Gastric polyps: Association with Helicobacter pylori status and the pathology of the surrounding mucosa, a cross sectional study

Elhanafi, Sherif; Saadi, Mohammed; Lou, Wynee; Mallawaarachchi, Indika; Dwivedi, Alok; Zuckerman, Marc J.; Othman, Mohamed O.

doi:10.4253/wjge.v7.i10.995

Cited by 46 publications

(39 citation statements)

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“…The greatest frequency of small polyps is also reported in the litera- Indeed, it is admitted that hyperplastic polyps develop most commonly within an inflammatory gastric mucosa infected with Hp [18] [19] [20].…”

Section: Discussionmentioning

confidence: 99%

Gastric Polyps in a Digestive Endoscopy Center in Dakar

Bassène¹,

Diallo²,

Thioubou³

et al. 2017

OJGas

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Introduction: The gastric polyp is a tumor protruding into the gastric lumen. It is asymptomatic most often with a risk of malignant degeneration closely related to its histological nature. These data are very rare in Africa. Objectives: Reporting the frequency and endoscopic and histological characteristics of gastric polyps in the digestive endoscopy center of Aristide Le Dantec hospital in Dakar. Patients and methods: This was a retrospective study carried out in the digestive endoscopy center of Aristide Le Dantec Hospital in Dakar from January 2012 to December 2016. We have included all patients with one or more gastric polyps coupled with histological findings available. Results: There were 60 patients with gastric polyps, hence a prevalence of 0.8%. We included 37 patients. Their mean age was 46 years [21 years -75 years]. The sex-ratio was 0.48. Epigastralgia was the most frequent endoscopic indication (51.3%). The polyp was unique in 26 patients (70.3%) with an average size of 6.87 mm [2 -15 mm]. Polyps were sessile in 31 cases (83.8%) and pediculate in 6 cases (16.2%). They were most often in the antrum (51.4%). Antral erosions (13.5%) and fundic atrophy (13.5%) were the main associated endoscopic lesions. These were hyperplastic polyps in 27% of cases and adenoma in 16.2% of cases. Chronic atrophic gastritis (10.8%) and intestinal metaplasia (10.8%) were the main histological lesions associated with polyps. Helicobacter pylori (Hp) were present in 17 patients (45.9%). Conclusion: The prevalence of gastric polyps is 0.8% in the endoscopy center of Aristide Le Dantec hospital. They are usually hyperplastic or adenomatous.

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Section: Discussionmentioning

confidence: 99%

Gastric Polyps in a Digestive Endoscopy Center in Dakar

Bassène¹,

Diallo²,

Thioubou³

et al. 2017

OJGas

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“…H. pylori is a spiral-shaped bacterium that grows in the mucus layer which coats the inside of the human stomach, ultimately causing inflammation in the stomach called gastritis [62]. Further, it turns to ulcers [63, 64], long-lasting anaemia [65–67], and growths in the stomach [68, 69], which are more likely to get cancer. H. pylori is mainly spread through contaminated water, food, saliva, or mouth to mouth contacts and possibly transmitted sexually via oral-genital contact [70, 71].…”

Section: Clinical Associationmentioning

confidence: 99%

Status of Epstein-Barr Virus Coinfection withHelicobacter pyloriin Gastric Cancer

Singh

Jha

2017

Journal of Oncology

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Epstein-Barr virus is a ubiquitous human herpesvirus whose primary infection causes mononucleosis, Burkett's lymphoma, nasopharyngeal carcinoma, autoimmune diseases, and gastric cancer (GC). The persistent infection causes malignancies in lymph and epithelial cells. Helicobacter pylori causes gastritis in human with chronic inflammation. This chronic inflammation is thought to be the cause of genomic instability. About 45%-word population have a probability of having both pathogens, namely, H. pylori and EBV. Approximately 180 per hundred thousand population is developing GC along with many gastric abnormalities. This makes GC the third leading cause of cancer-related death worldwide. Although lots of research are carried out individually for EBV and H. pylori, still there are very few reports available on coinfection of both pathogens. Recent studies suggested that EBV and H. pylori coinfection increases the occurrence of GC as well as the early age of GC detection comparing to individual infection. The aim of this review is to present status on coinfection of both pathogens and their association with GC.

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“…In this work all detected polyps are fundic gland and in all cases Hp was negative (n = 14; 11.86%), but this association wasnot confirmed by analyzing the confidence interval obtained. No hyperplastic polyp (associated with the presence of HP and with congestive gastropathy) was found and also no adenomatous polyp (associated with intestinal metaplasia) [22,23]. 'Polyps fundic gland, red streaks and normal mucosal appearance correlate with the negativity of Hp infection as other studies [19,22,23].…”

Section: Discussionmentioning

confidence: 70%

Endoscopic Findings Related To Helicobacter Pylori

2018

MCR

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Background: Studies with the latest technologies such as endoscopy with magnification and chromoendoscopy showed that various endoscopic aspects are clearly related to infection by Helicobacter pylori (Hp). The description of different patterns of erythema in gastric body under magnification of images revived interest in identifying these patterns by standard endoscopy. Aim: To validate the morphologic features of gastric mucosa to conventional gastroscopy Hprelated gastritis allowing predictability of their diagnosis as well as proper targeting biopsies. Methods: Prospective study of 339 consecutive patients with the standard videoendoscope image analysis were obtained, recorded and stored in a program database. These images were studied with respect to the presence or absence of HP, diagnosed by rapid urease test and/or by histological analysis. Were studied: a) normal mucosa appearance; b) mucosal nodularity; c) diffuse nonspecific erythemaor redness of antrum and body; d) mosaic pattern with focal area of hyperemia; e) erythema in streaks or bands (red streaks); f) raised erosions; g) flat erosions; h) fundic gland polyps. The main exclusion criteria were the use of drugs, Hp pre-treatment and other entities that could affect results. Results: Applying the exclusion criteria, were included 170 of the 339 patients, of which 52 (30.58%) were positive for Hp and 118 negative. On the positive findings, the most associated with infection were: antralnodularity (26.92%); raised erosion (15.38%) and mosaic pattern in the body (21,15%). On the negative group the normal appearance of the mucosa was 66.94%; red streaks in 9.32%; flat erosions 11.86%; and fundic gland polyps 11.86%. Conclusion: Endoscopic findings are useful in predicting the outcome, localization and targeting of biopsies in gastritis related to Helicobacter pylori infection.The most representative form of Hp related gastritis was the nodularity of the antralmucosa. Diffuse redness and mosaic pattern in the bodyare closely related to Hp infection.Raised erosions are suggestive but not specific to the infection. Normal-appearing forms, red streaks and fundic gland polyposis are related to the negativity of Helicobacter pylori infection. Flat erosions were not conclusive of the presence or absence of Hp.

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Gastric polyps: Association with Helicobacter pylori status and the pathology of the surrounding mucosa, a cross sectional study

Abstract: Gastric hyperplastic polyps were significantly associated with positive H. pylori status and portal hypertensive gastropathy as compared with fundic gland polyps.

Cited by 46 publications

References 44 publications

Gastric Polyps in a Digestive Endoscopy Center in Dakar

Gastric Polyps in a Digestive Endoscopy Center in Dakar

Status of Epstein-Barr Virus Coinfection withHelicobacter pyloriin Gastric Cancer

Endoscopic Findings Related To Helicobacter Pylori

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