Gastric Pit Density and Depth of Foveolae of the Gastric Body Mucosa Assessed by Dye Endoscopy

Abstract

We examined the histological characteristics of the foveolur zone of the gastric body mucosa, using dye endoscopy and endoscopic biopsy. In 63 patients, the gastric area type of the gastric body was placed in one of the following categories ; fundic gland type 0 (Fo), where small and fine areas are arranged closely to one another ; F I , where the areas are largest in size, round and high ; F z , where the areas are intemediate in size but not so high ; F3, where small and flat areas are loosely arranged ; pseudo-pyloric gland ty$e 1 (Pbr), where the areas are regular in size and arrangement; and the completely atrophic gland type (Pbz) with areas irregular in size and arrangement. The histological characteristics of the foveolar zone were emmined o n printed microphotographs of the biopsy specimens of the gastric body. The density of the gastric pit was defined as the number of pits in a 1 mm width of the mucosal surface and depth of the foveolue was measured as the distance between the top and bottom (or the isthmus) of the foveolue as seen on vertical sections. The gastric pit density and depth of the foveolue were dense and shallow, respectively, in FO and sparse and deep, in Pbl and Pbz respectively. The degree of these factors showed independency in area types Fo, F I and Pbz and there were correlations of P<O.O33 and P<O.OOl between F Z and Pbr, F3 and Pbr, respectively. Our observations may be useful to define atrophic gastritis in the gastric body mucosa, in terms of the gastric area types.

Newly proposed quantitative criteria can assess chronic atrophic gastritis via probe-based confocal laser endomicroscopy (pCLE): a pilot study

“…First, we confirmed that gastric gland density is directly correlated with CAG severity in both pCLE and histological evaluations. This finding agrees with previous histological morphometric studies 8 13 14 . Second, we found that compared to NAG, CAG patients had larger and smaller gland areas measured on pCLE; this variation correlated with CAG grade.…”

“…First, although we found that the median number of glands per patient decreased as CAG severity increased, as reported in previous studies 24 26 , a standardized pCLE AOI for gland counting remains undefined. The use of standardized histological analysis parameters, such as glands/mL 8 or glands/40X microscope field, would make defining an AOI possible 14 . Indeed, our studyʼs pCLE images were obtained from the gastric body mucosa, limiting its applicability in those patients with atrophic gastric in the gastric antrum and pyloric gland region.…”

“…To reduce the histological misclassification, the updated Sydney system, established in Houston in 1994, proposed that CAG be graded as mild, moderate, or severe, using a visual analog scale 7 . The severity of atrophic gastritis is based on the gradual loss and subsequently decreased density of gastric glands 8 , which are associated with chronicity features such as an increased inter-glandular distance, foveolar hyperplasia 9 , and intestinal metaplasia 10 . However, this system produces only a moderate interobserver agreement, mainly due to the visual analog scale limitations 11 12 .…”

Gastric foveolar elongation causes invisibility of regular arrangement of collecting venules in chronic active and inactive gastritis

“…All the assessment of gastric specimens was standard scored by two pathologists and the foveolar length measured by two pathologists on sections vertical to the mucosal surface using an image analysis system (ToupView, Hangzhou Touptek Photonics Co. Ltd,), as described previously 10 . Values were expressed as the mean of measurements along three or more different foveolae described previously 13,14 . Total 322 upper gastrointestinal tract endoscopic biopsies were screened to identify 274 sections technically suitable for the study.…”

“…10 Values were expressed as the mean of measurements along three or more different foveolae described previously. 13,14 Total 322 upper gastrointestinal tract endoscopic biopsies were screened to identify 274 sections technically suitable for the study.…”