Gastric mucosal calcinosis

Hsieh, Ting Hui; McCullough, Ann; Aqel, Bashar

doi:10.1016/j.gie.2011.01.029

Cited by 8 publications

(9 citation statements)

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“…Iatrogenic calcification occurs secondary to pharmacotherapeutic intervention (i.e., sucralfate or calcium therapy). Idiopathic calcification occurs in normal tissues without hypercalcemia or hyperphosphatemia [ 1 , 5 ]. Rarely, gastric MC has been reported without an associated condition in which case it may be considered idiopathic in etiology [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…Rarely, gastric MC has been reported without an associated condition in which case it may be considered idiopathic in etiology [ 7 ]. MC may be secondary to multiple factors including renal transplantation, sucralfate therapy, an elevated calcium-phosphorus product, and/or dystrophic calcification in inflamed/eroded mucosa [ 1 – 5 ]. All of the reported cases of esophageal MC, including our case, have been in patients with end stage renal disease and it seems that the most important etiologic factor in these cases was hypercalcemia or hyperphosphatemia in renal disease (i.e., metastatic calcification) [ 4 – 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…The endoscopic findings range from plaque-like areas to nodules and/or ulceration, similar to our case which demonstrated diffuse white plaque-like areas and ulceration [ 4 – 6 ]. Endoscopically, these deposits may resemble candidiasis or eosinophilic abscesses [ 1 ]. Histologically, there are basophilic intraepithelial deposits of calcium within the squamous mucosa often associated with erosions/ulcerated mucosa.…”

Section: Discussionmentioning

confidence: 99%

“…When mucosal calcinosis (MC) occurs in the gastrointestinal tract it most commonly affects the gastric mucosa, while esophageal involvement is rare [ 1 – 7 ]. There are numerous associated conditions identified for gastric MC including solid organ transplantation, use of aluminum-containing antacids or sucralfate, malignancy, and chronic renal failure.…”

Section: Introductionmentioning

confidence: 99%

“…There are numerous associated conditions identified for gastric MC including solid organ transplantation, use of aluminum-containing antacids or sucralfate, malignancy, and chronic renal failure. Rarely some cases of gastric MC may be idiopathic in etiology [ 1 – 7 ]. The reported cases of esophageal MC have been in patients with similar associated conditions, especially end stage renal disease which was present in all 3 previously reported cases [ 4 – 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Esophageal Mucosal Calcinosis: A Rare Site of Gastrointestinal Mucosal Calcinosis

et al. 2018

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Patient: Male, 68Final Diagnosis: Esophageal mucosal calcinosisSymptoms: DysphagiaMedication: —Clinical Procedure: EsophagogastroduodenoscopySpecialty: Gastroenterology and HepatologyObjective:Rare co-existance of disease or pathologyBackground:Gastrointestinal tract mucosal calcinosis (MC) tends to affect the gastric mucosa, while esophageal involvement is rare. Gastric MC may be seen with solid organ transplantation, use of aluminum-containing antacids or sucralfate, malignancy, and chronic renal failure. While the incidence of gastric MC in renal transplant patients undergoing gastric biopsy is common (between 15–29%), to our knowledge esophageal MC has only been previously reported 3 times.Case Report:A 68-year-old male dialysis-dependent end stage renal disease status-post deceased donor kidney transplant underwent an esophagogastroduodenoscopy (EGD) for dysphagia and diffuse esophageal wall thickening seen on imaging studies. EGD demonstrated diffuse, circumferential thick white esophageal plaques and mucosal friability. Esophageal biopsies demonstrated erosive esophagitis with basophilic calcium deposits within the fibrinopurulent exudate and squamous mucosa. Stains for fungal organisms and viruses were negative. A diagnosis of esophageal MC was made. Although the patient had a protracted postoperative course after transplantation, he had improvement of the esophageal wall thickening on imaging after transplantation.Conclusions:Esophageal MC is a rare phenomenon and all of the previously reported cases of esophageal MC, including our case, have been in patients with end stage renal disease who were on dialysis. Although prolonged hypercalcemia and hyperphosphatemia, an elevated calcium-phosphorus product, and associated underlying inflammation are likely key etiologic factors, the pathogenesis of esophageal MC is not fully understood and is likely due to multiple collective etiologies. Likewise, more reported cases are likely to increase our understanding of the clinical significance and management of this rare disorder.

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Section: Discussionmentioning

confidence: 99%