Gastric secretion during pregnancy and lactation in the rat

Lilja, B.; Svensson, Sören

doi:10.1113/jphysiol.1967.sp008206

Cited by 25 publications

(8 citation statements)

References 22 publications

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“…During the last trimester of pregnancy, as well as post partum and during lactation, gastric acidity has generally been found to increase. 49 increased ulceration index in late pregnancy seem to parallel these clinical findings, in contrast to both Kahlson's 41 and Robert's 67 experimental results.…”

Section: Vol XXXI No I 1969contrasting

confidence: 82%

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Influence of Pregnancy Upon Gastric Ulcers Induced by Restraint

Luther

Heistad

Sparber

1969

Psychosomatic Medicine

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Gastric ulcers were induced in pregnant rats using a modification of Senay and Levhe's74 technique of restraint in a cold environment. Under these experimental conditions, pregnancy did not generate ulcer protection and, in fact, increased ulcer incidence was found at the end (twentieth day) of pregnancy. These results are at variance with other reports that pregnancy offered protection against chemically induced gastric ulceration, but seem to confirm clinical observations that an exacerbation of ulcer symptomatology occurs toward the end of pregnancy.

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Section: Vol XXXI No I 1969contrasting

confidence: 82%

“…49 ' 90 The homeostatic mechanism preventing endogenous histamine from producing ulceration can in all probability take care of the exogenous, injected histamine also. The increased levels of histaminase during pregnancy 8 generally have been thought to be related to the improvement of ulcer symptoms 8 by decreasing acidity.…”

Section: Resultsmentioning

confidence: 99%

Influence of Pregnancy Upon Gastric Ulcers Induced by Restraint

Luther

Heistad

Sparber

1969

Psychosomatic Medicine

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“…Lilija and Svensson (22) and Takeuchi and Okabe (4) reported significant increases in gastric acid secretion during pregnancy and lactation in rats. The acid hypersecretion during pregnancy was associated with increased vagal stimulation and histamine levels.…”

Section: Materials and Methods Animals Femalementioning

confidence: 98%

The Role of Food Intake on Gastric Mucosal Growth and Gastrin Receptors during Pregnancy and Lactation

Takeuchi¹,

Johnson²

1987

Experimental Biology and Medicine

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We examined the effects of pregnancy and lactation on mucosal growth and the numbers and affinity of gastrin receptors in the oxyntic gland mucosa in rats and compared these with changes in serum gastrin levels and food consumption. Gastric mucosal DNA, RNA, and protein contents were significantly increased during lactation. These changes were not observed in either pregnant or nonlactating rats which had given birth at the same time as the lactating animals. The gastrin-binding capacity of a membrane fraction of the oxyntic mucosa was also increased at the corresponding periods in lactating rats (Days 7,15,20). Scatchard plot analysis revealed that the number of gastrin receptors was significantly increased without any change in affinity. Food consumption and levels of serum gastrin remained unaltered in pregnant and nonlactating rats compared to virgin controls, but were significantly increased in lactating rats. Increased serum gastrin levels and gastrin binding capacities in lactating rats (Day 15) were abolished by preventing increased food consumption by means of pair feeding. The results demonstrate that the number of gastrin receptors in the oxyntic mucosa increases during lactation in rats. This increase is probably due to hypergastrinemia caused by increased food intake. The increased number of gastrin receptors may be involved in the mechanism of hypertrophic responses of the gastric mUCOSa in lactating rats. 0

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“…It has already been shown by Kameswaran and West (1962), Lilja and Svensson (1967), and Kahlson and Rosengren (1968) that there is an increase in urinary excretion of histamine in the rat during the last third of pregnancy, and that this increase in maintained until the 20th day when there is a sharp drop at the time of birth of the young. As well as this increase in urinary excretion in the rat Kahlson and Rosengren and co-workers (1958, 1960, 1968) also reported similar increases for the mouse and the hamster during pregnancy.…”

Section: Discussionmentioning

confidence: 96%

“…Grahn et al 1969). Kameswaran and West (1962), Rosengren (1963Rosengren ( , 1965, Maudsley (1964), Lilja and Svensson (1967), and Kahlson and Rosengren (1968) all suggest that the increased histamine production is mainly of foetal origin. However, the main site of production varies and, depending upon the species, may be the foetal liver, the foetal skin, the placenta, or even the kidneys and stomach of the mother.…”

Section: ------~mentioning

confidence: 99%

Histamine Levels in the Blood of Pregnant Mares

Fernandes¹,

Ck²

1972

Aust. Jnl. Of Bio. Sci.

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The problem of histamine metabolism has long been the subject of research. The excretion of histamine during pregnancy has been studied in cats, mice, hamsters, and many other animals, and also in human beings. However, few papers have been published on the levels of histamine in the blood of pregnant animals. In this paper the variation in blood histamine levels in pregnant mares from the first month of pregnancy until term is reported. Materials and MethodsSix pregnant mares of the PSI strain plus two controls were studied. The method followed was that of G-addum modified by Code (1937). Blood was collected in syringes containing heparin and put into· flasks also containing heparin. Proteins· were precipitated with 10% (w/v) trichloroacetic acid and, after standing for 1-1 hr, filtered by suction. This was repeated three times. To the filtrate was added concentrated HOI and this solution was boiled for 90 min in a reflux air condenser, water being added to prevent dessication. Then twice-distilled ethanol was added and the residue dried in vaouo on a hot water-bath. This dried residue was suspended in distilled water and filtered. This was repeated twice. The filtrate was neutralized with 0·2N NaOH and tested on a guinea-pig intestine against a standard histamine solution (1 mgtl ml Tyrode's solution). ResultsFigure 1 shows a typical assay of an extract of pregnant mare's blood. Further details of the assay are given in the legend to the figure. Figure 2 shows the variations in blood histamine levels during pregnancy. It is seen that there is already an increase in histamine concentration in the first two months of pregnancy which is significantly different from control values at P = 0·02. There is a sharp decrease (to control levels) in the third and fourth months, and a slight (not significant) rise in the fifth and sixth months. However, there is a significant increase in blood histamine level In the seventh and eighth months (P < 0·01) and also in the ninth and tenth months of pregnancy (P = 0·05). DiscussionThese results agree with those reported by Kahlson and Rosengren (1968) for other species, namely that there is an increase in histamine concentration in· the blood in the last third or last quarter of pregnancy. However, as we do not have data on histamine levels in mare's blood immediately after birth, we are unable to compare such levels with those of other species.• Manuscript received 21 January 1972. t SecQ8.0 de DoenQas Carenciais e Metab6licas,

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Gastric secretion during pregnancy and lactation in the rat

Cited by 25 publications

References 22 publications

Influence of Pregnancy Upon Gastric Ulcers Induced by Restraint

Influence of Pregnancy Upon Gastric Ulcers Induced by Restraint

The Role of Food Intake on Gastric Mucosal Growth and Gastrin Receptors during Pregnancy and Lactation

Histamine Levels in the Blood of Pregnant Mares

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