inEscherichia coliRibosomes

Nonaka¹,

Connell

Taylor

2005

J Bacteriol

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Tetracycline resistance in clinical isolates of Helicobacter pylori has been associated with nucleotide substitutions at positions 965 to 967 in the 16S rRNA. We constructed mutants which had different sequences at 965 to 967 in the 16S rRNA gene present on a multicopy plasmid in Escherichia coli strain TA527, in which all seven rrn genes were deleted. The MICs for tetracycline of all mutants having single, double, or triple substitutions at the 965 to 967 region that were previously found in highly resistant H. pylori isolates were higher than that of the mutant exhibiting the wild-type sequence of tetracycline-susceptible H. pylori. The MIC of the mutant with the 965TTC967 triple substitution was 32 times higher than that of the E. coli mutant with the 965AGA967 substitution present in wild-type H. pylori. The ribosomes extracted from the tetracycline-resistant E. coli 965TTC967 variant bound less tetracycline than E. coli with the wild-type H. pylori sequence at this region. The concentration of tetracycline bound to the ribosome was 40% that of the wild type. The results of this study suggest that tetracycline binding to the primary binding site (Tet-1) of the ribosome at positions 965 to 967 is influenced by its sequence patterns, which form the primary binding site for tetracycline.

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Gastric Mucosa-Associated Lymphoid Tissue Lymphoma

Cited by 125 publications

References 80 publications

Gastric MALT lymphoma: clinical characteristics and prevalence of H. pylori infection in a series of 37 cases

Gastric MALT lymphoma: clinical characteristics and prevalence of H. pylori infection in a series of 37 cases

Pathogen Evolution In Vivo: Genome Dynamics of Two Isolates Obtained 9 Years Apart from a Duodenal Ulcer Patient Infected with a Single Helicobacter pylori Strain

16S rRNA Mutations That Confer Tetracycline Resistance inHelicobacter pyloriDecrease Drug Binding inEscherichia coliRibosomes

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