Gastric Plexiform Fibromyxoma, an Uncommon Mesenchymal Tumor

Álvarez, Cristina Magadán; Olmos-Martínez, Jose M.; Carrera, M S Trugeda; Díaz, María José Fernández; Martínez, Enrique Toledo; Horts, Remigio Mazorra; Fernández, María Concepción López; Pacheco, Rubén Darío Arias; Rivas, Berta Martín

doi:10.17235/reed.2020.7048/2020

Cited by 8 publications

(6 citation statements)

References 14 publications

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“…Our case mirrors other PF cases histopathologically in presenting with a multinodular proliferation of bland spindle cells and arborizing capillaries in a myxoid stroma. Similarly, minimal cytologic atypia and low mitotic count have consistently reported in previous cases [ [7] , [8] , [9] ]. PF may easily be under recognized or misinterpreted without the pathologists' awareness of this entity and performing unnecessarily many immunostains.…”

Section: Discussionsupporting

confidence: 75%

Viscus perforation as an initial presentation of plexiform fibromyxoma: A case report and review of the literature

Mremi

Nyoni

Elisante

et al. 2023

International Journal of Surgery Case Reports

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Section: Discussionsupporting

confidence: 75%

Viscus perforation as an initial presentation of plexiform fibromyxoma: A case report and review of the literature

Mremi

Nyoni

Elisante

et al. 2023

International Journal of Surgery Case Reports

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“…Three months later, he experienced a second episode of intestinal obstruction that required resection and a new intestinal anastomosis, with no macroscopic or microscopic tumor evidence. During follow-up, there were no clinical or radiological recurrences in our patient, consistent with the benign behavior of the tumor described in most previously published works 17 …”

Section: Discussionsupporting

confidence: 91%

“…During follow-up, there were no clinical or radiological recurrences in our patient, consistent with the benign behavior of the tumor described in most previously published works. 17 Nevertheless, in a recently published study, Ayyanar et al 18 presented the case of a patient with gastric plexiform fibromyxoma who, 4 months after distal gastrectomy, developed recurrence and bilateral ovarian and hepatic metastases. The patient passed away 4 months after the surgery.…”

Section: Discussionmentioning

confidence: 99%

Pediatric Plexiform Fibromyxoma: A Case Report

Bugeda Gómez,

Costa-Roig,

Montecino Romanini

et al. 2024

Journal of Pediatric Hematology/Oncology

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The plexiform fibromyxoma is a rare mesenchymal tumor in adults that generally originates in the antrum of stomach, being its occurrence in pediatric patients exceptional. It was classified as a distinct entity by World Health Organization in 2010. No recurrences and metastases have been documented in many of the reported patients to date, being the surgical treatment curative. We report the case of a 3-month-old infant who presented to the emergency department with an episode of intestinal subocclusion requiring an emergent surgery. During the surgical intervention, a mass was identified in the jejunum, causing partial occlusion of its lumen. The surgical pathology report revealed an infiltrative tumor composed of spindle-shaped cells disposed in a stroma with a plexiform pattern alternating myxoid areas. These findings and the immunohistochemical characteristics of the neoplastic cells led to classify the tumor as a plexiform fibromyxoma. A description of the immunophenotype of this tumor is made and differential diagnosis with other gastrointestinal tumors is also discussed.

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“…To better understand the clinicopathologic features of PF, we performed a brief review of the literature (Table 1). 1–51 Taking the present study into account, the tumor is located mainly in the gastric antrum and pylorus (76%), but other rare locations, such as the gastric fundus, gastric body, duodenum, jejunum, cecum, gallbladder, posterior mediastinum, and esophagus, have also been reported. 2 , 17 , 29 , 47 The overall median and average ages of patients with PF at diagnosis were 46 years and 43.3 years, respectively (range, 5 to 81 years).…”

Section: Discussionmentioning

confidence: 71%

Plexiform fibromyxoma: a clinicopathological and immunohistochemical analysis of two cases with a literature review

Wang

et al. 2021

J Int Med Res

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Objective This article aimed to study the clinicopathological features, immunophenotypes, and differential diagnoses of plexiform fibromyxoma (PF). Methods We searched clinical and pathology databases of our hospital for patients with histologically confirmed PF from 2007 to 2020 and reviewed the relevant English and Chinese language literature. Results Two cases of PF were identified, a 67-year-old woman and a 23-year-old man. Both patients presented with melena and anemia and underwent partial gastrectomy. Histologically, the tumors exhibited a plexiform growth pattern in the gastric submucosa and the presence of bland-looking spindle cells in the fibromyxoid stroma with the formation of small blood vessels. Immunohistochemically, the two cases were strongly positive for vimentin, smooth muscle actin, and muscle-specific actin and negative for CD117, discovered on gastrointestinal stromal tumors protein 1, CD34, CD10, S100, desmin, H-caldesmon, estrogen receptor, progesterone receptor, β-catenin, and cytokeratin. Conclusions PF is a rare mesenchymal tumor of the stomach that can be distinguished from other gastrointestinal mesenchymal tumors based on its distinctive morphology and immunophenotype.

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Gastric Plexiform Fibromyxoma, an Uncommon Mesenchymal Tumor

Cited by 8 publications

References 14 publications

Viscus perforation as an initial presentation of plexiform fibromyxoma: A case report and review of the literature

Viscus perforation as an initial presentation of plexiform fibromyxoma: A case report and review of the literature

Pediatric Plexiform Fibromyxoma: A Case Report

Plexiform fibromyxoma: a clinicopathological and immunohistochemical analysis of two cases with a literature review

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