Gastric Mucosal Energy Metabolism in Stress Ulcer

Balibrea, J.L.; Canela, M; Salvá, J A; Puig, Manuel Licea; Schwartz, S.; Rull, M

doi:10.1159/000128310

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…Despite some studies that indicate the contrary (12,137), most authors agree that histamine is increased in the gastric mucosa during stress (10,15,33,127,158). Stress also increases histamine levels in the colon and liver (60,127).…”

Section: Trh Among the Effects Of Crh Onmentioning

confidence: 98%

Effect of psychogenic stress on gastrointestinal function

Medina

2000

J Physiol Biochem

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This review summarizes the studies published over the last twenty years on the effects of psychogenic stress on gastrointestinal function, using animal models. The effects of stress on gastric ulceration have received wide attention and the central and local mechanisms of mucosal damage have been, for the most part, clearly delineated. In comparison, relatively few studies have focused on the impact of stress on intestinal and colonic physiology, even though its influence on intestinal motility, mucosal permeability and inflammation has been established. More work is necessary in this field, especially considering the importance of irritable bowel syndrome in modern society.

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Section: Trh Among the Effects Of Crh Onmentioning

confidence: 98%

Effect of psychogenic stress on gastrointestinal function

Medina

2000

J Physiol Biochem

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“…The role of cellular energy deprivation in experimen tal stress ulcer was studied by us [6]: a progressive decrease of glucose levels in gastric mucosa was found; in addition a marked increase in the concentration of free fatty acids was observed, suggesting an alteration in the phospholipid composition of the cell membrane, due to the activating action of histamine on local phospholi pases. This degradation should be taken into account to explain the decrease in mucosal cholesterol concentra tion.…”

Section: Experimental Models For Stress Ulcermentioning

confidence: 99%

Somatostatin in the Management of Gastrointestinal Hemorrhage: Bleeding Ulcers

Balibrea

Torres²,

Merlo³

et al. 1988

Horm Res

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Stress ulcers are characterized by difficult management and poor prognosis. They currently represent a complication in the clinical course of other conditions, mainly shock states. The pathogenesis of stress ulcers is not well understood although the role of hypovolemia leading to energetic deprivation and instauration of anaerobic cellular metabolism have been carefully studied. Somatostatin has been found to reduce the incidence of experimental stress ulcers. In the clinic, patients with duodenal ulcers were found to exhibit a low number of antral D cells and a significant decrease in tissue somatostatin. In a multicenter trial, patients with bleeding peptic or stress ulcers were treated with somatostatin or cimetidine plus pirenzepine. Results were favorable to the former substance on account of the time required to stop the hemorrhage and the demands for blood replacement. Thus, medical management of bleeding ulcers with somatostatin may represent an alternative to more radical surgical intervention.

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Gastric Mucosal Energy Metabolism in Stress Ulcer

Cited by 2 publications

References 13 publications

Effect of psychogenic stress on gastrointestinal function

Effect of psychogenic stress on gastrointestinal function

Somatostatin in the Management of Gastrointestinal Hemorrhage: Bleeding Ulcers

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