Gastric Mucosal Dysplasia: What is its Clinical Significance?

Oehlert, W.; Keller, Peter M.; Henke, M; Strauch, M

doi:10.1159/000402299

Cited by 58 publications

(14 citation statements)

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“…The World Health Organization defines adenomatous polyps of the stomach as noninvasive intramucosal neoplasia (36,37). Typically, adenomatous polyps grow from atrophic gastric mucosa, and high-grade dysplasia is identified in close association with a high proportion (40%-100%) of early gastric cancers (38). High-grade dysplasia is considered to be a direct precursor to invasive gastric cancer and is regarded as a malignancy by some pathologists (39).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of gastric polyps detected by endoscopy: A single-center study of a four-year experience in Turkey

Atalay

Solakoğlu²,

Sarı³

et al. 2020

Turk J Gastroenterol

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Background/Aims: The aim of this study was to evaluate the gastric polyps detected by endoscopy in our institution with respect to their frequency, size, anatomic location, presence of dysplasia, and histopathologic features. Materials and Methods: Records of a total of 14,240 patients who underwent endoscopy between January 2008 and January 2012 were reviewed retrospectively. Of the 14,240 patients, 174 determined to have at least 1 histopathologically proven polyp were included in the study. Results: Three hundred eleven gastric polyps were found in 174/14,240 (1.2%) patients (1.79 polyps per patient). Gastric polyps were found most commonly in the antrum (41.5%). Of all gastric polyps, 189 (60.8%) were less than 1 cm. Histopathologically, the most common polyp type was hyperplastic (n: 261, 83.9%), followed by adenomatous (n: 23, 7.4%). Eight (34.8%) of the adenomatous polyps showed dysplasia, and in 4 (17.4%) of these cases, the dysplasia was high-grade. Nineteen (6.1%) of all gastric polyps were identified to be fundic gland polyps. Conclusion: According to this study from Turkey, the majority of polyps detected by endoscopy was solitary, smaller than 1 cm, and found in the antrum; furthermore, the most common type was a hyperplastic polyp.

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Section: Discussionmentioning

confidence: 99%

Evaluation of gastric polyps detected by endoscopy: A single-center study of a four-year experience in Turkey

Atalay

Solakoğlu²,

Sarı³

et al. 2020

Turk J Gastroenterol

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“…Screening by endoscopy and biopsy is readily available but more studies are re quired to determine if this is worthwhile. Even if severe dysplasia is found at biopsy [88,107], a conservative approach seems in dicated as this can regress [108]. As gastric cancer is declining and as the prevalence is low in Western countries [109], mass screen ing even for high risk patients seems inap propriate [110].…”

Section: Screening For Gastric Cancermentioning

confidence: 99%

Chronic (Nonerosive) Gastritis: Pathogenesis and Management

Talley

1989

Dig Dis

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“…Therefore, there is currently no specific treatment policy for GEDs, and the treatments vary from close endoscopic follow-up to endoscopic resection. However, GEDs have been previously demonstrated to represent a penultimate state of gastric carcinogenesis, and to be indicators of an increased risk of synchronous adenocarcinoma elsewhere in the stomach [9][10][11]. On the basis of these data, endoscopic resection has been recently recommended as the standard treatment for GEDs after prior histologic confirmation of dysplasia [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Gastric epithelial dysplasia: Characteristics and long-term follow-up results after endoscopic resection according to morphological categorization.

Lee

Kim

Baek

2015

JCO

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Background: Gastric epithelial dysplasia (GED) can be morphologically categorized into adenomatous and foveolar types. To date, there have been few studies on the clinical characteristics of GEDs according to the morphologic types. Therefore, we here aimed to elucidate the clinicopathologic characteristics of patients with GED and the long-term follow-up results after endoscopic resection according to the morphologic characteristics of GEDs. Methods: A total of 357 patients who underwent endoscopic resection for GEDs at Pusan National University Hospital between January 2008 and December 2009 were included in the study. GEDs were morphologically categorized into adenomatous, foveolar, and hybrid types on histologic examination. The clinicopathologic characteristics of patients with GEDs and outcomes of endoscopic resection were analyzed.

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Gastric Mucosal Dysplasia: What is its Clinical Significance?

Cited by 58 publications

References 0 publications

Evaluation of gastric polyps detected by endoscopy: A single-center study of a four-year experience in Turkey

Evaluation of gastric polyps detected by endoscopy: A single-center study of a four-year experience in Turkey

Chronic (Nonerosive) Gastritis: Pathogenesis and Management

Gastric epithelial dysplasia: Characteristics and long-term follow-up results after endoscopic resection according to morphological categorization.

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