Gastric Mucosal Damage Evaluated by Transnasal Endoscopy and QOL Assessments in Ischemic Heart Disease Patients Receiving Low-dose Aspirin

Abstract

Objective Transnasal endoscopy was conducted to examine gastric mucosal damage in Japanese patients with ischemic heart disease who were receiving low-dose aspirin for preventing the onset or recurrence of cardiovascular disease. Patients and Methods An endoscopist assessed gastric mucosal damage. Furthermore, the MOS 36-Item Short-Form Health Survey (SF-36 ) and the Gastrointestinal Symptom-Rating Scale (GSRS) were used to assess the outcomes of their quality of life (QOL) and the possible presence of gastric cancer and H. pylori infection. Results Seventy-five patients were studied; and 24 (32.0%) and 16 (21.3%) of them concurrently received antithrombotic drugs other than aspirin and antiulcer drugs, respectively. Regarding gastric mucosal damage, 15 (20.0%) and 8 (10.7%) of the patients were endoscopically diagnosed with ulcer and hemorrhagic gastritis, respectively. Furthermore, 5 patients (6.7%) were found to have esophageal or gastric cancer. The positivity rate of Helicobacter pylori (H. pylori) was 45.3%. Patients receiving low-dose aspirin showed a decreased QOL. Consequently, no significant differences were found among the groups. Regarding endoscopic findings, no differences were found in the scores of both SF-36 and GSRS with respect to the presence or absence of gastric ulcer, hemorrhagic gastritis, and H. pylori infection. Conclusion Transnasal endoscopy was possible to perform during the oral intake of low-dose aspirin without causing any hemorrhagic complications. Many patients with gastric mucosal lesions showed no subjective symptom, and patients receiving aspirin were strongly recommended to undergo regular transnasal endoscopy, regardless of the presence or absence of symptoms.

410 Upper Gastrointestinal Mucosal Injury and Symptoms in Elderly Low-Dose Aspirin Users

“…However, in our study, no significant differences were found between patients with gastric ulcer or those who did not take aspirin [50,51]. Among patients with DI, LDA users had significantly lower MCS than nonusers.…”

Upper Gastrointestinal Mucosal Injury and Symptoms in Elderly Low-Dose Aspirin Users

“…It is known that patients with peptic ulcer have lower QOL than healthy people and that patients taking aspirin experience decreased QOL. However, in our study, no significant differences were found between patients with gastric ulcer or those who did not take aspirin [ 50 , 51 ]. Among patients with DI, LDA users had significantly lower MCS than nonusers.…”

Effect of low-dose aspirin on upper gastrointestinal tract mucosa

“…Other studies did not detect such an association, reporting that the presence or absence of H. pylori infection was not associated with the incidence of gastric ulcer in NSAIDs users [14]. Other studies did not detect such an association, reporting that the presence or absence of H. pylori infection was not associated with the incidence of gastric ulcer in NSAIDs users [14].…”