Gastric per-oral endoscopic myotomy for refractory gastroparesis: results from the first multicenter study on endoscopic pyloromyotomy (with video)

Khashab, Mouen A.; Ngamruengphong, Saowanee; Carr‐Locke, David L.; Bapaye, Amol; Benias, Petros C.; Serouya, Sam; Dorwat, Shivangi; Chaves, Dalton Marques; Artifon, Everson L.; Moura, Eduardo Guimarães Hourneaux de; Kumbhari, Vivek; Chavez, Yamile Haito; Bukhari, Majidah; Hajiyeva, Gulara; Ismail, Amr; Chen, Yen I.; Lee, Hyuk-Joon

doi:10.1016/j.gie.2016.06.048

Cited by 195 publications

(145 citation statements)

References 16 publications

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“…G‐POEM has been performed for the first time in the United States, and subsequently in Europe by our team with promising results. Since then, three series have been published including seven, 23 and 30 patients respectively . Those reports showed an initial efficacy rate around 80%, representing the most promising and highest rate achieved in this disease to date.…”

Section: Introductionmentioning

confidence: 99%

G‐POEM with antro‐pyloromyotomy for the treatment of refractory gastroparesis: mid‐term follow‐up and factors predicting outcome

Gonzalez

Benezech

Vitton

et al. 2017

Aliment Pharmacol Ther

138

117

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Section: Introductionmentioning

confidence: 99%

G‐POEM with antro‐pyloromyotomy for the treatment of refractory gastroparesis: mid‐term follow‐up and factors predicting outcome

Gonzalez

Benezech

Vitton

et al. 2017

Aliment Pharmacol Ther

138

117

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show abstract

“…The result after a 3-month follow-up also suggested that G-POEM achieved symptomatic relief and objective improvement in gastric emptying. A multicenter study also supported this result, 43 in which 30 patients underwent G-POEM successfully with a clinical response rate of up to 86% during a short follow-up. All these studies suggest that POEM has excellent safety and efficacy.…”

Section: Gastroparesismentioning

confidence: 54%

POEM for special patient cohorts: A review

Zhang

et al. 2017

J of Digest Diseases

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Peroral endoscopic myotomy (POEM) is a natural orifice, translumenal endoscopic surgical procedure that achieves endoscopic myotomy by conducting a submucosal tunnel as an operating space. It is conventionally performed in achalasia. Recently, several centers worldwide have reported the feasibility of this procedure not only in early achalasia but also in other particular patient cohorts. Possible indications for POEM include previously failed Heller myotomy, pneumatic balloon dilatation or POEM, sigmoid achalasia, pediatric patients, spastic esophagus disorders, Zenker's diverticulum and gastroparesis. However, its application in large numbers of special patient groups awaits knowledge of the long-term outcome and greater experience with POEM.

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“…We have previously reported per-rectal endoscopic myotomy (PREM) for adult Hirschsprung's disease [3]. The rationale of this is to disrupt the spastic bowel segments, like those in achalasia or pylorospasm are disrupted by peroral endoscopic myotomy (POEM) or pyloromyotomy (G-POEM) [4,5]. This report describes the technique and outcome of PREM in a pediatric patient with Hirschsprung's disease.…”

mentioning

confidence: 99%

Per-rectal endoscopic myotomy (PREM) for pediatric Hirschsprung’s disease

et al. 2018

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's disease is a congenital disorder characterized by the absence of intrinsic ganglion cells in the myenteric plexuses of the hindgut. The majority of patients present during infancy or childhood with constipation, intestinal obstruction, or megacolon [1]. Standard treatment includes single-or multi-stage pull-through surgery [2]. We have previously reported per-rectal endoscopic myotomy (PREM) for adult Hirschsprung's disease [3]. The rationale of this is to disrupt the spastic bowel segments, like those in achalasia or pylorospasm are disrupted by peroral endoscopic myotomy (POEM) or pyloromyotomy (G-POEM) [4, 5]. This report describes the technique and outcome of PREM in a pediatric patient with Hirschsprung's disease. An 8-year-old boy had had refractory constipation since the neonatal period that was partially relieved by high-dose laxatives. Barium enema demonstrated a spastic rectum and dilated sigmoid colon, which were classical of Hirschsprung's disease (▶ Fig. 1). Colonoscopy showed a spastic non-distensible empty rectum and dilated sigmoid colon with stool residue. Deep mucosal biopsies demonstrated ganglion cells at 8 cm but these were absent distally (▶ Fig. 2). Manometry demonstrated absent rectoanal inhibitory reflex (RAIR). Given our previous experience, we obtained consent for PREM from the patient's parents. PREM was performed ▶ Fig. 1 Barium enema in an 8-year-old boy showing the characteristic signs of Hirschsprung's disease.

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Gastric per-oral endoscopic myotomy for refractory gastroparesis: results from the first multicenter study on endoscopic pyloromyotomy (with video)

Cited by 195 publications

References 16 publications

G‐POEM with antro‐pyloromyotomy for the treatment of refractory gastroparesis: mid‐term follow‐up and factors predicting outcome

G‐POEM with antro‐pyloromyotomy for the treatment of refractory gastroparesis: mid‐term follow‐up and factors predicting outcome

POEM for special patient cohorts: A review

Per-rectal endoscopic myotomy (PREM) for pediatric Hirschsprung’s disease

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