Gastric Precancerous Lesions in First Degree Relatives of Patients with Known Gastric Cancer: a Cross-Sectional Prospective Study in Guilan Province, North of Iran

Ghanaei, F Mansour; Joukar, Farahnaz; Baghaei, Seyed Mohammad; Yousefi-Mashhoor, Mahmood; Naghipour, Mohammadreza; Sanaei, Omid; Naghdipour, M.; Shafighnia, Shora; Atrkarroushan, Zahra

doi:10.7314/apjcp.2012.13.5.1779

Cited by 23 publications

(21 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this respect, Ganaei, in a case-control group study, reported 21.6, 1.7, and 0.4% prevalences of IM, atrophy, and dysplasia in northern Iran on the basis of pathological findings (Mansour-Ghanaei et al, 2012a, 2012b. In reference to other countries worldwide, our values are also lower than those in reports from high-risk countries such as Japan, South Korea, Columbia, and China (Correa et al, 1990;You et al, 1999;Kim et al, 2008;Jemal et al, 2011;Asaka, 2012;Joo et al, 2013), but slightly higher than those in intermediate-risk countries (Muller et al, 2007;Eriksson et al, 2008;Yako-Suketomo and Katanoda, 2009).…”

Section: Discussionmentioning

confidence: 94%

“…In Iran, this is a very important fact as this country is categorized as an intermediate-risk area, where the seroprevalance of H. pylori infection reaches 62-90% (Malekzadeh et al, 2004;Islami and Kamangar, 2008;Mansour-Ghanaei et al, 2012a, 2012b. Some parts of Iran are also considered high-prevalence areas (Hossein Somi et al, 2006;Malekzadeh et al, 2009;Mansour-Ghanaei et al, 2012a, 2012b. In the present study, the prevalence of precancerous lesions including atrophy, IM, and dysplasia and their relation with some common risk factors were evaluated in a population of chronic dyspeptic patients.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence of gastric precancerous lesions among chronic dyspeptic patients and related common risk factors

Ajdarkosh

Sohrabi

Moradniani

et al. 2015

European Journal of Cancer Prevention

View full text Add to dashboard Cite

Gastric cancer is one of the leading causes of cancer-related deaths worldwide. Progression of gastric cancer follows several steps from gastritis to atrophy, intestinal metaplasia, dysplasia, and finally cancer. The aim of this study was to determine the prevalence of gastric precancerous lesions and related common risk factors in a group of chronic dyspeptic patients. A total of 688 chronic dyspeptic patients older than 40 years of age were consecutively enrolled. The exclusion criteria were pregnancy, and a history of gastric cancer and gastric surgery. A questionnaire including demographic and clinical data, smoking habits, alcohol use, NSAIDs, and regular aspirin use was completed for all patients. Upper endoscopy and gastric biopsy were performed for all of the participants according to the standard protocols. Upper endoscopy was performed for all of the participants and biopsies were taken according to the biopsy protocol. The specimens were examined in a blinded manner by two expert gastrointestinal pathologists. The mean age of the participants was 57.87±9.10 years; there were 361 (52.5%) women. The prevalence of intestinal metaplasia, gastric atrophy, dysplasia, and positive Helicobacter pylori infection was 19.8, 12.8, 3.2%, and 64.5%, respectively. Age and H. pylori infection showed a significant association with pathological findings (odds ratio=3.10, 95% confidence interval: 1.91-4.72 and odds ratio=3.56, 95% confidence interval: 2.30-5.53, respectively). According to the high prevalence of precancerous lesions in patients with chronic dyspepsia who were older than 40 years of age, upper endoscopy and gastric mapping sampling for the detection of these lesions is recommended in intermediate-risk to high-risk areas.

show abstract

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Prevalence of gastric precancerous lesions among chronic dyspeptic patients and related common risk factors

Ajdarkosh

Sohrabi

Moradniani

et al. 2015

European Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…According to a meta-analysis of six studies, the rates of AG and IM among subjects with family history of gastric cancer were 2.2- and 1.98-fold higher, respectively, than in subjects without a family history [15]. However, a study from Iran in 2012 reported that a family history of gastric cancer was associated with an increased incidence of IM, but not AG [70]. In addition, Oh et al [71] reported that first-degree relatives had an adjusted OR of 2.69 (95% CI, 1.1 to 6.8; p = 0.037) for antral IM in males in a multivariable regression analysis, but there was no such effect on AG.…”

Section: Effect Of Family History On the Outcome Of Gastric Cancermentioning

confidence: 99%

Gastric cancer and family history

Choi

Kim

2016

Korean J Intern Med

136

View full text Add to dashboard Cite

Gastric cancer is associated with high morbidity and mortality rates worldwide. Identifying individuals at high risk is important for surveillance and prevention of gastric cancer. Having first-degree relatives diagnosed with gastric cancer is a strong and consistent risk factor for gastric cancer, but the pathogenic mechanisms behind this familial aggregation are unclear. Against this background, we reviewed the risk factors for gastric cancer in those with a first-degree relative with gastric cancer, and the possible causes for familial clustering of gastric cancer including bacterial factors, inherited genetic susceptibility, environmental factors or a combination thereof. Among individuals with a family history, current or past Helicobacter pylori infection, having two or more first-degree affected relatives or female gender was associated with an increased risk of developing gastric cancer. To date, no specific single nucleotide polymorphism has been shown to be associated with familial clustering of gastric cancer. H. pylori eradication is the most important strategy for preventing gastric cancer in first-degree relatives of gastric cancer patients, particularly those in their 20s and 30s. Early H. pylori eradication could prevent the progression to intestinal metaplasia and reduce the synergistic effect on gastric carcinogenesis in individuals with both H. pylori infection and a family history. Endoscopic surveillance is also expected to benefit individuals with a family history. Further large-scale, prospective studies are warranted to evaluate the cost-effectiveness and optimal time point for endoscopy in this population. Moreover, genome-wide association studies that incorporate environmental and dietary factors on a ‘big data’ basis will increase our understanding of the pathogenesis of gastric cancer.

show abstract

“…From another study exists evidence that key factor in development of gastric cancer p53 gene intron alterations may contribute gastritis development and early detection of these alterations in precancerous lesions such as gastritis may be useful for prediction of risk developing of gastric cancer (Najjar Sadeghi et al, 2013). Gastric cancer is partly a hereditary disease and according recently study the infection Helicobacter pylori and the stomach lesions such as dysplasia, atrophy and chronic gastritis have been met more frequently in individuals with a family history of gastric cancer (Mansour-Ghanaei et al, 2012). In most cases the infection Helicobacter pylori is asymptomatic.…”

Section: Introductionmentioning

confidence: 99%

Association of Cytokine Gene Polymorphisms with Gastritis in a Kazakh Population

Kulmambetova¹,

Imanbekova²,

Logvinenko³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Gastric Precancerous Lesions in First Degree Relatives of Patients with Known Gastric Cancer: a Cross-Sectional Prospective Study in Guilan Province, North of Iran

Cited by 23 publications

References 21 publications

Prevalence of gastric precancerous lesions among chronic dyspeptic patients and related common risk factors

Prevalence of gastric precancerous lesions among chronic dyspeptic patients and related common risk factors

Gastric cancer and family history

Association of Cytokine Gene Polymorphisms with Gastritis in a Kazakh Population

Contact Info

Product

Resources

About