Gastric Secretion in Chronic Pancreatitis

Kravetz, Robert E.

doi:10.7326/0003-4819-63-5-776

Cited by 31 publications

(9 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, the relative hypochlorhydria previously noted in patients with alcoholic chronic pancreatitis in response to histamine stimulation also occurs in the postprandial state (Kravetz and Spiro, 1965;Bank et al, 1966;Chey et al, 1968;Gupta and Rao, 1975).…”

Section: Discussionmentioning

confidence: 75%

“…Basal and histamine-stimulated acid outputs are often decreased in chronic pancreatitis (Bank et al, 1966;Chey et al, 1968;Gupta and Rao, 1975;Kravetz and Spiro, 1965), presumably related to the presence of ethanol-induced gastritis, although some authors have noted normal gastric secretory responses to secretagogues (Saunders et al, 1978). However, gastric acid secretion after meals has not been adequately studied.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Postprandial gastric function in pancreatic insufficiency.

Regan¹,

Malagelada²,

DiMagno³

et al. 1979

Gut

View full text Add to dashboard Cite

SUMMARY Abnormalities in postprandial gastric function could contribute to the maldigestion of pancreatic insufficiency. To measure simultaneously postprandial gastric secretion and emptying and correlate these measurements with intraluminal duodenal changes, we performed intestinal intubation and duodenal perfusion during feeding of a solid-liquid test meal in 10 healthy controls and 10 patients with documented pancreatic insufficiency before and after replacement therapy. In pancreatic insufficiency, intraduodenal pH was significantly decreased late in the postprandial period while simultaneously measured duodenal acid loads were normal, confirming that reduced bicarbonate output rather than increased acid delivery was responsible for higher duodenal acidity in these patients. Significant (P < 0O05) reductions in postprandial acid, pepsin, and total secretory outputs were noted in untreated patients only during the first postprandial hour. Absolute gastric emptying rates were lower in patients (P < 0.05) than in healthy subjects, but fractional rates of emptying were similar. Fasting and postprandial hypergastrinaemia were consistently observed in the patients with pancreatic disease. There are postprandial disturbances of secretory function but no primary gastric motor defect in patients with exocrine pancreatic insufficiency.

show abstract

Section: Discussionmentioning

confidence: 75%

mentioning

confidence: 99%

Postprandial gastric function in pancreatic insufficiency.

Regan¹,

Malagelada²,

DiMagno³

et al. 1979

Gut

View full text Add to dashboard Cite

show abstract

“…Unfortunately there have been no studies correlating iron absorption with pancreatic and gastric secretory function or duodenal pH in animals. Furthermore, there is no evidence for gastric hypersecretion in patients with chronic pancreatic disease (Kravetz and Spiro, 1965;Bank, Marks, and Groll, 1966).…”

Section: Discussionmentioning

confidence: 99%

Effect of the exocrine pancreatic secretions on iron absorption.

Kavin¹,

Charlton²,

Jacobs³

et al. 1967

Gut

View full text Add to dashboard Cite

“…without knowledge of the acid output. They were classified as (1) nor¬ mal; (2) superficial gastritis-infiltration of the lamina propia with lymphocytes, plasma cells, and eosinophils with little or Atrophie Gastritis (15) A pancreozymin-secretin test was per¬ formed to measure pancreatic exocrine se¬ cretion according to the method previously reported from our laboratory.12 Liver biopsy was obtained with a Menghini needle through an intercostal approach. Specimens were graded according to the criteria of Rubin and Lieber.13 Forty-three male volunteers, compar¬ able in age to the test group, served as con¬ trols.…”

Section: Methodsmentioning

confidence: 99%

Gastric Secretion and Gastric Mucosal Morphology in Chronic Alcoholics

Dinoso¹

1972

Arch Intern Med

View full text Add to dashboard Cite

Four to eight weeks after the cessation of alcohol intake, 70 alcoholics underwent gastric biopsies, gastric analysis, pancreozyminsecretin test, and liver biopsy. Biopsies revealed gastritis in 50% of body specimens and in 84% from the antrum. Correlation of biopsies with acid secretion revealed that maximal acid output (MAO) was 4.63 mEq/hr in atrophic gastritis, 22.40 mEq/hr in superficial gastritis and 26.97 mEq/hr in those with normal mucosa. There was no correlation between MAO and liver biopsy findings or pancreatic exocrine function. In 12 patients with gastritis studied serially during abstinence up to nine months, four showed increases in MAO which paralleled histological improvement. Our observations indicate that chronic alcohol ingestion is associated with an increased incidence of gastritis. In a significant percentage of these patients, mucosal recovery follows abstinence or adequate nutrition, or both.Pevious studies in chronic al¬ coholics and in patients with dis¬ eases associated with excessive alco¬ hol intake such as cirrhosis or pancreatitis have demonstrated de¬ rangement of gastric secretory func¬ tion or structure of the gastric mu¬ cosa, or both. Several groups of investigators1"1 reported a high inci¬ dence of gastritis in chronic alcoholics and some reported hyposecretion of acid in alcoholic subjects with cir¬ rhosis45 or chronic pancreatitis.6 Normal 31 (50.0%) 24 (85.7%)S uperficial gastritis_16 (25.8%)_3 (10.7%) Atrophie gastritis_15 (24.2%) _1 ( 3.6%)However, correlative studies between mucosal histology and acid secretion were not done in any of these reports.In a recent study7 we demonstrated a decrease in basal and maximal acid output in response to histamine ad¬ ministration and a high incidence of superficial and atrophie gastritis in a group of chronic alcoholics and in pa¬ tients with chronic pancreatitis asso¬ ciated with alcoholism. In the present communication, we extended our ob¬ servations on gastric secretory func¬ tion and gastric mucosal histology in 70 alcoholics and followed changes in these areas serially over a period of up to nine months in a limited num¬ ber of patients after the cessation of alcohol intake. Since the liver8·9 and the exocrine pancreatic function1011 have been shown previously to influ¬ ence gastric secretion of acid in dogs, we evaluated also the histology and function of the liver and pancreatic exocrine secretion. Materials and Methods

show abstract

Gastric Secretion in Chronic Pancreatitis

Cited by 31 publications

References 14 publications

Postprandial gastric function in pancreatic insufficiency.

Postprandial gastric function in pancreatic insufficiency.

Effect of the exocrine pancreatic secretions on iron absorption.

Gastric Secretion and Gastric Mucosal Morphology in Chronic Alcoholics

Contact Info

Product

Resources

About