Gastric Secretion Stimulated by Gastrin-like AOC-tetrapeptide

Yamagata, Shoichi; Masuda, Hisayuki; Ishimori, Akira; Inoue, Sumito; Wada, Takeo; Sato, Katsuaki; Kinoshita, Hiroshi; Nose, Takashi; Masuda, Masasuke; Kawai, Keiichi; Uematsu, Toshiki; Sato, H.; Yunoki, K.; Sasahira, S.

doi:10.1620/tjem.101.103

Cited by 11 publications

(3 citation statements)

References 10 publications

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“…It has been reported that the effi cacy of 4 μg/kg tetragastrin is almost equal to that of 6 μg/kg pentagastrin in stimulating gastric acid secretion. 40,41 The manufacture of tetragastrin on a commercial basis as a stimulating agent for gastric acid testing was discontinued in Japan in 1998. Hence, since this agent became unavailable, we have used pentagastrin in our laboratory.…”

Section: Congo Red Chromoendoscopymentioning

confidence: 99%

Sustained epithelial proliferation in a functionally irreversible fundic mucosa after Helicobacter pylori eradication

et al. 2009

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Functionally irreversible (non-acid-secreting) gastric mucosa after eradication was associated with extensive intestinal metaplasia and sustained hyperproliferation, suggesting that such mucosa still possesses malignant potential. Congo red chromoendoscopy may be useful for estimating the risk of subsequent development of gastric cancer following successful H. pylori eradication by determining the distribution of functionally irreversible mucosa.

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Section: Congo Red Chromoendoscopymentioning

confidence: 99%

Sustained epithelial proliferation in a functionally irreversible fundic mucosa after Helicobacter pylori eradication

et al. 2009

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“…AOC-TP was also found to be useful for analysis of gastric conditions following a multicenter pilot study included 401 patients (10). As indicated in this study, differences in metabolism of these peptides exist and speculation of the metabolism of endogenous gastrin from results obtained using gastrin-like tetra and pentapeptide amides appears complicated.…”

Section: Discussionmentioning

confidence: 74%

Absorption, Distribution and Excretion of Gastrin and Gastrin-Like Tetrapeptide

Ishíi¹,

Nishizawa²,

Mizuguchi³

et al. 1972

Jpn.J.Pharmacol

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“…In 9 out of 10 gastric ulcer patients and 10 out of 16 duodenal ulcer patients, gastric analysis was carried out. AOC-tetragastrin in a dose of 4 ug per kg body weight was used for maximum stimulation of acid secretion (Yamagata et al 1970). The gastric acid concentration was determined by automatic titration to pH 7.0, and basal acid output (BAO) during 1 hr and maximal acid output (MAO) during 1 hr were calculated.…”

Section: Methodsmentioning

confidence: 99%

Mucosal secretin of the duodenum in peptic ulcer disease.

Koizumi

Ishimori

Nakanome

et al. 1981

Tohoku J. Exp. Med.

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Mucosal secretin content of the duodenum was measured using bioptic specimen in healthy controls and patients of peptic ulcer. Immunoreactive secretin in the duodenal mucosa was found greater in healthy controls (7.73±2.71 ng/mg dry wt., mean±s.D.) than in gastric ulcer patients (5.76±3.51 ng/mg dry wt.) and duodenal ulcer patients (5.54±2.48 ng/mg dry wt.), but the difference was not significant. There was no significant relationship between mucosal secretin and acid output in these patients.-mucosal secretin; gastric ulcer; duodenal ulcer; acid secretion It has been pointed out repeatedly that gastric acid secretion and gastric emptying time in gastric ulcer patients are different from those in duodenal ulcer patients. To explain acid hypersecretion found in duodenal ulcer, an abnormality in secretin metabolism was reported often. But most of the works done to date were based on the observation of pancreatic exocrine secretion (Dreiling 1953;Banks et al. 1967;Wormsley and Mahoney 1967; Peterson 1970;Wormsley 1970) or blood secretin level (Bloom and Ward 1975;Isenberg et al. 1977). There are few studies to attack this problem from mucosal secretin level. In the present study, the mucosal secretin content was measured by radioimmunoassay technique and compared with gastric secretion. MATERIALS AND METHODSFour healthy subjects (3 men and 1 woman, mean age of 48) who were examined for screening of gastrointestinal malignancy, 10 gastric ulcer patients (8 men and 2 women, mean age of 44) and 16 duodenal ulcer patients (13 men and 3 women, mean age of 32) were included in this study. All subjects including 4 healthy controls had been informed beforehand of the purpose and outline of the study and their consent had been obtained. After an overnight fast, 6 to 8 specimens of duodenal mucosa were obtained from the anterior

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Gastric Secretion Stimulated by Gastrin-like AOC-tetrapeptide

Cited by 11 publications

References 10 publications

Sustained epithelial proliferation in a functionally irreversible fundic mucosa after Helicobacter pylori eradication

Sustained epithelial proliferation in a functionally irreversible fundic mucosa after Helicobacter pylori eradication

Absorption, Distribution and Excretion of Gastrin and Gastrin-Like Tetrapeptide

Mucosal secretin of the duodenum in peptic ulcer disease.

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